Results 31 to 40 of about 337,823 (305)
Frontiers in Plant Science, 2022 Anisodus tanguticus (Maxim.) Pascher, has been used for the treatment of septic shock, analgesia, motion sickness, and anesthesia in traditional Tibetan medicine for 2,000 years.
Chen Chen +6 more
doaj +1 more source
Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations [PDF]
, 2014 Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention.
Bown, James L. +4 more
core +5 more sources
Boolean network modeling in systems pharmacology [PDF]
Journal of Pharmacokinetics and Pharmacodynamics, 2018 Quantitative systems pharmacology (QSP) is an emerging discipline that aims to discover how drugs modulate the dynamics of biological components in molecular and cellular networks and the impact of those perturbations on human pathophysiology. The integration of systems-based experimental and computational approaches is required to facilitate the ...
Peter Bloomingdale +3 more
openaire +2 more sources
Network Pharmacology and Pharmacological Mechanism of CV-3 in Atrial Fibrillation
Evidence-Based Complementary and Alternative Medicine, 2022 The high fatality and disability rate of atrial fibrillation (AF) strongly promote the development of pathogenesis and treatment of AF that is of great value. The present research attempted to clarify potential mechanisms of Mujiangzi oil (CV-3) in treating AF by constructing an AF cardiomyocytes model and using a network pharmacology approach.
Zundong Wang +5 more
openaire +2 more sources
Pharmacotherapy and Pregnancy: Highlights from the Third International Conference for Individualized Pharmacotherapy in Pregnancy [PDF]
, 2011 To address provider struggles to provide evidence-based, rational drug therapy to pregnant women, this third Conference was convened to highlight the current progress and research in the field.
Clark, Shannon M. +15 more
core +2 more sources
A network inference method for large-scale unsupervised identification of novel drug-drug interactions [PDF]
, 2013 Characterizing interactions between drugs is important to avoid potentially harmful combinations, to reduce off-target effects of treatments and to fight antibiotic resistant pathogens, among others.
Guimera, Roger, Sales-Pardo, Marta
core +4 more sources
Bioscience Reports, 2022 Abstract Objective: Andrographis paniculata (Burm.f.) Nees is a medicinal plant that has been traditionally used as an anti-inflammatory and antibacterial remedy for several conditions. Andrographolide (AG), the active constituent of A. paniculata (Burm.f.) Nees, has anti-lipidic and anti-inflammatory properties as well as cardiovascular
Shuai Shi +8 more
openaire +2 more sources
The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology
Biomolecules, 2019 Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM.
Won-Yung Lee +3 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Network pharmacology is considered as the next paradigm in drug discovery. In an era when obesity has become global epidemic, network pharmacology becomes an ideal tool to discover novel herbal-based therapeutics with effective anti-obesity effects ...
Ying Wang +6 more
doaj +1 more source
, 2017 The one-drug/one-target/one-disease approach to drug discovery is presently facing many challenges of safety, efficacy, and sustainability. Network biology and polypharmacology approaches gained appreciation recently as methods for omics data integration and multitarget drug development, respectively.
Chandran, Uma +4 more
openaire +1 more source