Results 61 to 70 of about 1,202,845 (261)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Closed-Loop Supply Chain Network with Green Supplier Selection and Disassembly of Products: A Bi-Objective Model [PDF]
International Journal of Research in Industrial Engineering, 2013 This paper aims to study the impact of product greenness and part reliability on reverse supply chain network through green supplier selection and disassembly of products.
S. Ghayebloo, M.J. Tarokh, M. Abedzadeh
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Software tools for a multilayer network design
Journal of Telecommunications and Information Technology, 2005 Today’s long haul and metro high-speed networks are mainly based on synchronous digital hierarchy (SDH) or its American equivalent synchronous optical network (SONET) and wavelength division multiplex (WDM).
Holger Holler, Stefan Voß
doaj +1 more source
Hierarchical Ring Network design
Theory of Computing Systems, 2003 A hierarchical ring network is obtained from a ring network by appending at most one subsidiary ring to each node of the ring and, recursively, to each node of each subsidiary ring. The depth d is the number of levels of the recursive appending of subsidiary rings.
Bermond, Jean-Claude +2 more
openaire +3 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
AerospaceThe corridor network serves as an effective solution for the airspace structure safety design of UAM. However, current studies rarely account for the ground risk posed by the corridor operation and typically consider a single design objective with ...
Zhiyuan Zhang +4 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source