Results 61 to 70 of about 1,943 (161)
Visualizing of sialidase activities in rat brain slices with BTP-Neu5Ac.
, 2014 A–C, Sialidase activity was imaged in acute coronal slices of adult rat brains with BTP2-Neu5Ac (A), BTP3-Neu5Ac (B) and BTP4-Neu5Ac (C) at pH 7.3. Abbreviations: cc, corpus callosum; ec, external capsule; fi, fimbria; hip, hippocampus; ic, internal ...
Tsunehiro Yokochi (508351) +13 more
core +1 more source
PLoS ONE, 2018 BackgroundSialylated glycoconjugates play important roles in physiological and pathological processes. However, available sialylated oligosaccharides source is limited which is a barrier to study their biological roles.
Jie Zeng +9 more
doaj +1 more source
Preferential Accumulation of 14C-N-Glycolylneuraminic Acid over 14C-N-Acetylneuraminic Acid in the Rat Brain after Tail Vein Injection. [PDF]
PLoS ONE, 2015 The two main molecular species of sialic acid existing in nature are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). Neu5Ac is abundant in mammalian brains and plays crucial roles in many neural functions.
Risa Taguchi +6 more
doaj +1 more source
Chemistry of N-Acetylneuraminic Acid (Neu5Ac)
Trends in Glycoscience and Glycotechnology, 2004 シアル酸 (Neu5Ac, Neu5Gc, andKDN) は単糖の中で最も複雑な構造もつ化合物である。シアル酸は分子量320程度の小さな分子にもかかわらず多くの官能基から構成されている。またそれらの官能基が条件によって糖特有の平衡状態とる。このことがシアル酸の合成化学を始めるにあたり難くしている。シアル酸は種々の試薬に大変敏感に反応する性質を持っているので、目的化合物を合成するには経験的な反応条件が必要となる。ここでは、既に報告されている沢山の論文の中からシアル酸の中で最も代表的なN-アセチルノイラミン酸についてNeu5Ac特有の反応と基本的な反応の紹介と、簡単な反応によるNeu5Acの挙動からその化学的な多様性について述べる。
openaire +2 more sources
Post-Glycosylation Modification of Sialic Acid and Its Role in Virus Pathogenesis
Vaccines, 2019 Sialic acids are a family of nine carbon keto-aldononulosonic acids presented at the terminal ends of glycans on cellular membranes. α-Linked sialoglycoconjugates often undergo post-glycosylation modifications, among which O-acetylation of N-acetyl ...
Simon S. Park
doaj +1 more source
Haematologica, 2020 Aberrant glycosylation resulting from altered expression of sialyltransferases, such as ST3 β-galactoside α2-3-sialyltransferase 6, plays an important role in disease progression in multiple myeloma (MM).
Alessandro Natoni +7 more
doaj +1 more source
Journal of Biomedical Materials Research Part A, Volume 114, Issue 9, September 2026.ABSTRACT Type I collagen (Col‐I) is widely used in biomaterials and cell biology, yet the glycosignature of commercial Col‐I preparations remains poorly characterized. Here, we established an integrated lectin‐based workflow to profile the glycan landscape of commercially sourced bovine pepsin‐soluble Col‐I as supplied for biomaterial use.
Mohamed EL‐Melegy +2 more
wiley +1 more source
Ferroptosis: Newly Emerged Regulator for Human Disease
MedComm, Volume 7, Issue 9, September 2026.Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao +4 more
wiley +1 more source
Results of precision for the proposed method to determine Neu5Ac level.
, 2022 Results of precision for the proposed method to determine Neu5Ac level.
Hyo Jeong Kim (7490237) +3 more
core +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.ST6GAL1 sialylates glycoconjugates in the Golgi, modulating immune recognition and enabling tumor immune evasion. To effectively reach ST6GAL1, inhibitors should demonstrate good membrane permeability. Based on nonpermeable hit JFD 00458, we developed sulfonylurea analogs achieving increased membrane permeability and potency.
Natan Koraj +9 more
wiley +1 more source