Results 1 to 10 of about 41,897 (208)

Nestin promotes imatinib resistance in gastrointestinal stromal tumors by enhancing PINK1-dependent mitophagy [PDF]

Molecular Medicine
Background Gastrointestinal stromal tumors (GIST) frequently develop secondary resistance to imatinib, which represents a major obstacle to achieving durable clinical benefit. However, the molecular mechanisms underlying acquired resistance remain poorly
Yuehan Yin, Juzheng Peng, Zhijian Huang, Dongsheng Li, Xiangyu Li, Zhengchao Hong, Yuqing Lin, Yulong He, Jiancheng Wang   +8 more
doaj   +2 more sources

Distribution, contribution and regulation of nestin+ cells

Journal of Advanced Research
Background: Nestin is an intermediate filament first reported in neuroepithelial stem cells. Nestin expression could be found in a variety of tissues throughout all systems of the body, especially during tissue development and tissue regeneration ...
Zi Yin
exaly   +3 more sources

Nestin Is Essential for Zebrafish Brain and Eye Development through Control of Progenitor Cell Apoptosis [PDF]

PLoS ONE, 2010
BACKGROUND: Nestin is expressed in neural progenitor cells (NPC) of developing brain. Despite its wide use as an NPC marker, the function of nestin in embryo development is unclear.
Chiou-Hwa Yuh, Kenneth Wu
exaly   +2 more sources

Re-expression of the intermediate filament nestin in reactive astrocytes

Neurobiology of Disease, 1995
The intermediate filament nestin is highly expressed in multipotential stem cells of the developing central nervous system (CNS). During neuro- and gliogenesis, nestin is replaced by cell type-specific intermediate filaments, e.g.
R D McKay, O Brüstle, R C Lin
exaly   +3 more sources

Nestin as a Prognostic Marker in ductal carcinoma of the breast [PDF]

Zagazig University Medical Journal, 2023
Breast cancer is a heterogeneous disease that not only varies greatly between different patients but also even within each individual tumor . Nestin, a type VI intermediate filament expressed mainly in neural progenitor cells.
abeer abdelbary, nehal selim, mona george, Mena Hesham   +3 more
doaj   +1 more source

Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial–mesenchymal transition in lung endothelial cells

Cell Communication and Signaling, 2023
Background Nestin, an intermediate filament protein, participates in various pathophysiological processes, including wound healing, angiogenesis, endothelial–mesenchymal transition (EndoMT), and fibrosis.
Wakako Daido, Taku Nakashima, Takeshi Masuda, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori   +10 more
doaj   +1 more source

Nestin Expression Affects Resistance to Chemotherapy and Clinical Outcome in Small Cell Lung Cancer

Frontiers in Oncology, 2020
Objectives: Small cell lung cancer (SCLC) is an aggressive and highly metastatic lung cancer subtype. Nestin is a member of the intermediate filament family and serves as a potential proliferative and multipotency marker in neural progenitor and stem ...
Kazuki Sone, Ken Maeno, Ayako Masaki, Eiji Kunii, Osamu Takakuwa, Yusuke Kagawa, Akira Takeuchi, Satoshi Fukuda, Takehiro Uemura, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Hirotsugu Ohkubo, Masaya Takemura, Yutaka Ito, Tetsuya Oguri, Hiroshi Inagaki, Akio Niimi   +16 more
doaj   +1 more source

Role of the stem cell-associated intermediate filament nestin in malignant proliferation of non-small cell lung cancer. [PDF]

PLoS ONE, 2014
BackgroundNestin is associated with neoplastic transformation, but the mechanisms by which nestin contributes to invasion and malignancy of lung cancer remain unknown.
Zhenguang Chen, Jiancheng Wang, Lie Cai, Beilong Zhong, Honghe Luo, Yuantao Hao, Weihua Yu, Binchao Wang, Chunhua Su, Yiyan Lei, Amos Ela Bella, Andy Peng Xiang, Tao Wang   +12 more
doaj   +1 more source

The intermediate filament protein nestin serves as a molecular hub for smooth muscle cytoskeletal signaling

Respiratory Research, 2023
Background The recruitment of the actin-regulatory proteins cortactin and profilin-1 (Pfn-1) to the membrane is important for the regulation of actin cytoskeletal reorganization and smooth muscle contraction.
Yinna Wang, Guoning Liao, Yidi Wu, Ruping Wang, Dale D. Tang   +4 more
doaj   +1 more source

Nestin Promotes Peritoneal Fibrosis by Protecting HIF1-α From Proteasomal Degradation

Frontiers in Physiology, 2020
BackgroundPeritoneal dialysis (PD) is a treatment for end stage renal disease patients, but it can also cause peritoneal fibrosis. Nestin is known as a neural stem cell marker and it has many functions.
Yangping Shentu, Huanchang Jiang, Xiaoyuan Liu, Hao Chen, Dicheng Yang, Jinqi Zhang, Chen Cheng, Yulin Zheng, Yang Zhang, Chaosheng Chen, Chenfei Zheng, Ying Zhou   +11 more
doaj   +1 more source