Results 81 to 90 of about 16,068 (197)

Theoretical Studies on the Electronic Structure Parameters and Reactive Activity of Neu5Gc and Neu5Ac under Food Processing Solvent Environment

Molecules, 2019
The animal product hazard factor N-glycolylneuraminic (Neu5Gc) and brain nutrient substance N-acetylneuraminic acid (Neu5Ac) were studied at the M062X/6-311 + G(d,p) geometry optimization level.
Rui Chang, Bowen Yang, Qiu-Jin Zhu
doaj   +1 more source

Electrochemical Evaluation of Tumor Development via Cellular Interface Supported CRISPR/Cas Trans-Cleavage

Research, 2022
Evaluating tumor development is of great importance for clinic treatment and therapy. It has been known that the amounts of sialic acids on tumor cell membrane surface are closely associated with the degree of cancerization of the cell. So, in this work,
Liangfen Cheng, Fuhan Yang, Longfei Tang, Lelin Qian, Xu Chen, Feng Guan, Juan Zhang, Genxi Li   +7 more
doaj   +1 more source

LC-MS/MS Isomeric Profiling of N-Glycans Derived from Low-Abundant Serum Glycoproteins in Mild Cognitive Impairment Patients

Biomolecules, 2022
Mild cognitive impairment (MCI) is an early stage of memory loss that affects cognitive abilities, such as language or virtual/spatial comprehension. This cognitive decline is mostly observed with the aging of individuals.
Cristian D. Gutierrez Reyes, Md. Abdul Hakim, Mojgan Atashi, Mona Goli, Sakshi Gautam, Junyao Wang, Andrew I. Bennett, Jianhui Zhu, David M. Lubman, Yehia Mechref   +9 more
doaj   +1 more source

Growth of bifidobacteria in mammalian milk [PDF]

, 2013
Microbial colonization of the mammalian intestine begins at birth, when from a sterile state a newborn infant is exposed to an external environment rich in various bacterial species.
Bunešová, V., Havlik, J., Janda, K., Profousová, L., Rada, V., Ročková, Š, Vlková, E., Švejstil, R.   +7 more
core   +1 more source

Absolute bioavailability and intravenous pharmacokinetics of N‐acetyl‐D‐mannosamine in humans

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 488-494, February 2026.
Aims N‐acetyl‐D‐mannosamine monohydrate (ManNAc) is a naturally occurring monosaccharide that has attracted considerable attention for its potential in treating GNE myopathy, a rare autosomal recessive muscle disorder. Despite its promise as an oral treatment, the absolute bioavailability of oral ManNAc has not been determined and there has been no ...
Tahlia R. Meola, Guy Ludbrook, Gianfranco Fornasini, Olga Pavlova, Sumit Jain, Allan M. Evans, Stephanie E. Reuter   +6 more
wiley   +1 more source

Molecular Characterization of a Novel N-Acetylneuraminate Lyase from a Deep-Sea Symbiotic Mycoplasma

Marine Drugs, 2018
N-acetylneuraminic acid (Neu5Ac) based novel pharmaceutical agents and diagnostic reagents are highly required in medical fields. However, N-acetylneuraminate lyase（NAL）for Neu5Ac synthesis is not applicable for industry due to its low catalytic ...
Shao-lu Wang, Yun-liang Li, Zhuang Han, Xi Chen, Qi-jia Chen, Yong Wang, Li-sheng He   +6 more
doaj   +1 more source

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site [PDF]

, 2018
Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic ...
Abramson, Jeff,, Andersson, Rebecka,, Beis, Konstantinos,, Bengtsson-Palme, Johan,, Bisignano, Paola,, Caing-Carlsson, Rhawnie,, Claesson, Elin,, Dobson, Renwick C.J.,, Dunevall, Elin,, Farewell, Anne,, Friemann, Rosmarie,, Goyal, Parveen,, Grabe, Michael,, Indiveri, Cesare,, Lund University., Nilsson, Ulf J.,, North, Rachel A.,, Paz, Aviv,, Pochini, Lorena,, Ramaswamy, S.,, Scalise, Mariafrancesca,, Wahlgren, Weixiao Y.,   +21 more
core   +3 more sources

Metabolomic Insights Into the Impact of a Maternal Western‐Style Diet and Leptin Supplementation During Suckling on Adult Rat Offspring

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Plasma metabolites in adult offspring reflecting metabolic programming during critical developmental windows. ABSTRACT Perinatal nutrition influences offspring metabolic phenotype and obesity risk. This study examines how a maternal obesogenic diet and offspring's leptin supplementation during suckling affect the metabolome in offspring adulthood ...
Catalina A. Pomar, Rocío A. Martin‐Chamorro, Petr Zouhar, Pedro Castillo, Tomas Cajka, Jan Kopecky, Andreu Palou, Mariona Palou, Catalina Picó   +8 more
wiley   +1 more source

Distribution of sialoglycoconjugates in the oviductal isthmus of the horse during anoestrus, oestrus and pregnancy: a lectin histochemistry study

European Journal of Histochemistry, 2009
The distribution of sialic acid residues as well as other glycosidic sugars has been investigated in the horse oviductal isthmus during anoestrus, oestrus and pregnancy by means of lectin and pre-lectin methods. Ciliated cells and non-ciliated (secretory)
S Desantis, F Acone, A Corriero
doaj   +1 more source

Expression of sialic acids and other nonulosonic acids in Leptospira [PDF]

, 2012
BackgroundSialic acids are negatively charged nine carbon backbone sugars expressed on mammalian cell surfaces. Sialic acids are part of a larger family of nonulosonic acid (NulO) molecules that includes pseudaminic and legionaminic acids.
Lewis, Amanda L, Matthias, Michael A, Ricaldi, Jessica N, Vinetz, Joseph M   +3 more
core   +3 more sources