Results 61 to 70 of about 1,882,276 (313)

Spinal cord issues in adult patients with MPS: transition of care survey

, 2018
12 páginasPurpose This study aims to raise awareness of the need for research and appropriate guidelines for managing spinal cord issues in adult patients with mucopolysaccharidosis (MPS) and transition of these patients from pediatric to adult care ...
White, Klane K., Martha Solano-Villareal, Harmatz, Paul R., Solano Villareal, Martha, Christina Lampe, Kemel A. Ghotme, Alvarado Gómez, Fernando, Giugliani, Roberto, Roberto Giugliani, Fernando Alvarado-Gomez, Lampe, Christina, Paul R. Harmatz, Klane K. White, Ghotme, Kemel A.   +13 more
core   +1 more source

Acute disseminated encephalomyelitis with delayed onset and feasibility of the Miethke shunt and sensor reservoir system : a case report

, 2021
Acute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating central nervous system disorder with predilection for early childhood.
Grabowska, A, Petursdottir, Dyrleif, Rostami, E,, Ehrstedt, Christoffer, Grabowska, Anna, Liminga, Gunnar, Ehrstedt, Christoffer,, Petursdottir, D, Grabowska, Anna,, Rostami, Elham,, Ehrstedt, C, Cesarini, KG, Cesarini, Kristina G,, Liminga, Gunnar,, Rostami, Elham, Cesarini, Kristina G, Petursdottir, Dyrleif,, Liminga, G   +17 more
core   +1 more source

Effects of the mGlu2/3 receptor agonist LY379268 on two models of disturbed auditory evoked brain oscillations in mice

Translational Psychiatry, 2023
Cognitive impairment is a core feature of schizophrenia and is poorly addressed by currently available medication. This is partly because the underlying circuits are insufficiently understood, and available animal models for brain dysfunction do not ...
Oana-Daniela Dormann, Niklas Schuelert, Holger Rosenbrock   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Epigenetic modification after inhibition of IGF-1R signaling in human central nervous system atypical teratoid rhabdoid tumor (AT/RT)

, 2013
OBJECTIVE: This study investigated epigenetic modifications in human central nervous system atypical teratoid rhabdoid tumors (AT/RTs), in response to inhibition of insulin-like growth factor receptor 1 (IGF-1R).
김동석, 심규원
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

SWAP-70 promotes glioblastoma cellular migration and invasion by regulating the expression of CD44s

Cancer Cell International, 2019
Background Switch-associated protein 70 (SWAP-70) is a guanine nucleotide exchange factor that is involved in cytoskeletal rearrangement and regulation of migration and invasion of malignant tumors.
Lin Shi, Huize Liu, Yifeng Wang, Yulong Chong, Jie Wang, Guanzheng Liu, Xu Zhang, Xiangyu Chen, Huan Li, Mingshan Niu, Jun Liang, Rutong Yu, Xuejiao Liu   +12 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Factors affecting diagnosis of primary pediatric central nervous system neoplasias in a developing country

, 2020
Understand the variables that could interfere with diagnosis and prompt treatment in CNS childhood cancer in Brazil, a developing country with continental dimensions.MethodsFrom 2005 to 2010, we retrospectively evaluated factors, which could represent a ...
Aguiar, Simone dos Santos, Morcillo, Andre Moreno, Tedeschi, Helder, Ghizoni, Enrico, Gilli, Isadora Olenscki, Joaquim, Andrei Fernandes   +5 more
core   +1 more source

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAF V600E /TERT promoter double-mutated glioma

Acta Neuropathologica Communications, 2019
The BRAF gene and the TERT promoter are among the most frequently altered genomic loci in low-grade (LGG) and high-grade-glioma (HGG), respectively.
Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, Sushilla van Schoonhoven, Hannah M. Schmidt, Lisa Mayr, Christine Pirker, Katharina Neumayer, Carina Dinhof, Lucia Kastler, Amedeo A. Azizi, Christian Dorfer, Thomas Czech, Christine Haberler, Andreas Peyrl, Rajiv Kumar, Irene Slavc, Sabine Spiegl-Kreinecker, Johannes Gojo, Walter Berger   +19 more
doaj   +1 more source