Frontiers in Pharmacology, 2021 Myocardial ischemia (MI) is one of the most common cardiovascular diseases with high incidence and mortality. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic traditional Chinese prescription to clear “heat” and “poison”.
Li Li +8 more
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iMeta, 2022 DNA‐based biological ingredient identification and downstream pharmacology network analysis are commonly used in research for Traditional Chinese Medicine preparations (TCM formulas).
Pengshuo Yang +8 more
doaj +1 more source
Personalized medicine : the impact on chemistry [PDF]
, 2010 An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew +3 more
core +1 more source
Network pharmacology approach to screen hypoglycemic extracts from Coptidis rhizoma and study their targets and pathways [PDF]
, 2022 Purpose: To screen the hypoglycemic active ingredients of Coptidis rhizoma, and study their targets as well as signal pathways via network pharmacology. Methods: Fifty-nine ingredients of Coptidis rhizoma were screened.
Huang, He-gui +7 more
core +3 more sources
Identification of the anti-COVID-19 mechanism of action of Han-Shi Blocking Lung using network pharmacology-integrated molecular docking [PDF]
, 2022 Purpose: To investigate the bio-active components and the potential mechanism of the prescription remedy, Han-Shi blocking lung, with network pharmacology with a view to expanding its application.
Chen, Peng-Yu +5 more
core +2 more sources
Best practices to maximize the use and reuse of quantitative and systems pharmacology models: recommendations from the United Kingdom quantitative and systems pharmacology network [PDF]
, 2018 The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts.
Amy Cheung, S. Y. +12 more
core +3 more sources
The Complex Structure of the Pharmacological Drug–Disease Network [PDF]
Entropy, 2021 The complexity of drug–disease interactions is a process that has been explained in terms of the need for new drugs and the increasing cost of drug development, among other factors. Over the last years, diverse approaches have been explored to understand drug–disease relationships. Here, we construct a bipartite graph in terms of active ingredients and
Irene López-Rodríguez +3 more
openaire +3 more sources
A visual analysis of network pharmacology research trends
World Journal of Traditional Chinese Medicine, 2018 Objective: To understand the current situation of network pharmacology, and to analyze external and internal characteristics of literature, is of great significance for the development of network pharmacology in the future and its application in the ...
Shen Xiao +8 more
doaj +1 more source
Frontiers in Plant Science, 2022 Anisodus tanguticus (Maxim.) Pascher, has been used for the treatment of septic shock, analgesia, motion sickness, and anesthesia in traditional Tibetan medicine for 2,000 years.
Chen Chen +6 more
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Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters [PDF]
Current Pharmaceutical Design, 2013, 19, 4155-4172, 2012 The ABC (ATP Binding Cassette) transporter protein superfamily comprises a large number of ubiquitous and functionally versatile proteins conserved from archaea to humans. ABC transporters have a key role in many human diseases and also in the development of multidrug resistance in cancer and in parasites. Although a dramatic progress has been achieved
arxiv +1 more source