Results 31 to 40 of about 1,943 (161)
mBio, 2019 Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative bacterial pathogen that is adapted exclusively to human hosts. NTHi utilizes sialic acid from the host as a carbon source and as a terminal sugar on the outer membrane glycolipid ...
Preston S. K. Ng +10 more
doaj +1 more source
Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides
Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok +4 more
wiley +2 more sources
N-Acetylneuraminic acid attenuates hypercoagulation on high fat diet-induced hyperlipidemic rats
Food & Nutrition Research, 2015 Background and objective: N-Acetylneuraminic acid (Neu5Ac), a type of sialic acid, has close links with cholesterol metabolism and is often used as a biomarker in evaluating the risk of cardiovascular diseases.
Zhang Yida +6 more
doaj +1 more source
Visualization of sialidase activity in Mammalian tissues and cancer detection with a novel fluorescent sialidase substrate. [PDF]
PLoS ONE, 2014 Sialidase removes sialic acid from sialoglycoconjugates and plays crucial roles in many physiological and pathological processes. Various human cancers express an abnormally high level of the plasma membrane-associated sialidase isoform.Visualization of ...
Akira Minami +13 more
doaj +1 more source
HPLC-based Neu5Ac quantification.
, 2018 A) standard Neu5Ac calibration curve, B) Dot plot showing Neu5Ac expression levels derived and quantified from human serum N-glycans of four ethnic groups.
Hiroshi Hinou (1466248) +7 more
core +1 more source
Hydrolysis of BTP-Neu5Ac with bacterial sialidase.
, 2014 A–D, Relative fluorescence intensities proportionally increased with increasing amounts of AUSA in 10 µM BTP2-Neu5Ac (A), BTP3-Neu5Ac (B) and BTP4-Neu5Ac (C) but not in 10 µM Res-Neu5Ac (D). Each bar and line represent the mean ± S.E.M. (n = 3).
Tsunehiro Yokochi (508351) +13 more
core +1 more source
E-Journal of Chemistry, 2007 A molecular imprinting technique was applied in this work to detect N-acetylneuraminic acid (Neu5Ac) and its analogue structure. Twomolecularly imprinted polymers (MIP) were prepared using Neu 5Ac as the template molecule, as well as methacrylic acid ...
Hsin-Hung Pan +3 more
doaj +1 more source
A Water Soluble Pd2L4 Cage for Selective Binding of Neu5Ac
Chemistry – A European Journal, 2021 AbstractThe sialic acid N‐acetylneuraminic acid (Neu5Ac) and its derivatives are involved in many biological processes including cell‐cell recognition and infection by influenza. Molecules that can recognize Neu5Ac might thus be exploited to intervene in or monitor such events.
Xander Schaapkens +4 more
openaire +4 more sources
Mass spectrum of purified Neu5Ac-α2,3-lactulose and Neu5Ac-α2,6-lactulose.
, 2018 Mass spectrum of purified Neu5Ac-α2,3-lactulose and Neu5Ac-α2,6-lactulose.
Ruiyao Zhang (5429897) +9 more
core +1 more source
Multistep metabolic engineering of Pichia pastoris for biosynthesis of N‑acetylneuraminic acid
Applied Microbiology and BiotechnologyFree or protein-conjugated N-Acetylneuraminic acid (Neu5Ac) is widely distributed in organisms and possesses diverse biological functions, and for example lactoferrin with Neu5Ac-mediated sialylation exhibits significantly enhanced functional activity ...
Xiaomin Zhao +7 more
doaj +1 more source