Frontiers in Plant Science, 2022 Anisodus tanguticus (Maxim.) Pascher, has been used for the treatment of septic shock, analgesia, motion sickness, and anesthesia in traditional Tibetan medicine for 2,000 years.
Chen Chen +6 more
doaj +1 more source
The Scientific Competitiveness of Nations [PDF]
, 2014 We use citation data of scientific articles produced by individual nations in different scientific domains to determine the structure and efficiency of national research systems.
Cimini, Giulio +2 more
core +3 more sources
Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain [PDF]
, 2012 The development of clinica lpractice recommendations or guidelines for the clinical use of biomarkers is an issue of great importance withr regard to adverse drug reactions.The poten-tial of pharmacogenomicbiomarkers has been extensively investigated in
Abad Santos, Francisco +18 more
core +4 more sources
Pharmacological mechanism of JiaWeiSiWu granule in the treatment of hypertension based on network pharmacology [PDF]
Annals of Palliative Medicine, 2021 JiaWeiSiWu granule (JWSWG) has been applied clinically for more than a decade, and the preliminary results show that blood pressure can be reduced while protecting the target organ at the same time. The purpose of this research is to study the pharmacological mechanism of JWSWG in treating hypertension using network pharmacology.The chief active ...
Zigang Zhang +5 more
openaire +2 more sources
Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]
, 2014 Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention.
Bown, James L. +4 more
core +4 more sources
Single prazosin infusion in prelimbic cortex Fosters extinction of amphetamine-induced conditioned place preference [PDF]
, 2017 Exposure to drug-associated cues to induce extinction is a useful strategy to contrast cue-induced drug seeking. Norepinephrine (NE) transmission in medial prefrontal cortex has a role in the acquisition and extinction of conditioned place preference ...
Alessandro Rava +8 more
core +4 more sources
Boolean network modeling in systems pharmacology [PDF]
Journal of Pharmacokinetics and Pharmacodynamics, 2018 Quantitative systems pharmacology (QSP) is an emerging discipline that aims to discover how drugs modulate the dynamics of biological components in molecular and cellular networks and the impact of those perturbations on human pathophysiology. The integration of systems-based experimental and computational approaches is required to facilitate the ...
Peter Bloomingdale +3 more
openaire +3 more sources
Network Pharmacology‐Based Analysis of the Pharmacological Mechanisms of Aloperine on Cardiovascular Disease [PDF]
Evidence-Based Complementary and Alternative Medicine, 2020 Background. Aloperine is an active component of Sophora alopecuroides Linn, which has been extensively applied for the treatment of cardiovascular disease (CVD). However, our current understanding of the molecular mechanisms supporting the effects of aloperine on CVD remains unclear. Methods.
Bingwu Huang +4 more
openaire +3 more sources
The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology
Biomolecules, 2019 Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM.
Won-Yung Lee +3 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Network pharmacology is considered as the next paradigm in drug discovery. In an era when obesity has become global epidemic, network pharmacology becomes an ideal tool to discover novel herbal-based therapeutics with effective anti-obesity effects ...
Ying Wang +6 more
doaj +1 more source