Results 51 to 60 of about 18,915,503 (310)

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

open access: yesNature Communications, 2023
Glial cells have been proposed as a source of neural progenitors, but the mechanisms underpinning the neurogenic potential of adult glia are not known.
Anna Laddach   +14 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Drugs and the autonomic nervous system [PDF]

open access: yes, 2012
The nervous systems can initially be divided up into the central and peripheral nervous systems. The central nervous system is the brain and spinal cord and drugs that modify the central nervous system are considered as a subject in systematic ...
Doggrell, Sheila
core  

Ageing and the autonomic nervous system

open access: yes, 2003
The vertebrate nervous system is divided into central (CNS) and peripheral (PNS) components. In turn, the PNS is divided into the autonomic (ANS) and enteric (ENS) nervous systems.
Tse, Gary   +4 more
core   +1 more source

The WW domain presents a promising target for the development of PCIF1 agonists in the treatment of glioma

open access: yesnpj Precision Oncology
PCIF1 is currently the sole m6Am methyltransferase in mammalian mRNA, but it was initially named for the interaction between its WW domain and RNA polymerase II.
Jiale Yin   +9 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Cognitive impairments in patients with prior ischemic stroke

open access: yesНеврология, нейропсихиатрия, психосоматика, 2014
The authors give the data available in the literature on and the results of their studies of the epidemiology, risk factors, pathogenesis, diagnosis, and treatment of poststroke cognitive impairment (PSCI).
V. A. Parfenov   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT)

open access: yes, 2013
OBJECTIVE: This study investigated epigenetic modifications in human central nervous system atypical teratoid rhabdoid tumors (AT/RTs), in response to inhibition of insulin-like growth factor receptor 1 (IGF-1R).
김동석, 심규원
core   +1 more source

2021 Editor’s Choice Articles in the Section “Cells of the Nervous System”

open access: yes, 2022
Referenced below are the top 10 cited papers in 2021 from the Section “Cells of the Nervous System”, published in Cells (ISSN: 2073-4409) [...
Naweed I. Syed, Syed, Naweed I.
core   +1 more source

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