Results 41 to 50 of about 334,131 (356)

Network Pharmacology

, 2017
The one-drug/one-target/one-disease approach to drug discovery is presently facing many challenges of safety, efficacy, and sustainability. Network biology and polypharmacology approaches gained appreciation recently as methods for omics data integration and multitarget drug development, respectively.
Saniya Patil, Rathnam Chaguturu, Neelay Mehendale, Bhushan Patwardhan, Uma Chandran   +4 more
openaire   +2 more sources

Molecular networks for the study of TCM Pharmacology [PDF]

Briefings in Bioinformatics, 2009
To target complex, multi-factorial diseases more effectively, there has been an emerging trend of multi-target drug development based on network biology, as well as an increasing interest in traditional Chinese medicine (TCM) that applies a more holistic treatment to diseases.
Peng Jiang, Wei-Dong Zhang, Jing Zhao
openaire   +3 more sources

Combining metabolomics and network pharmacology to investigate the protective effect of Jiawei Xinglou Chengqi Granules in ischemic stroke [PDF]

Brazilian Journal of Medical and Biological Research
Jiawei Xinglou Chengqi Granule (JXCG) is an effective herbal medicine for the treatment of ischemic stroke (IS). JXCG has been shown to effectively ameliorate cerebral ischemic symptoms in clinical practice, but the underlying mechanisms are unclear.
Raoqiong Wang, Linshen Mao, Pan Liang, Yulu Gan, Qixue Gao, Shizhi Liang, Dechou Zhang, Gang Luo, Sijin Yang   +8 more
doaj   +1 more source

Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation

Bioscience Reports, 2022
Abstract Objective: Andrographis paniculata (Burm.f.) Nees is a medicinal plant that has been traditionally used as an anti-inflammatory and antibacterial remedy for several conditions. Andrographolide (AG), the active constituent of A. paniculata (Burm.f.) Nees, has anti-lipidic and anti-inflammatory properties as well as cardiovascular
Shuai Shi, Xinyu Ji, Jingjing Shi, Shuqing Shi, Fei She, Qiuyan Zhang, Yu Dong, Hanming Cui, Yuanhui Hu   +8 more
openaire   +2 more sources

Network Pharmacology Approach for Medicinal Plants: Review and Assessment

Pharmaceuticals, 2022
Natural products have played a critical role in medicine due to their ability to bind and modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive scaffolds for the treatment of multiple disorders.
Fatima Noor, Muhammad Tahir ul Qamar, Usman Ali Ashfaq, Aqel Albutti, Ameen S. S. Alwashmi, Mohammad Abdullah Aljasir   +5 more
doaj   +1 more source

Integrative transcriptomic and network pharmacology analysis reveals the neuroprotective role of BYHWD through enhancing autophagy by inhibiting Ctsb in intracerebral hemorrhage mice

Chinese Medicine, 2023
Background In this study, we aimed to combine transcriptomic and network pharmacology to explore the crucial mRNAs and specific regulatory molecules of Buyang Huanwu Decoction (BYHWD) in intracerebral hemorrhage (ICH) treatment. Methods C57BL/6 mice were
Yiqing Cai, Zhe Yu, Xueping Yang, Weikang Luo, En Hu, Teng Li, Wenxin Zhu, Yang Wang, Tao Tang, Jiekun Luo   +9 more
doaj   +1 more source

Assessing the 2004-2018 fentanyl misusing issues reported to an international range of adverse reporting systems [PDF]

, 2019
© 2019 Schifano, Chiappini, Corkery and Guirguis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Chiappini, Stephania, Corkery, John, Guirguis, Amira, Schifano, Fabrizio   +3 more
core   +4 more sources

The heterogeneous pharmacological medical biochemical network PharMeBINet

Scientific Data, 2022
AbstractHeterogeneous biomedical pharmacological databases are important for multiple fields in bioinformatics. Hetionet is a freely available database combining diverse entities and relationships from 29 public resources. Therefore, it is used as the basis for this project.
Königs, Cassandra, Friedrichs, Marcel, Dietrich, Theresa   +2 more
openaire   +3 more sources

Integrating metabolomics and network pharmacology to assess the effects of quercetin on lung inflammatory injury induced by human respiratory syncytial virus

Scientific Reports, 2023
Quercetin (QR) has significant anti-respiratory syncytial virus (RSV) effects. However, its therapeutic mechanism has not been thoroughly explored. In this study, a lung inflammatory injury model caused by RSV was established in mice.
Ya-Lei Sun, Pei-Pei Zhao, Cheng-Bi Zhu, Ming-Chen Jiang, Xin-Min Li, Jia-Lei Tao, Chan-Chan Hu, Bin Yuan   +7 more
doaj   +1 more source

Analyzing the research landscape: Mapping frontiers and hot spots in anti-cancer research using bibliometric analysis and research network pharmacology

Frontiers in Pharmacology, 2023
Introduction: Network pharmacology has emerged as a forefront and hotspot in anti-cancer. Traditional anti-cancer drugs are limited by the paradigm of “one cancer, one target, one drug,” making it difficult to address the challenges of recurrence and ...
Qi Han, Qi Han, Zhongxun Li, Zhongxun Li, Yang Fu, Hongliang Liu, Hongliang Liu, Hongliang Liu, Hongliang Liu, Huina Guo, Huina Guo, Xiaoya Guan, Xiaoya Guan, Min Niu, Min Niu, Chunming Zhang, Chunming Zhang, Chunming Zhang   +17 more
doaj   +1 more source