Results 11 to 20 of about 41,897 (208)

Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines [PDF]

BMC Cancer, 2008
Background Nestin was originally identified as a class VI intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian CNS during development.
Zambo Iva, Chlapek Petr, Loja Tomas, Hermanova Marketa, Veselska Renata, Vesely Karel, Zitterbart Karel, Sterba Jaroslav   +7 more
doaj   +2 more sources

Nestin expression in the cell lines derived from glioblastoma multiforme [PDF]

BMC Cancer, 2006
Background Nestin is a protein belonging to class VI of intermediate filaments that is produced in stem/progenitor cells in the mammalian CNS during development and is consecutively replaced by other intermediate filament proteins (neurofilaments, GFAP).
Loja Tomas, Neradil Jakub, Svachova Hana, Cejpek Pavel, Kuglik Petr, Veselska Renata, Relichova Jirina   +6 more
doaj   +3 more sources

A Melanoma Transplanted in Nude Mice Has Both Host- and Tumor-Derived Blood Vessel- and Nerve-Like Structures. [PDF]

Cancer Sci
Nestin‐driven green fluorescent protein (ND‐GFP) expressing peripheral blood vessels and nerves in the subcutaneous tissue of the ND‐GFP mice extended into the transplanted melanoma such that ND‐GFP was enhanced at the margin of the melanoma compared to the tumor‐free side.
Obara K, Sasaki A, Hamada Y, Kubota Y, Aoki Y, Masaki N, Bouvet M, Amoh Y, Hoffman RM.   +8 more
europepmc   +2 more sources

Niche-Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids. [PDF]

Adv Sci (Weinh)
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Chen Z, Jiang L, Wang X, Zhong L, Luo R, Su M, Chu L, Luo P.   +7 more
europepmc   +2 more sources

Functional validation of driver mutation-specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity. [PDF]

J Pathol
Abstract Uveal melanoma (UM) is a deadly ocular malignancy with well‐described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high‐risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers
van den Bosch Q, Verdijk RM, Fadlelseed H, van den Bosch T, Owens S, Kennedy S, Kilic E, Brosens E.   +7 more
europepmc   +2 more sources

Nestin-expressing cell types in the temporal lobe and hippocampus: morphology, differentiation and proliferative capacity [PDF]

, 2017
Nestin is expressed in immature neuroepithelial and progenitor cell types and transiently upregulated in proliferative neuroglial cells responding to acute brain injury, including following seizures.
Miserocchi, A., Anna Miserocchi, Cheryl Reeves, Thomas, J., Joan Liu, Reeves, C, Thompson, P., Thom, M., Reeves, C., Sanjay Sisodiya, Liu, J, Andrew McEvoy, Thom, M, Maria Thom, Jacques, TS, Sisodiya, S, McEvoy, A., Sisodiya, S., Pamela Thompson, Thomas Jacques, Thompson, P, McEvoy, A, Miserocchi, A, Liu, J.   +23 more
core   +1 more source

Evaluation of the Expression and Prognosis of Neural-Related Products Expressed by Cancer-Derived Mesenchymal Stem Cells With the Characteristics of Neural Stem Cells. [PDF]

Cancer Med
ABSTRACT Studies have demonstrated that the nervous system plays an important role in cancer progression. Nevertheless, the effect of mesenchymal stem cells (MSCs) on cancer has yielded conflicting results. In this study, we discovered that cancer‐derived MSCs (CA‐MSCs) not only exhibit the properties of neural stem cells (NSCs) but also express a ...
Yongjun L, Zhiwen P, Shangui F, Jinjie Z, Rongbiao Y, Zhongjian C, Wanyuan C, Haixing J, Dening M, Dan L, Cong L, Zhixuan F.   +11 more
europepmc   +2 more sources

An Increase in Mesenchymal Stem Cells Expressing Nestin in Bone-Marrow-Derived Primary Cells Stimulates Neurogenic Differentiation in Rat

Journal of Animal Reproduction and Biotechnology, 2017
Mesenchymal stem cells (MSCs) have been considered an alternative source of neuronal lineage cells, which are difficult to isolate from brain and expand in vitro.
Na Rae Han, Hyun Lee, Jung Im Yun, Choonghyo Kim, Jae Yeon Hwang, Kyu Hyun Park, Seung Tae Lee   +6 more
doaj   +1 more source

Nestin modulates glucocorticoid receptor function by cytoplasmic anchoring. [PDF]

PLoS ONE, 2009
Nestin is the characteristic intermediate filament (IF) protein of rapidly proliferating progenitor cells and regenerating tissue. Nestin copolymerizes with class III IF-proteins, mostly vimentin, into heteromeric filaments.
Rudolph Reimer, Heike Helmbold, Beata Szalay, Christian Hagel, Heinrich Hohenberg, Wolfgang Deppert, Wolfgang Bohn   +6 more
doaj   +1 more source

MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin [PDF]

, 2012
BackgroundThe emerging concept is that microRNAs (miRNAs) play a central role in controlling stem cell self-renewal and fate determination by regulating the expression of stem cell regulators.
Xiaoran Li(李晓然), Jianwu Dai, Jie Sun, Jie Sun(孙杰), Jianwu Dai*, Yi Cui(崔熠), Yi Cui, Jin Han, Zhifeng Xiao, Wenyong Ding, Yannan Zhao, Xiaoran Li, Yanhan Zhao, Bing Chen   +13 more
core   +1 more source