Results 11 to 20 of about 1,943 (161)

Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac [PDF]

Marine Drugs, 2003
: CMP-Neu5Ac is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates. In this paper, a large-scale production system of CMP-Neu5Ac by a single strain is reported. The co-expression of Neu5Ac aldolase (EC4.1.3.3) and CMP-Neu5Ac
Min Xiao, Peng George Wang, Jing Song, Hesheng Zhang, Bingyuan Wu, Yingxin Zhang, Hanfen Li   +6 more
doaj   +3 more sources

Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

eLife
N -Acetylneuraminic acid (Neu5Ac) is a negatively charged nine-carbon amino sugar that is often the peripheral sugar in human cell-surface glycoconjugates.
Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy   +7 more
doaj   +6 more sources

Elevated concentrations of Neu5Ac and Neu5,9Ac2 in human plasma: potential biomarkers of cardiovascular disease [PDF]

Glycoconjugate Journal, 2023
AbstractCardiovascular disease (CVD) is a group of health conditions affecting the heart and vascular system with very high prevalence and mortality rates. The presence of CVD is characterised by high levels of inflammation which have previously been associated with increased plasma concentrations of N-acetyl neuraminic acid (Neu5Ac).
Cheeseman, Jack, Badia, Concepcion, Elgood-Hunt, Georgia, Gardner, Richard A., Trinh, Duong N., Monopoli, Marco P., Kuhnle, Gunter, Spencer, Daniel I.R., Osborn, Helen M.I.   +8 more
openaire   +3 more sources

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]

Nature Communications, 2014
AbstractMammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH).
Ng, Preston S. K., Boehm, Raphael, Hartley-Tassell, Lauren E., Steen, Jason A., Wang, Hui, Lukowski, Samuel W., Hawthorne, Paula L., Trezise, Ann E. O., Coloe, Peter J., Grimmond, Sean M., Haselhorst, Thomas, von Itzstein, Mark, Paton, Adrienne W., Paton, James C., Jennings, Michael P.   +14 more
core   +13 more sources

Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2020
To explore the repertoire of glycan-specific immunoglobulin G (IgG) antibodies in treatment-naive patients with relapsing-remitting multiple sclerosis (RRMS).A systems-level approach combined with glycan array technologies was used to determine specificities and binding reactivities of glycan-specific IgGs in treatment-naive patients with RRMS compared
Kayluz F. Boligan, Johanna Oechtering, Christian W. Keller, Benjamin Peschke, Robert Rieben, Nicolai Bovin, Ludwig Kappos, Richard D. Cummings, Jens Kuhle, Stephan von Gunten, Jan D. Lünemann   +10 more
openaire   +6 more sources

Neu5Ac Induces Human Dental Pulp Stem Cell Osteo-/Odontoblastic Differentiation by Enhancing MAPK/ERK Pathway Activation

Stem Cells International, 2021
Dental pulp stem cells (DPSCs) must undergo odontoblastic differentiation in order to facilitate the process of dentin-pulp complex repair. Herein, we sought to explore the ability of Neu5Ac (one form of sialic acid) to influence DPSC osteo ...
Changzhou Li, Xinghuan Xie, Zhongjun Liu, Jianhua Yang, Daming Zuo, Shuaimei Xu   +5 more
doaj   +2 more sources

Mechanistic study of CMP‐Neu5Ac hydrolysis by α2,3‐sialyltransferase from Pasteurella dagmatis [PDF]

FEBS Letters, 2014
Bacterial sialyltransferases of the glycosyltransferase family GT‐80 exhibit pronounced hydrolase activity toward CMP‐activated sialyl donor substrates. Using in situ proton NMR, we show that hydrolysis of CMP‐Neu5Ac by Pasteurella dagmatis α2,3‐sialyltransferase (PdST) occurs with axial‐to‐equatorial inversion of the configuration at the anomeric ...
Schmölzer, Katharina, Luley-Goedl, Christiane, Czabany, Tibor, Ribitsch, Doris, Schwab, Helmut, Weber, Hansjörg, Nidetzky, Bernd   +6 more
openaire   +4 more sources

Theoretical Studies on the Electronic Structure Parameters and Reactive Activity of Neu5Gc and Neu5Ac under Food Processing Solvent Environment

Molecules, 2019
The animal product hazard factor N-glycolylneuraminic (Neu5Gc) and brain nutrient substance N-acetylneuraminic acid (Neu5Ac) were studied at the M062X/6-311 + G(d,p) geometry optimization level.
Rui Chang, Bowen Yang, Qiu-Jin Zhu
doaj   +2 more sources

Synthesis of Neu5Ac-Gal-functionalized gold glyconanoparticles [PDF]

Carbohydrate Research, 2009
Neu5Ac-Gal-containing neoglycoside 1 was convergently synthesized through Cu(I)-catalyzed 1,3-dipolar cycloaddition of methyl (6-azidohexyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-O-alpha-d-glycero-d-galacto-2-nonulopyranosyl)uronate and 11-thioacetylundecyl 2,4,6-tri-O-benzoyl-3-O-propargyl-beta-d-galactopyranoside.
Lei, Zhang, Guohua, Wei, Yuguo, Du
openaire   +2 more sources

Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated with Human-Like Neu5Gc loss [PDF]

, 2021
OBJECTIVE: Species-specific pseudogenization of the CMAH gene during human evolution eliminated common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) biosynthesis from its precursor, N-acetylneuraminic acid (Neu5Ac).
Gordts, Philip LSM, Zengler, Karsten, Kawanishi, Kunio, Coker, Joanna K, Grunddal, Kaare V., Varki, Ajit, Hsiao, Jason, Gordts, Philip L.S.M., Grunddal, Kaare V, Varki, Nissi, Dhar, Chirag   +10 more
core   +1 more source