Results 41 to 50 of about 2,389,964 (125)

The functional diversity of Aurora kinases: a comprehensive review

Cell Division, 2018
Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellular localization.
Estelle Willems, Matthias Dedobbeleer, Marina Digregorio, Arnaud Lombard, Paul Noel Lumapat, Bernard Rogister   +5 more
doaj   +1 more source

The third-generation EGFR inhibitor AZD9291 overcomes primary resistance by continuously blocking ERK signaling in glioblastoma

Journal of Experimental & Clinical Cancer Research, 2019
Background Glioblastoma (GBM) is a fatal brain tumor, lacking effective treatment. Epidermal growth factor receptor (EGFR) is recognized as an attractive target for GBM treatment. However, GBMs have very poor responses to the first- and second-generation
Xuejiao Liu, Xiangyu Chen, Lin Shi, Qianqian Shan, Qiyu Cao, Chenglong Yue, Huan Li, Shengsheng Li, Jie Wang, Shangfeng Gao, Mingshan Niu, Rutong Yu   +11 more
doaj   +1 more source

Effects of the mGlu2/3 receptor agonist LY379268 on two models of disturbed auditory evoked brain oscillations in mice

Translational Psychiatry, 2023
Cognitive impairment is a core feature of schizophrenia and is poorly addressed by currently available medication. This is partly because the underlying circuits are insufficiently understood, and available animal models for brain dysfunction do not ...
Oana-Daniela Dormann, Niklas Schuelert, Holger Rosenbrock   +2 more
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Comprehensive profiling of stem-like features in pediatric glioma cell cultures and their relation to the subventricular zone

Acta Neuropathologica Communications, 2023
Pediatric high-grade gliomas (pHGG) are brain tumors occurring in children and adolescents associated with a dismal prognosis despite existing treatments. Therapeutic failure in both adult and pHGG has been partially imputed to glioma stem cells (GSC), a
Marc-Antoine Da-Veiga, Natacha Coppieters, Arnaud Lombard, Bernard Rogister, Virginie Neirinckx, Caroline Piette   +5 more
doaj   +1 more source

Novel Advancements in Three-Dimensional Neural Tissue Engineering and Regenerative Medicine [PDF]

Neural Regen. Res. 2015;10(3):352-4, 2015
Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of people each year, and yet there are currently no therapies or interventions that can repair the structure of neural ...
arxiv   +1 more source

Hereditary neuropathy with liability to pressure palsies: a case report

Неврология, нейропсихиатрия, психосоматика, 2021
Hereditary neuropathy with liability to pressure palsies (HNPP) is a rare hereditary disorder characterized by recurrent episodes of nerve compression. The first attack usually occurs in the second or third decade of life.
A. K. Polynnikova, O. E. Zinovyeva, O. A. Solokha, E. V. Misyuryaeva   +3 more
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Molecular dynamics studies on the NMR structures of rabbit prion protein wild-type and mutants: surface electrostatic charge distributions [PDF]

J Biomol Struct Dyn 33(6) 1326-35 (2015), 2014
Prion is a misfolded protein found in mammals that causes infectious diseases of the nervous system in humans and animals. Prion diseases are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species such as sheep and goats, cattle, deer, elk and humans etc.
arxiv   +1 more source

RETRACTED ARTICLE: GRP78 determines glioblastoma sensitivity to UBA1 inhibition-induced UPR signaling and cell death

Cell Death and Disease, 2021
Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor for which new therapeutic approaches are urgently required. Unfolded protein response (UPR) plays an important role in the progression of GBM and is a promising target for developing ...
Guanzheng Liu, Jiefeng Yu, Runqiu Wu, Lin Shi, Xu Zhang, Wanhong Zhang, Xiaomin Zhong, Yifeng Wang, Huan Li, Yang Shen, Changyong Wu, Rutong Yu, Mingshan Niu, Xuejiao Liu   +13 more
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UBA1 inhibition contributes radiosensitization of glioblastoma cells via blocking DNA damage repair

Frontiers in Pharmacology, 2023
Glioblastoma multiforme (GBM) is a brain tumor with high mortality and recurrence rate. Radiotherapy and chemotherapy after surgery are the main treatment options available for GBM. However, patients with glioblastoma have a grave prognosis.
Changyong Wu, Changyong Wu, Yang Shen, Yang Shen, Lin Shi, Lin Shi, Lin Shi, Junhao Zhang, Tongxuan Guo, Lingni Zhou, Wanzhou Wang, Xu Zhang, Xu Zhang, Rutong Yu, Rutong Yu, Xuejiao Liu, Xuejiao Liu   +16 more
doaj   +1 more source

SWAP-70 promotes glioblastoma cellular migration and invasion by regulating the expression of CD44s

Cancer Cell International, 2019
Background Switch-associated protein 70 (SWAP-70) is a guanine nucleotide exchange factor that is involved in cytoskeletal rearrangement and regulation of migration and invasion of malignant tumors.
Lin Shi, Huize Liu, Yifeng Wang, Yulong Chong, Jie Wang, Guanzheng Liu, Xu Zhang, Xiangyu Chen, Huan Li, Mingshan Niu, Jun Liang, Rutong Yu, Xuejiao Liu   +12 more
doaj   +1 more source