Results 41 to 50 of about 2,663,952 (341)
The functional diversity of Aurora kinases: a comprehensive review
Cell Division, 2018 Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellular localization.
Estelle Willems +5 more
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Journal of Experimental & Clinical Cancer Research, 2019 Background Glioblastoma (GBM) is a fatal brain tumor, lacking effective treatment. Epidermal growth factor receptor (EGFR) is recognized as an attractive target for GBM treatment. However, GBMs have very poor responses to the first- and second-generation
Xuejiao Liu +11 more
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Translational Psychiatry, 2023 Cognitive impairment is a core feature of schizophrenia and is poorly addressed by currently available medication. This is partly because the underlying circuits are insufficiently understood, and available animal models for brain dysfunction do not ...
Oana-Daniela Dormann +2 more
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Advances in intranasal application of stem cells in the treatment of central nervous system diseases
Stem cell research & therapeutics, 2021 Stem cells are characterized by their self-renewal and multipotency and have great potential in the therapy of various disorders. However, the blood–brain barrier (BBB) limits the application of stem cells in the therapy of neurological disorders ...
Yu-ting Zhang +5 more
semanticscholar +1 more source
Role of CD36 in central nervous system diseases. [PDF]
Neural Regen Res, 2023 CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic diseases.
Feng M +7 more
europepmc +2 more sources
Acta Neuropathologica Communications, 2023 Pediatric high-grade gliomas (pHGG) are brain tumors occurring in children and adolescents associated with a dismal prognosis despite existing treatments. Therapeutic failure in both adult and pHGG has been partially imputed to glioma stem cells (GSC), a
Marc-Antoine Da-Veiga +5 more
doaj +1 more source
Infectious Disease Clinics of North America, 1998 Lyme disease, the multi-system infection caused by the tick-borne spirochaete Borrelia burgdorferi, can involve the nervous system, most commonly causing, alone or in combination, lymphocytic meningitis or abnormalities of cranial or peripheral nerves, the latter most typically presenting as a painful radicular syndrome.
openaire +9 more sources
Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation
International Journal of Molecular Sciences, 2021 Hyperhomocysteinemia (HHcy) is remarkably common among the aging population. The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer’s disease (AD) and eye diseases, and age-related macular degeneration (AMD) and ...
A. Tawfik +3 more
semanticscholar +1 more source
Cell Death and Disease, 2021 Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor for which new therapeutic approaches are urgently required. Unfolded protein response (UPR) plays an important role in the progression of GBM and is a promising target for developing ...
Guanzheng Liu +13 more
doaj +1 more source
Hereditary neuropathy with liability to pressure palsies: a case report
Неврология, нейропсихиатрия, психосоматика, 2021 Hereditary neuropathy with liability to pressure palsies (HNPP) is a rare hereditary disorder characterized by recurrent episodes of nerve compression. The first attack usually occurs in the second or third decade of life.
A. K. Polynnikova +3 more
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