Results 101 to 110 of about 6,797,677 (284)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
U.S. Telecommunications Today, April 1999 [PDF]
This short essay examines the current conditions in the US telecommunications sector (April 1999). We examine the impact of technological and regulatory change on market structure and business strategy.
Nicholas Economides
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Dizhen xuebao鲁东—黄海地块西部为华北地块东侧的次级地块，其地震活动具有显著的周期特征，地块内部的中强地震活动特征和周边大震对该地区的影响对研究该地区地震活动状态有重要意义。采用小波分析方法定量计算了鲁东—黄海地块西部历史地震的活动周期，并结合中强地震活动的定性分析、时空演化、能量释放及周边大震等资料，探讨了该地区的地震活动特征。结果显示：① 鲁东—黄海地块西部M5.0以上地震活动存在着60.6—78.6 a的长周期，该周期反映了地震活跃—平静的韵律特征，据此M≥5.0地震可划分为活跃时段 Ⅰ （1844—1879年）
Mingxiao Li +6 more
doaj +1 more source
Two-sided competition of proprietary vs. open source technology platforms, and the implications for the software industry [PDF]
Technology platforms, such as Microsoft Windows, are the hubs of technology industries. We develop a framework to characterize the optimal two-sided pricing strategy of a platform firm, that is, the pricing strategy towards the direct users of the ...
Evangelos Katsamakas +1 more
core
Immunization of networks with community structure
, 2009 In this study, an efficient method to immunize modular networks (i.e., networks with community structure) is proposed. The immunization of networks aims at fragmenting networks into small parts with a small number of removed nodes.
+12 more
core +2 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Linux vs. Windows: A comparison of application and platform innovation incentives for open source and proprietary software platforms+ [PDF]
The paper analyzes and compares the investment incentives of platform and application developers for Linux and Windows. We find that the level of investment in applications is larger when the operating system is open source rather than proprietary.
Evangelos Katsamakas +1 more
core
Contagion on complex networks with persuasion
, 2016 The threshold model has been widely adopted as a classic model for studying contagion processes on social networks. We consider asymmetric individual interactions in social networks and introduce a persuasion mechanism into the threshold model ...
Fu, Xinchu +3 more
core +1 more source
Networks, NetWorks, NETWorks, NETWORKS
, 1997 Business networks are having different characteristics and building blocs when looked upon from diverse perspectives. In this paper the aim is to highlight some aspects of the multi-facetted nature of business networks in marketing between industrial companies especially. A model is used as a base for discussing different networks in business settings.
openaire +1 more source