Results 61 to 70 of about 18,915,503 (310)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Epidemiological Analysis of Central Nervous System Teratomas in SEER Database
, 2020 Objectives:Teratomas are nongernimmatomatous germ cell tumors of the central nervous system. The aim of this study was to investigate the epidemiological features of central nervous system teratomas.Materials and Methods:Central nervous system teratomas ...
Ercan Bal +4 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Spinal cord issues in adult patients with MPS: transition of care survey
, 2018 12 páginasPurpose This study aims to raise awareness of the need for research and appropriate guidelines for managing spinal cord issues in adult patients with mucopolysaccharidosis (MPS) and transition of these patients from pediatric to adult care ...
White, Klane K. +13 more
core +1 more source
SWAP-70 promotes glioblastoma cellular migration and invasion by regulating the expression of CD44s
Cancer Cell International, 2019 Background Switch-associated protein 70 (SWAP-70) is a guanine nucleotide exchange factor that is involved in cytoskeletal rearrangement and regulation of migration and invasion of malignant tumors.
Lin Shi +12 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2020 Purpose The aim of this study was to evaluate the lengthening or replacement of the peritoneal catheter in a ventriculoperitoneal shunt by using a simple guidewire-assisted technique.
Munar Bauzá, Francisca +5 more
core +1 more source
The feasibility of using circular training method for skiers-junior with regard typological properties nervous system [PDF]
, 2014 Purpose: to determine the effect of a circular method of training on physical performance junior skiers depending on the strength of the nervous system. Material : the study involved 22 skiers (age 11 years).
Omelyanenko V. I., V. I. Omelyanenko
core +1 more source
Acta Neuropathologica Communications, 2019 The BRAF gene and the TERT promoter are among the most frequently altered genomic loci in low-grade (LGG) and high-grade-glioma (HGG), respectively.
Lisa Gabler +19 more
doaj +1 more source