Results 41 to 50 of about 7,014,814 (396)

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]

, 2019
Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J, Hampel, Harald, Kapogiannis, Dimitrios, Lista, Simone, Vergallo, Andrea   +4 more
core   +2 more sources

INPUT: An intelligent network pharmacology platform unique for traditional Chinese medicine

Computational and Structural Biotechnology Journal, 2022
The application of network pharmacology has greatly promoted the scientific interpretation of disease treatment mechanism of traditional Chinese medicine (TCM).
Xianhai Li, Qiang Tang, Fanbo Meng, Pufeng Du, Wei Chen   +4 more
doaj  

Network Pharmacology‐Based Analysis of the Pharmacological Mechanisms of Aloperine on Cardiovascular Disease [PDF]

Evidence-Based Complementary and Alternative Medicine, 2020
Background. Aloperine is an active component of Sophora alopecuroides Linn, which has been extensively applied for the treatment of cardiovascular disease (CVD). However, our current understanding of the molecular mechanisms supporting the effects of aloperine on CVD remains unclear. Methods.
Bingwu Huang, Juncheng Xiong, Xuyong Zhao, Yihan Zheng, Ning Zhu   +4 more
openaire   +3 more sources

Pharmacological mechanism of JiaWeiSiWu granule in the treatment of hypertension based on network pharmacology [PDF]

Annals of Palliative Medicine, 2021
JiaWeiSiWu granule (JWSWG) has been applied clinically for more than a decade, and the preliminary results show that blood pressure can be reduced while protecting the target organ at the same time. The purpose of this research is to study the pharmacological mechanism of JWSWG in treating hypertension using network pharmacology.The chief active ...
Zigang Zhang, Lun Chen, Haitao Liu, Tong Zhu, Jia Qi, Yufeng Zhang   +5 more
openaire   +2 more sources

Cost-Utility Analysis of Venous Thromboembolism Prophylaxis Strategies for People Undergoing Elective Total Hip and Total Knee Replacement Surgeries in the English National Health Service [PDF]

, 2018
Background: Major orthopedic surgery, such as elective total hip replacement (eTHR) and elective total knee replacement (eTKR), are associated with a higher risk of venous thromboembolism (VTE) than other surgical procedures.
Anderson, Annemans, Arya, Barco, Bischof, Bjorvatn, Botteman, Braidy, Brockbank, Capri, Caprini, Cohoon, Curtis, Dahl, Dahl, Davies, Diamantopoulos, Dranitsaris, Dranitsaris, Ende-Verhaar, Gomez-Outes, Gordois, Gould, Haentjens, Hamidi, Hauck, Heit, Husereau, Jameson, Jameson, Kahn, Kapoor, Lundkvist, McCullagh, McCullagh, McDonald, Migliaccio-Walle, Postma, Quinlan, Reeves, Revankar, Riemsma, Roberts, Ryttberg, Sterne, Stevenson, Wade, Wang, Warwick, White, Wille-Jørgensen, Wolowacz, Wolowacz, Zindel   +53 more
core   +4 more sources

Integrated lipidomics and network pharmacology analysis to reveal the mechanisms of berberine in the treatment of hyperlipidemia

Journal of Translational Medicine, 2022
Berberine (BBR), an isoquinoline alkaloid isolated from Rhizoma Coptis, is widely used in the treatment of hyperlipidemia (HLP) in China. At present, the efficacy of BBR against HLP is relatively clear, but there are few researches on its mechanism.
Yuting Chen, Kaipeng Li, Han Zhao, Zhan-Xi Hao, Yuxin Yang, Mingming Gao, Ding Zhao   +6 more
semanticscholar   +1 more source

Boolean network modeling in systems pharmacology [PDF]

Journal of Pharmacokinetics and Pharmacodynamics, 2018
Quantitative systems pharmacology (QSP) is an emerging discipline that aims to discover how drugs modulate the dynamics of biological components in molecular and cellular networks and the impact of those perturbations on human pathophysiology. The integration of systems-based experimental and computational approaches is required to facilitate the ...
Peter Bloomingdale, Van Anh Nguyen, Jin Niu, Donald E. Mager   +3 more
openaire   +3 more sources

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands [PDF]

, 2015
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and potential drugs and their targets in the human genome.
Adam J. Pawson, Anthony P. Davenport, Christopher Southan, Doriano Fabbro, Elena Faccenda, Helen E. Benson, Jamie A. Davies, Joanna L. Sharman, John A. Peters, John C. McGrath, Knapp, Li, Mathias, Michael Spedding, O. Peter Buneman, Stephen P. H. Alexander, Tough, William A. Catterall   +17 more
core   +5 more sources

The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology

Biomolecules, 2019
Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM.
Won-Yung Lee, Choong-Yeol Lee, Youn-Sub Kim, Chang-Eop Kim   +3 more
doaj   +1 more source

Network Pharmacology-Based Strategy for the Investigation of the Anti-Obesity Effects of an Ethanolic Extract of Zanthoxylum bungeanum Maxim

Frontiers in Pharmacology, 2020
Network pharmacology is considered as the next paradigm in drug discovery. In an era when obesity has become global epidemic, network pharmacology becomes an ideal tool to discover novel herbal-based therapeutics with effective anti-obesity effects ...
Ying Wang, Song Hong Yang, Keying Zhong, Ting Jiang, Mi Zhang, Hiu Yee Kwan, Tao Su   +6 more
doaj   +1 more source