Results 51 to 60 of about 2,231 (116)

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Cell Mechanics in Cancer: Integrating Mechanotransduction Pathways Within the Tumor Microenvironment

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Single‐cell mechanical properties such as stiffness, elasticity, and viscosity, are crucial in governing biological processes like migration, proliferation, and differentiation. In cancer, the mechanical properties of cells undergo significant alterations, which contribute to tumor growth, metastasis, and resistance to therapy.
Merve Sevgi, Yağmur Işık, Caner Karaca, Esmahan Çağlar, Hasan Berkay Abdioğlu, Ferican Zendel, Yasemin Başbınar, Hüseyin Üvet   +7 more
wiley   +1 more source

Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications

Exploration, Volume 6, Issue 2, April 2026.
Micro patterns are characterized as a coating of specific adhesion matrices on substrates to support cell growth. An overview of micropattern technology to regulate single cell morphology and fates, further focusing on the micro pattern‐based 3D cell culture platform used in the non‐tumor and tumor researches.
Xinglong Zhu, Yi Li, Hulin Long, Yijia Wu, Ningwei Sun, Shun Li, Yiyao Liu, Huiqi Xie, Ji Bao   +8 more
wiley   +1 more source

The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component

BMC Cell Biology, 2011
Background DYT1 dystonia is an autosomal dominant neurological condition caused by a mutation that removes a single glutamic acid residue (ΔE) from the torsinA (torA) AAA+ protein.
Jeong Danielle Y, Kumar Dhivya, Jungwirth Michael T, Goodchild Rose E   +3 more
doaj   +1 more source

A Genetic Landscape of Euploid Miscarriages From Couples With Recurrent Pregnancy Loss Through Whole Exome Sequencing

Molecular Genetics &Genomic Medicine, Volume 14, Issue 4, April 2026.
Whole exome sequencing analysis on 55 couples and miscarriages from their current pregnancies reveals a significant heterogeneity and complexity in exomic variants contributing to RPL. ABSTRACT Background This study aimed to identify candidate genes for recurrent pregnancy loss (RPL).
Fanjuan Kong, Zhaochu Yin, Haiyan Zhou, Zhiyu Liu, Wanqin Xie   +4 more
wiley   +1 more source

Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running.

PLoS ONE
The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex serves to connect the nuclear envelope and the cytoskeleton, influencing cellular processes such as nuclear arrangement, architecture, and mechanotransduction.
Scott Birks, Sean Howard, Christian S Wright, Caroline O'Rourke, Elicza A Day, Alexander J Lamb, James R Walsdorf, Anthony Lau, William R Thompson, Gunes Uzer   +9 more
doaj   +1 more source

Genomic Correlates of Disease Recovery in Natural Populations of the Sierra Nevada Yellow‐Legged Frog (Rana sierrae)

Molecular Ecology, Volume 35, Issue 8, April 2026.
ABSTRACT In our rapidly changing world, evolution is likely to play an important role in facilitating the resilience of wildlife populations. The Sierra Nevada yellow‐legged frog (Rana sierrae) provides a rare example of recovery following severe declines caused by the amphibian chytrid fungus (Batrachochytrium dendrobatidis).
Allison Q. Byrne, Andrew P. Rothstein, Roland A. Knapp, Erica Bree Rosenblum   +3 more
wiley   +1 more source

The Critical Role of Transcription Factor RUNX2 in Bone Mechanobiology

Cells
Mechanobiology plays a pivotal role in skeletal development and bone remodeling. Mechanical signals such as matrix stiffness, fluid shear stress, and hydrostatic pressure activate the Runt-related transcription factor 2 (RUNX2) bone-specific ...
Maria A. Katsianou, Antonios N. Gargalionis, Kostas A. Papavassiliou, Angeliki Margoni, Athanasios G. Papavassiliou, Efthimia K. Basdra   +5 more
doaj   +1 more source

SYNE1-related spastic-ataxia: A nuclear envelopathy beyond French Canadians

Annals of Movement Disorders
Spectrin Repeat Containing Nuclear Envelope Protein 1 (SYNE1), one of the largest genes in the human genome, encodes the scaffold protein nesprin-1, a critical component of the linker of nucleoskeleton and cytoskeleton complex.
Jacky Ganguly, Sayoni Roychowdhury, Divyani Garg, Neha Pandita, Debayan Dutta, Soumava Mukherjee, Purba Basu, Hrishikesh Kumar   +7 more
doaj   +1 more source

Tail-anchored membrane protein SLMAP3 is essential for targeting centrosomal proteins to the nuclear envelope in skeletal myogenesis

Open Biology
The positioning and communication between the nucleus and centrosomes are essential in cell division, differentiation and tissue formation. During skeletal myogenesis, the nuclei become evenly spaced with the switch of the microtubule-organizing centre ...
Ana Paula Dias, Taha Rehmani, Maysoon Salih, Balwant Tuana   +3 more
doaj   +1 more source