Results 71 to 80 of about 3,455,773 (294)

Metabolic Brain Network Reorganization in Temporal Lobe Epilepsy With Aware or Impaired Awareness Seizures

Journal of Integrative Neuroscience
Background: Temporal lobe epilepsy (TLE) is increasingly recognized as a dysfunction of the brain network. However, the topological alterations of the metabolic brain network underlying impaired awareness seizures (IAS) remain unclear.
Jingke Xiao, Fan Yang, Hanlin Zhang, Jiangyan Liu   +3 more
doaj   +1 more source

Robust Local Cluster Neural Networks (ESANN) [PDF]

, 2006
Eickhoff R, Sitte J, Rückert U. Robust Local Cluster Neural Networks (ESANN). In: Proceedings of the 14th European Symposium on Artificial Neural Networks (ESANN).
Eickhoff, Ralf, Rueckert, Ulrich, Sitte, Joaquin, Rückert, Ulrich   +3 more
core  

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

FRACTIONAL ANISOTROPY IN DEGENERATIVE CERVICAL STENOSIS SURGERY PROGNOSTIC: A SYSTEMATIC REVIEW [PDF]

Coluna/Columna
Cervical spondylotic myelopathy (CSM) is a common disease with an increased anticipated burden to health systems worldwide. Methods to predict outcomes in these patients are needed so physicians can provide more effective care. Fractional anisotropy (FA)
Leon Cleres Penido Pinheiro, Rodrigo Almeida Cunha, Eloy Rusafa Neto, Roger Schmidt Brock   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Impaired neural conduction in crossed visual pathways in patients with ocular hypertension

, 2004
To evaluate the neural conduction along crossed and uncrossed visual pathways in patients with ocular hypertension (OHT)
Coppola, G, Oddone, F, Bucci, MG, Parisi, V, Olzi, D, MANNI, GIANLUCA   +5 more
core   +2 more sources

Mimicking natural neural encoding through retinal electrostimulation

, 2017
Retinal neuroprostheses or `bionic eyes', aim to restore patterned vision to those with vision loss by electrically stimulating the remaining neurons in the degenerate retina.
Dokos, Socrates, John W. Morley, Gregg J. Suaning, David Tsai, Suaning, Gregg J., Barriga-Rivera, Alejandro, Tsai, David, Nigel H. Lovell, Morley, John W. (R12018), Tianruo Guo, Socrates Dokos, Guo, Tianruo, Lovell, Nigel H., Alejandro Barriga-Rivera   +13 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source