Results 71 to 80 of about 25,652,950 (386)

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

Engineered oncolytic virus coated with anti-PD-1 and alendronate for ameliorating intratumoral T cell hypofunction

Experimental Hematology & Oncology
Background Glioblastoma is a highly aggressive and devastating primary brain tumor that is resistant to conventional therapies. Oncolytic viruses represent a promising therapeutic approach for glioblastoma by selectively lysing tumor cells and eliciting ...
Yufu Zhu, Xuefeng Zhang, Jiaqi Jin, Xiaoqian Wang, Yang Liu, Jian Gao, Diancheng Hang, Lin Fang, Hengzhu Zhang, Hongmei Liu   +9 more
doaj   +1 more source

COVID-19 and the nervous system

Journal of Neurovirology, 2020
A pandemic due to novel coronavirus arose in mid-December 2019 in Wuhan, China, and in 3 months’ time swept the world. The disease has been referred to as COVID-19, and the causative agent has been labelled SARS-CoV-2 due to its genetic similarities to ...
J. Berger
semanticscholar   +1 more source

Intraoperative Neurophysiological Monitoring for Endoscopic Endonasal Approaches to the Skull Base: A Technical Guide. [PDF]

, 2016
Intraoperative neurophysiological monitoring during endoscopic, endonasal approaches to the skull base is both feasible and safe. Numerous reports have recently emerged from the literature evaluating the efficacy of different neuromonitoring tests during
Doan, Adam T., Evans, James J., Kenning, Tyler J., Lober, Robert M., Matsumoto, Craig I., Singh, Harminder, Vogel, Richard W.   +6 more
core   +3 more sources

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

The Neurophysiology of Caffeine as a Central Nervous System Stimulant and the Resultant Effects on Cognitive Function [PDF]

, 2021
Brian Fiani, Lawrence Zhu, Brian Musch, Sean Briceno, Ross Andel, Nasreen Sadeq, Ali Z Ansari   +6 more
openalex   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

The WW domain presents a promising target for the development of PCIF1 agonists in the treatment of glioma

npj Precision Oncology
PCIF1 is currently the sole m6Am methyltransferase in mammalian mRNA, but it was initially named for the interaction between its WW domain and RNA polymerase II.
Jiale Yin, Gai Liu, Yu Zhou, Junbo Zhou, Mengzhe Guo, Zhiyuan Hu, Preethi Priyanka Musunuru, Rutong Yu, Qingming Meng, Shangfeng Gao   +9 more
doaj   +1 more source

Cognitive impairments in patients with prior ischemic stroke

Неврология, нейропсихиатрия, психосоматика, 2014
The authors give the data available in the literature on and the results of their studies of the epidemiology, risk factors, pathogenesis, diagnosis, and treatment of poststroke cognitive impairment (PSCI).
V. A. Parfenov, M. A. Cherdak, N. V. Vakhnina, S. V. Verbitskaya, L. Yu. Nikitina   +4 more
doaj   +1 more source

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. [PDF]

, 2020
The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines ...
Abumaria, Nashat, Ambrozkiewicz, Mateusz C, Beier, Kevin T, Benseler, Fritz, Brose, Nils, Burgess, Harold A, Cepko, Constance L, Chen, Cui, Cloutier, Jean-François, Craig, Ann Marie, Dumontier, Emilie, Eroglu, Cagla, Falkner, Susanne, Furlanis, Elisabetta, Goebbels, Sandra, Gomez, Andrea M, Hoshina, Naosuke, Huang, Wei-Hsiang, Hutchison, Mary Anne, Itoh-Maruoka, Yu, Kaeser, Pascal S, Kawabe, Hiroshi, Kay, Jeremy N, Lavery, Laura A, Li, Wei, Lu, Wei, Luo, Lin, Luo, Liqun, Mandai, Kenji, Maruo, Tomohiko, McBain, Chris J, Motohashi, Junko, Nave, Klaus-Armin, Pai, Emily Ling-Lin, Pelkey, Kenneth A, Pereira, Ariane, Philips, Thomas, Prado, Marco AM, Prado, Vania F, Rothstein, Jeffrey, Rubenstein, John LR, Saher, Gesine, Sakimura, Kenji, Sanes, Joshua R, Scheiffele, Peter, Sinclair, Jennifer L, Stogsdill, Jeff A, Takai, Yoshimi, Traunmüller, Lisa, Umemori, Hisashi, Verhage, Matthijs, Wang, Jiexin, Wortel, Joke, You, Wenjia, Yuzaki, Michisuke, Zoghbi, Huda Yahya   +55 more
core   +2 more sources