Results 41 to 50 of about 628,285 (376)
Allo-network drugs: harnessing allostery in cellular networks [PDF]
Trends in Pharmacological Sciences (2011) 32, 686-693, 2011 Allosteric drugs are increasingly used because they produce fewer side effects. Allosteric signal propagation does not stop at the 'end' of a protein, but may be dynamically transmitted across the cell. Here, we propose that the concept of allosteric drugs can be broadened to allo-network drugs, whose effects can propagate either within a protein, or ...
arxiv +1 more source
Pharmacological mechanism of JiaWeiSiWu granule in the treatment of hypertension based on network pharmacology [PDF]
Annals of Palliative Medicine, 2021 JiaWeiSiWu granule (JWSWG) has been applied clinically for more than a decade, and the preliminary results show that blood pressure can be reduced while protecting the target organ at the same time. The purpose of this research is to study the pharmacological mechanism of JWSWG in treating hypertension using network pharmacology.The chief active ...
Zigang Zhang +5 more
openaire +2 more sources
INPUT: An intelligent network pharmacology platform unique for traditional Chinese medicine
Computational and Structural Biotechnology Journal, 2022 The application of network pharmacology has greatly promoted the scientific interpretation of disease treatment mechanism of traditional Chinese medicine (TCM).
Xianhai Li +4 more
doaj
Boolean network modeling in systems pharmacology [PDF]
Journal of Pharmacokinetics and Pharmacodynamics, 2018 Quantitative systems pharmacology (QSP) is an emerging discipline that aims to discover how drugs modulate the dynamics of biological components in molecular and cellular networks and the impact of those perturbations on human pathophysiology. The integration of systems-based experimental and computational approaches is required to facilitate the ...
Peter Bloomingdale +3 more
openaire +3 more sources
Network Pharmacology‐Based Analysis of the Pharmacological Mechanisms of Aloperine on Cardiovascular Disease [PDF]
Evidence-Based Complementary and Alternative Medicine, 2020 Background. Aloperine is an active component of Sophora alopecuroides Linn, which has been extensively applied for the treatment of cardiovascular disease (CVD). However, our current understanding of the molecular mechanisms supporting the effects of aloperine on CVD remains unclear. Methods.
Bingwu Huang +4 more
openaire +3 more sources
A comparison of reimbursement recommendations by European HTA agencies : Is there opportunity for further alignment? [PDF]
, 2017 Introduction: In Europe and beyond, the rising costs of healthcare and limited healthcare resources have resulted in the implementation of health technology assessment (HTA) to inform health policy and reimbursement decision-making.
Allen +13 more
core +10 more sources
Frontiers in Pharmacology, 2020 Network pharmacology is considered as the next paradigm in drug discovery. In an era when obesity has become global epidemic, network pharmacology becomes an ideal tool to discover novel herbal-based therapeutics with effective anti-obesity effects ...
Ying Wang +6 more
doaj +1 more source
How Can Network-Pharmacology Contribute to Antiepileptic Drug Development? [PDF]
, 2014 Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of exquisitely selective drugs. What is
Di Ianni, Mauricio Emiliano +1 more
core +3 more sources
The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology
Biomolecules, 2019 Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM.
Won-Yung Lee +3 more
doaj +1 more source
, 2017 The one-drug/one-target/one-disease approach to drug discovery is presently facing many challenges of safety, efficacy, and sustainability. Network biology and polypharmacology approaches gained appreciation recently as methods for omics data integration and multitarget drug development, respectively.
Saniya Patil +4 more
openaire +2 more sources