Results 41 to 50 of about 1,058,449 (296)

Engineered oncolytic virus coated with anti-PD-1 and alendronate for ameliorating intratumoral T cell hypofunction

Experimental Hematology & Oncology
Background Glioblastoma is a highly aggressive and devastating primary brain tumor that is resistant to conventional therapies. Oncolytic viruses represent a promising therapeutic approach for glioblastoma by selectively lysing tumor cells and eliciting ...
Yufu Zhu, Xuefeng Zhang, Jiaqi Jin, Xiaoqian Wang, Yang Liu, Jian Gao, Diancheng Hang, Lin Fang, Hengzhu Zhang, Hongmei Liu   +9 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The WW domain presents a promising target for the development of PCIF1 agonists in the treatment of glioma

npj Precision Oncology
PCIF1 is currently the sole m6Am methyltransferase in mammalian mRNA, but it was initially named for the interaction between its WW domain and RNA polymerase II.
Jiale Yin, Gai Liu, Yu Zhou, Junbo Zhou, Mengzhe Guo, Zhiyuan Hu, Preethi Priyanka Musunuru, Rutong Yu, Qingming Meng, Shangfeng Gao   +9 more
doaj   +1 more source

Diagnosis of Alzheimer's disease by using biological markers in posterior cortical atrophy

Неврология, нейропсихиатрия, психосоматика
The use of biological markers for Alzheimer's disease (AD) allows diagnosis at the stage of moderate cognitive impairment and atypical course of the disease.
D. A. Grishina, N. A. Khayalieva, V. V. Grinyuk, A. Yu. Tyurina   +3 more
doaj   +1 more source

Visualizing enteric nervous system activity through dye-free dynamic full-field optical coherence tomography

Communications Biology, 2023
Full-field optical coherence tomography (FFOCT) can be used for the visualization of the myenteric plexus network and individual myenteric ganglia cells in situ, showing that FFOCT is a suitable method to image enteric nervous system activity.
Tony Durand, Perrine Paul-Gilloteaux, Michalina Gora, Lara Laboudie, Emmanuel Coron, Isabelle Neveu, Michel Neunlist, Philippe Naveilhan   +7 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Drug therapy for chronic musculoskeletal pain syndromes: the concept of adjuvant analgesics and the prospect of its implementation

Неврология, нейропсихиатрия, психосоматика, 2020
Treatment for pain syndromes is one of the most relevant areas of modern medicine, which is of high social, economic and, individual importance. One of the most difficult questions is therapy for chronic pain (CP).
S. A. Zhivolupov, I. V. Litvinenko, I. N. Samartsev, N. A. Rashidov, A. Yu. Kravchuk, A. N. Barinov   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Concentration of immunoglobulin free light chains in cerebrospinal fluid in the diagnosis of multiple sclerosis

Неврология, нейропсихиатрия, психосоматика
Objective: to determine the sensitivity and specificity of method of determining the concentration of immunoglobulin free light chains (FLCs) in cerebrospinal fluid (CSF) in the diagnosis and differential diagnosis of multiple sclerosis (MS).Material and
Sh. R. Nabiev, S. A. Dzhukkaeva, M. Sh. Asvedov, D. E. Prokhorov, E. V. Popova, V. V. Grinyuk, P. R. Magomadova, A. R. Apevalova, O. N. Voskresenskaya   +8 more
doaj   +1 more source