Results 51 to 60 of about 2,988,540 (294)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The role of axon guidance molecules in the pathogenesis of epilepsy

Neural Regeneration Research
Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms
Zheng Liu, Chunhua Pan, Hao Huang
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function [PDF]

, 2013
Zebrafish have great potential to contribute to our understanding of behavioural genetics and thus to contribute to our understanding of the aetiology of psychiatric disease.
Brock, AJ, Walton, Robert T., Walton, RT, Caroline Helen Brennan, Robert T. Walton, Matthew O Parker, Alistair J Brock, Parker, Matthew O., Brennan, Caroline H., Alistair J. Brock, Brennan, CH, Parker, MO, Robert T Walton, Brock, Alistair J., Matthew O. Parker, Caroline H. Brennan   +15 more
core   +1 more source

Multi-omics technologies: Novel tools and methods for assessing nerve injury and regeneration

Neural Regeneration Research
Recently, with the rapid advancement of multi-omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, new tools and approaches have been introduced for studying nerve injury and regeneration.
Qiang Zhou, Zongren Zhao, Da Tan, Chenhao Fang, Zhaoli Shen, Shun Li, Xianzhen Chen   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genetic Signatures of Competitive Performance in Burmese Gamecocks: A Transcriptomic Analysis

Biology
Understanding the genetic basis of high-performance animals is vital for biological insight and breeding. This study aimed to identify genetic factors distinguishing champion gamecocks (Gallus gallus domesticus) from less successful ones, representing ...
Supawadee Piratae, Chanistha Yamtubtim, Thanitaporn Nonsri, Panpanit Poomprasert, Tarid Purisotayo   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Language outcomes and neural pathways.

, 2022
Language outcomes and neural pathways.
Olga Tymofiyeva (333740), Duan Xu (333745), Shabnam Peyvandi (11909666), Stephany Cox (11909669), Alice Ramirez (11909663), Dawn Gano (11909672), Patrick S. McQuillen (10775351)   +6 more
core   +1 more source