Results 81 to 90 of about 1,943 (161)
Proteoglycan Research, Volume 4, Issue 3, July 2026.ABSTRACT The Ehlers–Danlos syndromes (EDS) are a group of heritable connective tissue disorders, characterized by varying degrees of joint hypermobility, skin hyperextensibility and extracellular matrix defects. Spondylodysplastic type of EDS (spEDS) is a rare type of this group that can be caused by pathogenic variants in the B3GALT6 gene, coding for ...
Noborn Fredrik +6 more
wiley +1 more source
Small, Volume 22, Issue 39, 13 July 2026.Saccharide‐appended cyclic dipeptides are designed and developed as building blocks for glycosidase‐responsive supramolecular hydrogels. Their aqueous self‐assembly enables β‐galactosidase‐triggered gel‐to‐sol and neuraminidase‐triggered sol‐to‐gel transition systems, highlighting their potential as glycosidase‐responsive soft materials for biomedical ...
Shintaro Sugiura +6 more
wiley +1 more source
Fluorescent visualization of mumps virus-infected cells with BTP3-Neu5Ac.
, 2015 (A) Fluorescent visualization of mumps virus-infected cells. Vero cells were inoculated with mumps virus and then incubated at 37°C for 48 hr. The infected cells were stained with 10 μM BTP3-Neu5Ac at 37°C for 15 min in the absence (left panel) or ...
Yuuki Kurebayashi (235568) +13 more
core +1 more source
CosmeticsBackground: N-Acetylneuraminic acid (Neu5Ac), the predominant form of sialic acid, exhibits potent antioxidant, anti-inflammatory, and anti-glycation properties in preclinical studies, suggesting potential dermatological benefits.
Zicun Lin +7 more
doaj +1 more source
Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems
Advanced Science, Volume 13, Issue 31, 4 June 2026.A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller +9 more
wiley +1 more source
Porcine kidney xenotransplantation: From primate models to clinical reality
Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1142-1166, June 2026.In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo +3 more
wiley +1 more source
Presence of N-acetylneuraminic acid in the lung during postnatal development
European Journal of Histochemistry, 2020 Sialic acids, particularly N-acetylneuraminic acid (Neu5Ac), are present as terminal components of rich and complex oligosaccharide chains, which are termed glycans, and are exhibited on the cell surfaces, especially on epithelial cells.
Maria de Fátima Martins +3 more
doaj +1 more source
Why Do Humans Exercise? A Neuro‐Evolutionary Framework for Discretionary Physical Effort
Evolutionary Anthropology: Issues, News, and Reviews, Volume 35, Issue 2, June 2026.ABSTRACT Hominin evolution made physical activity obligatory for survival. Modern environments decoupled effort from ecological returns, generating an evolutionary mismatch that favors energy conservation over voluntary movement. This review distinguishes between subsistence‐based physical activity, the ancestral condition directly coupled to survival,
Miguel Ángel Rodríguez +4 more
wiley +1 more source
Reduced PNA-positive glomeruli ratios in Neu5Ac-treated mt mice.
, 2012 (A) Kidneys double-stained for PC and PNA, from untreated ht (upper panels) and mt (middle panels) mice, and Neu5Ac-treated mt mice (bottom panels). Sections were stained with an anti-PC antibody (left panels; red), PNA (middle panels; green), and both ...
Tomoya Asaka (187958) +7 more
core +1 more source
Pharmacological ResearchMucin is known to modulate the gut environment; however, its specific mechanisms and downstream metabolites in alleviating obesity and hepatic steatosis remain unclear.
Shaohui You +11 more
doaj +1 more source