Results 51 to 60 of about 1,943 (161)

Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection. [PDF]

PLoS Pathogens, 2012
The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals.
Ursula Neu, Holger Hengel, Bärbel S Blaum, Rachel M Schowalter, Dennis Macejak, Michel Gilbert, Warren W Wakarchuk, Akihiro Imamura, Hiromune Ando, Makoto Kiso, Niklas Arnberg, Robert L Garcea, Thomas Peters, Christopher B Buck, Thilo Stehle   +14 more
doaj   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Many locks to one key: N-acetylneuraminic acid binding to proteins

IUCrJ
Sialic acids play crucial roles in cell surface glycans of both eukaryotic and prokaryotic organisms, mediating various biological processes, including cell–cell interactions, development, immune response, oncogenesis and host–pathogen interactions. This
KanagaVijayan Dhanabalan, YiYang Cheng, Trung Thach, Ramaswamy Subramanian   +3 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Schematic of Neu5Ac and GlcNAc catabolic pathways.

, 2018
A) The catabolic pathway of N-acetylneuraminic acid (Neu5Ac, red circle) converges with the catabolic pathway of N-acetylglucosamine (GlcNAc, blue circle) through the production of three common catabolites: N-acetylglucosamine-6-phosphate (GlcNAc-6P ...
Salvador Almagro-Moreno (718320), Geethika Reddi (5563334), Kali Pruss (742791), Kathryn L. Cottingham (2912036), Ronald K. Taylor (718323)   +4 more
core   +1 more source

Assessment of Lectin Staining Biomarkers for GNE Myopathy Gene Therapy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims GNE myopathy (GNEM) is a rare, autosomal recessive disorder caused by mutations in the UDP‐N‐acetylglucosamine (GlcNAc) 2‐epimerase/N‐acetylmannosamine (ManNAc) kinase (GNE) gene, which encodes a required enzyme for sialic acid (SA) biosynthesis.
Kristina M. Sattler, Brian J. Paleo, Mackenzie N. Roth, Kara E. Bradley, Megan N. Winkler, Wakako Yoshioka, Ichizo Nishino, Christoph Lepper, Kelly E. Crowe   +8 more
wiley   +1 more source

Detection and quantification of HRV87 in A549 cells with and without Neu5Ac in vitro [PDF]

, 2021
Forkjølelse er et dagligdags problem som forårsakes av ulike varianter av rhinovirus. Rhinovirus er en av de vanligste årsakene til luftveisinfeksjoner og står for omlag 50 % av tilfellene.
Ørstenvik, Hanne Lillerovde
core  

Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene and frequency of blood types in stray cats of İzmir, Turkey

BMC Genomics, 2021
Background Cytidine monophospho-n-acetylneuraminic acid hydroxylase (CMAH) gene associated with blood groups in cats encodes CMAH enzyme that converts Neu5Ac to Neu5Gc.
Hüseyin Can, Sedef Erkunt Alak, Ahmet Efe Köseoğlu, Umut Şahar, Berna Bostanbaş, Serdar Baydarlı, Mert Döşkaya, Cemal Ün   +7 more
doaj   +1 more source

Ingenious Action of Vibrio cholerae Neuraminidase Recruiting Additional GM1 Cholera Toxin Receptors for Primary Human Colon Epithelial Cells

Microorganisms, 2022
For five decades it has been known that the pentamer of B subunits (choleragenoid) of the cholera toxin (CT) of Vibrio cholerae binds with high preference to the ganglioside GM1 (II3Neu5Ac-Gg4Cer).
Johanna Detzner, Charlotte Püttmann, Gottfried Pohlentz, Johannes Müthing   +3 more
doaj   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source