Results 41 to 50 of about 1,943 (161)

TSPyV VP1 specifically binds to terminal Neu5Ac.

, 2015
(A) Crystal structure of the unassembled TSPyV VP1 pentamer in complex with the GM1 glycan. The TSPyV VP1 pentamer is shown in cartoon representation with one monomer depicted in purple. Glycan residues are shown in stick representations and glycan atoms
Bärbel S. Blaum (114952), Mariet C. W. Feltkamp (244842), Luisa J. Ströh (469044), Walter J. Atwood (469045), Aisling S. Dugan (603948), Gretchen V. Gee (786526), Thilo Stehle (114963)   +6 more
core   +1 more source

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

Untersuchung von Anti‐Glykan‐Antikörpern und Erforschung ihres medizinischen Potenzials mithilfe synthetischer Glykane

Angewandte Chemie, EarlyView.
Anti‐Glykan‐Antikörper spielen sowohl bei Gesundheit als auch bei Krankheit eine wesentliche Rolle. Der Zugang zu neuartigen Glykanstrukturen ermöglicht Fortschritte bei der Antikörpercharakterisierung für die Entdeckung von Biomarkern, die Antikörperentwicklung und das Impfstoffdesign.
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Unique location of the TSPyV Neu5Ac binding site.

, 2015
The location of the Neu5Ac binding site on TSPyV VP1 is shifted compared to binding sites of polyomaviruses SV40, BKPyV, JCPyV, MCPy, LPyV, HPyV9 and MPyV, which all engage sialylated glycans by employing a Neu5Ac binding site in a conserved location on ...
Bärbel S. Blaum (114952), Mariet C. W. Feltkamp (244842), Luisa J. Ströh (469044), Walter J. Atwood (469045), Aisling S. Dugan (603948), Gretchen V. Gee (786526), Thilo Stehle (114963)   +6 more
core   +1 more source

An easy, rapid, and sensitive method for detection of drug-resistant influenza virus by using a sialidase fluorescent imaging probe, BTP3-Neu5Ac [PDF]

, 2018
Immunochromatographic kits and RT-PCR are widely used as diagnostic tools for influenza detection in clinical and hygiene fields. Immunochromatographic kits are useful for differential typing of influenza A and influenza B but cannot show if the detected
Yuuki Kurebayashi (235568), Yuuki Kurebayashi, Mika Yamazaki (5509436), Chihiro Tamoto (3167004), Tadanobu Takahashi (235567), Tadamune Otsubo (508346), Chihiro Tamoto, Takashi Suzuki, Kiyoshi Ikeda, Takashi Suzuki (8491), Akira Minami (474027), Tadanobu Takahashi, Tadamune Otsubo, Daisuke Kato, Kiyoshi Ikeda (508348), Daisuke Kato (1827106), Akira Minami, Hitomi Otake (5509439), Mika Yamazaki, Hitomi Otake   +19 more
core   +1 more source

The Urinary Bladder is Rich in Glycosphingolipids Composed of Phytoceramides

Journal of Lipid Research, 2022
Glycosphingolipids (GSLs) are composed of a polar glycan chain and a hydrophobic tail known as ceramide. Together with variation in the glycan chain, ceramides exhibit tissue-specific structural variation in the long-chain base (LCB) and N-acyl chain ...
Takashi Watanabe, Akemi Suzuki, Shin Ohira, Shinji Go, Yuta Ishizuka, Takuya Moriya, Yoshiyuki Miyaji, Tota Nakatsuka, Keita Hirata, Atsushi Nagai, Junko Matsuda   +10 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Inhibition effect of oseltamivir for sialidase activities of oseltamivir-resistant and -sensitive viruses using 4MU-Neu5Ac or BTP3-Neu5Ac.

, 2016
Sialidase activities of oseltamivir-resistant 738 (red circle) and -sensitive 838 (blue square) were measured in the presence of ten-fold serial dilutions of oseltamivir by using BTP3-Neu5Ac (A) or 4MU-Neu5Ac (B).
Yuuki Kurebayashi (235568), Keiji Sahara (3167001), Kiyoshi Ikeda (508348), Chihiro Tamoto (3167004), Tadanobu Takahashi (235567), Tadamune Otsubo (508346), Nona Shibahara (832839), Hirohisa Wada (832844), Takashi Suzuki (8491), Tatsuya Yokozawa (3167007), Akira Minami (474027)   +10 more
core   +1 more source

Elucidation of the Binding Orientation in α2,3- and α2,6-Linked Neu5Ac-Gal Epitopes toward a Hydrophilic Molecularly Imprinted Monolith.

, 2023
N-Acetylneuraminic acid and its α2,3/α2,6-glycosidic linkages with galactose (Neu5Ac-Gal) are major carbohydrate antigen epitopes expressed in various pathological processes, such as cancer, influenza, and SARS-CoV-2.
Sparrman, Tobias, Mavliutova, Liliia,, Irgum, Knut,, Huynh, Chau Minh, Sellergren, Börje,, Mavliutova, Liliia, Sellergren, Börje, Irgum, Knut, Huynh, Chau Minh,, Sparrman, Tobias,   +9 more
core   +2 more sources

Development of mumps virus-specific sialidase imaging probes through chemical modifications of sialic acid

Scientific Reports
Some viruses, such as mumps virus (MuV), possess sialidases that cleave terminal sialic acids, primarily N-acetylneuraminic acid (Neu5Ac), from glycans.
Yutaka Narimichi, Tadanobu Takahashi, Yuuki Kurebayashi, Tadamune Otsubo, Kiyoshi Ikeda, Yu Saito, Akira Minami, Hideyuki Takeuchi   +7 more
doaj   +1 more source