Results 101 to 110 of about 3,941,026 (357)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Learning long-range spatial dependencies with horizontal gated-recurrent units

, 2018
Progress in deep learning has spawned great successes in many engineering applications. As a prime example, convolutional neural networks, a type of feedforward neural networks, are now approaching -- and sometimes even surpassing -- human accuracy on a ...
Kim, Junkyung, Linsley, Drew, Serre, Thomas, Veerabadran, Vijay   +3 more
core   +1 more source

Gain control network conditions in early sensory coding [PDF]

, 2013
Gain control is essential for the proper function of any sensory system. However, the precise mechanisms for achieving effective gain control in the brain are unknown.
A Couto, A Destexhe, AF Silbering, AF Silbering, B Haider, Brian H. Smith, BW Strowbridge, C Buckley, CC Girardin, CI Bargmann, CJP Vicente, CM Root, Cv Vreeswijk, D Dominguez, DA McCormick, E Av-Ron, E Salinas, EA Hallem, EA Hallem, Eduardo Serrano, F Locatelli, GA Wright, GC Turner, H Belmabrouk, H Breer, HR Wilson, I Ito, IP Sudhakaran, J Huang, J Perez-Orive, JJ Hopfield, K Touhara, LF Abbott, M Bazhenov, M García-Sanchez, M Ng, M Papadopoulou, M Rabinovich, M Schmuker, M Stopfer, M Yokoi, N Yamagata, O Shriki, Olaf Sporns, P Anderson, P Szyszka, R Huerta, R Huerta, R Huerta, Rafael Levi, Ramón Huerta, RI Wilson, RI Wilson, S Das, S Grossberg, S Krofczik, S Sachse, Si Amari, SR Olsen, SR Olsen, SR Olsen, T Nowotny, TA Cleland, TA Cleland, Thomas Nowotny, TP Vogels, V Bhandawat, Y Shang   +67 more
core   +5 more sources

Neural induction - Dual SMAD inhibition

StemBook, 2014
Dual SMAD inhibition takes a confluent, feeder free culture of hPSCs and rapidly differentiates them into early neurectoderm (Chambers et al., 2009). This rapid differentiation is caused by blocking the two signaling pathways that utilize SMADs for transduction: BMP and TGFB.
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Neural reactivations during sleep determine network credit assignment. [PDF]

, 2017
A fundamental goal of motor learning is to establish the neural patterns that produce a desired behavioral outcome. It remains unclear how and when the nervous system solves this 'credit assignment' problem.
Bodepudi, Anitha, Ganguly, Karunesh, Gulati, Tanuj, Guo, Ling, Ramanathan, Dhakshin S   +4 more
core   +3 more sources

Critical excitation-inhibition balance in dense neural networks [PDF]

Physical Review E, 2019
The "edge of chaos" phase transition in artificial neural networks is of renewed interest in light of recent evidence for criticality in brain dynamics. Statistical mechanics traditionally studied this transition with connectivity $k$ as the control parameter and an exactly balanced excitation-inhibition ratio.
Baumgarten, Lorenz, Bornholdt, Stefan
openaire   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Anxiety-Like Behavioural Inhibition Is Normative under Environmental Threat-Reward Correlations.

PLoS Computational Biology, 2015
Behavioural inhibition is a key anxiety-like behaviour in rodents and humans, distinct from avoidance of danger, and reduced by anxiolytic drugs. In some situations, it is not clear how behavioural inhibition minimises harm or maximises benefit for the ...
Dominik R Bach
doaj   +1 more source