Results 1 to 10 of about 7,615,095 (307)

Network pharmacology: curing causal mechanisms instead of treating symptoms. [PDF]

Trends in Pharmacological Sciences, 2021
For complex diseases, most drugs are highly ineffective, and the success rate of drug discovery is in constant decline. While low quality, reproducibility issues, and translational irrelevance of most basic and preclinical research have contributed to ...
Cristian Nogales, Zeinab M. Mamdouh, M. List, C. Kiel, A. I. Casas, Harald H. H. W. Schmidt   +5 more
semanticscholar   +5 more sources

Network pharmacology: a bright guiding light on the way to explore the personalized precise medication of traditional Chinese medicine

Chinese Medicine, 2023
Network pharmacology can ascertain the therapeutic mechanism of drugs for treating diseases at the level of biological targets and pathways. The effective mechanism study of traditional Chinese medicine (TCM) characterized by multi-component, multi ...
Ling Li, Lele Yang, Liuqing Yang, Chunrong He, Yuxin He, Liping Chen, Qin Dong, Huaiying Zhang, Shiyun Chen, Peng Li   +9 more
doaj   +2 more sources

Tinnitus: Network pathophysiology-network pharmacology [PDF]

Frontiers in Systems Neuroscience, 2012
Tinnitus, the phantom perception of sound, is a prevalent disorder. One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant unmet clinical need for a safe
Ana Belen eElgoyhen, Berthold eLangguth, Sven eVanneste, Dirk eDe Ridder   +3 more
doaj   +4 more sources

Network pharmacology: a crucial approach in traditional Chinese medicine research

Chinese Medicine
Network pharmacology plays a pivotal role in systems biology, bridging the gap between traditional Chinese medicine (TCM) theory and contemporary pharmacological research.
Yiyan Zhai, Liu Liu, Fanqin Zhang, Xiaodong Chen, Haojia Wang, Jiying Zhou, Keyan Chai, Jiangying Liu, Huiling Lei, Peiying Lu, Meiling Guo, Jincheng Guo, Jiarui Wu   +12 more
doaj   +2 more sources

Progress and Prospects of Research Ideas and Methods in the Network Pharmacology of Traditional Chinese Medicine

Journal of Pharmacy & Pharmaceutical Sciences, 2022
In recent years, the emerging network pharmacology has been extensively applied to the field of traditional Chinese medicine and has made great contributions to the modernization of TCM.
Zhongzhu Yuan, Yingying Pan , Tian Leng, Yu Chu, Haojie Zhang, Jingru Ma, Xiaoju Ma   +6 more
doaj   +2 more sources

Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment

Frontiers in Pharmacology, 2019
The research field of systems biology has greatly advanced and, as a result, the concept of network pharmacology has been developed. This advancement, in turn, has shifted the paradigm from a “one-target, one-drug” mode to a “network-target, multiple ...
Runzhi Zhang, Xue Zhu, Hong Bai, Kang Ning   +3 more
doaj   +2 more sources

Network Pharmacology Approach for Medicinal Plants: Review and Assessment

Pharmaceuticals, 2022
Natural products have played a critical role in medicine due to their ability to bind and modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive scaffolds for the treatment of multiple disorders.
Fatima Noor, Muhammad Tahir ul Qamar, Usman Ali Ashfaq, Aqel Albutti, Ameen S. S. Alwashmi, Mohammad Abdullah Aljasir   +5 more
doaj   +2 more sources

Application of network pharmacology in traditional Chinese medicine for the treatment of cardiac diseases [PDF]

Frontiers in Pharmacology
Many innovative traditional Chinese medicines (TCMs) play a significant role in cardioprotection against cardiac diseases by addressing the basic causes of heart attack, which presents as a dual deficiency of qi and yang. Network pharmacology, offering a
Xi Zhai, Xi Zhai, Xi Zhai, Xi Zhai, Xingyu Chen, Xingyu Chen, Xingyu Chen, Xiao Xiao, Xiao Xiao, Xiao Xiao, Lan Wu, Lan Wu, Lan Wu   +12 more
doaj   +2 more sources

Analyzing the research landscape: Mapping frontiers and hot spots in anti-cancer research using bibliometric analysis and research network pharmacology

Frontiers in Pharmacology, 2023
Introduction: Network pharmacology has emerged as a forefront and hotspot in anti-cancer. Traditional anti-cancer drugs are limited by the paradigm of “one cancer, one target, one drug,” making it difficult to address the challenges of recurrence and ...
Qi Han, Qi Han, Zhongxun Li, Zhongxun Li, Yang Fu, Hongliang Liu, Hongliang Liu, Hongliang Liu, Hongliang Liu, Huina Guo, Huina Guo, Xiaoya Guan, Xiaoya Guan, Min Niu, Min Niu, Chunming Zhang, Chunming Zhang, Chunming Zhang   +17 more
doaj   +2 more sources

Research trends and hotspots of neurodegenerative diseases employing network pharmacology: A bibliometric analysis

Frontiers in Pharmacology, 2023
Background: Employing network pharmacology in neurodegenerative diseases (NDs) has been extensively studied recently. However, no comprehensive study has conducted on this subject employing bibliometrics so far.
Jie Zhu, Qingchun Liang, Siyi He, Chen Wang, Xiafei Lin, Duozhi Wu, Guanwen Lin, Zhihua Wang   +7 more
doaj   +1 more source