Results 41 to 50 of about 2,814,068 (394)
Differential in vitro infection of neural cells by astroviruses [PDF]
, 2019 Encephalitis remains a diagnostic conundrum in humans as over 50% of cases are managed without the identification of an etiology. Astroviruses have been detected from the central nervous system of mammals in association with disease, suggesting that this
Janowski, Andrew B +2 more
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Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]
, 2020 In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong +15 more
core +1 more source
Role of the Cholinergic Anti-Inflammatory Reflex in Central Nervous System Diseases
International Journal of Molecular Sciences, 2021 In several central nervous system diseases, it has been reported that inflammation may be related to the etiologic process, therefore, therapeutic strategies are being implemented to control inflammation.
I. Ramos-Martínez +4 more
semanticscholar +1 more source
The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]
, 2017 Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela +3 more
core +2 more sources
Medicinal research reviews (Print), 2020 Neurological disorders significantly outnumber diseases in other therapeutic areas. However, developing drugs for central nervous system (CNS) disorders remains the most challenging area in drug discovery, accompanied with the long timelines and high ...
Sezen Vatansever +6 more
semanticscholar +1 more source
The Role of Mfsd2a in Nervous System Diseases
Frontiers in Neuroscience, 2021 Major facilitator superfamily (MFS) is the maximum and most diversified membrane transporter, acting as uniporters, symporters and antiporters. MFS is considered to have a good development potential in the transport of drugs for the treatment of brain ...
B. Huang, Xihong Li
semanticscholar +1 more source
Design and construction of a distributed sensor NET for biotelemetric monitoring of brain energetic metabolism using microsensors and biosensors [PDF]
, 2010 Neurochemical pathways involved in brain physiology or disease pathogenesis are mostly unknown either in physiological conditions or in neurodegenerative diseases.
Bazzu, Gianfranco +5 more
core +2 more sources
Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression
Journal of Pharmacological Sciences, 2015 Plumbagin is a natural compound that is isolated from the root of the medicinal plant Plumbago zeylanica L. Based on a previous in vitro study performed by our group, which demonstrated the effectiveness of plumbagin against glioma cells, we further ...
Mingshan Niu +9 more
doaj +1 more source
Cancer Cell International, 2020 Background Activation of nuclear factor-kappa B (NF-κΒ) through DNA damage is one of the causes of tumor cell resistance to radiotherapy. Chromosome region 1 (CRM1) regulates tumor cell proliferation, drug resistance, and radiation resistance by ...
Xuejiao Liu +12 more
doaj +1 more source
Scientific Reports, 2021 Molluscs are one of the sources of biologically active substances, which are now intensively studied, especially for their anti-cancer properties. Malignant melanoma originates from melanocytes, develops very quickly and is associated with poor prognosis.
Leśków Anna +3 more
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