Results 91 to 100 of about 3,408,233 (340)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Managing the Balance Between Project Value and Net Present Value Using Reinforcement Learning
IEEE AccessProject managers make decisions weighing financial returns (net present value, NPV) and value creation expected by stakeholders. Often, plans maximizing NPV neglect stakeholder benefits while those focused strictly on value creation may reduce financial ...
Claudio Szwarcfiter, Yale T. Herer
doaj +1 more source
INVESTMENT APPRAISAL CRITERIA UNDERLYING INVESTMENT DECISIONS [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2011 Companies that want to grow their activity must decide on which investment projects to focus. Investment in financial terms, represents a use of capital that at the end of the investment wants to obtain a profitability. Following the investment, the
Căruntu Roxana Corina
doaj
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Valuation of Cryptocurrency Mining Operations
Ledger, 2018 Traditionally, the Net Present Value method has been used to compare diverging investment strategies. However, valuating crypto-projects with fiat-based currency is confusing due to extreme coin appreciation rates as compared to fiat interest rates. Here,
Jose Berengueres
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The Net Present Value in Dynamic Models of the Firm [PDF]
, 1989 The aim of this chapter is to introduce the net present value in dynamic models of the firm as a method to determine an optimal investment policy of the firm. In fact we show that it is optimal for the firm to grow at its maximum if the net present value of marginal investment is positive.
openaire +6 more sources
The value of tax shields depends only on the net increases of debt [PDF]
The value of tax shields depends only on the nature of the stochastic process of the net increases of debt. The value of tax shields in a world with no leverage cost is the tax rate times the current debt plus the present value of the net increases of ...
Fernandez, Pablo
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Monte Carlo on Net Present Value for Capital Investment in Malaysia
, 2016 Capital investment becomes crucial investment decision in uncertain economic environment need to be made. Two major pitfall of classical net present value are uncertainty and managerial flexibilities.
Siti Salihah Shaffie, S. Jaaman
semanticscholar +1 more source
Theoretical Analysis of Net Present Value
BCP Business & Management, 2022 This paper reviews researches on net present value done by researchers in the past 25 years to summarize the research results and put forward limitations. Although the investment decision guided by net present value possesses a long history and investors use it widely in the current financial market, the author believes that it still has the value of ...
openaire +1 more source