Results 51 to 60 of about 2,622,049 (363)

Mechanism of Neural Regeneration Induced by Natural Product LY01 in the 5×FAD Mouse Model of Alzheimer’s Disease

Frontiers in Pharmacology, 2022
Background: A sharp decline in neural regeneration in patients with Alzheimer’s disease (AD) exacerbates the decline of cognition and memory. It is of great significance to screen for innovative drugs that promote endogenous neural regeneration. Cytisine
Xiao-wan Li, Yangming Lu, Shu-Yao Zhang, Ning-Ning Sai, Yunyi Fan, Yong Cheng, Qingshan Liu   +6 more
semanticscholar   +1 more source

The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway

Cell Reports, 2019
Summary: Under food deprivation conditions, Drosophila larvae exhibit increases in locomotor speed and synaptic bouton numbers at neuromuscular junctions (NMJs).
Keisuke Kamimura, Aiko Odajima, Yuko Ikegawa, Chikako Maru, Nobuaki Maeda   +4 more
doaj   +1 more source

Neural regeneration in the human central nervous system-from understanding the underlying mechanisms to developing treatments. Where do we stand today? [PDF]

Front Neurol
Kvistad CE, Kråkenes T, Gavasso S, Bø L.   +3 more
europepmc   +3 more sources

Enhanced derivation of human pluripotent stem cell-derived cortical glutamatergic neurons by a small molecule

Scientific Reports, 2017
Human pluripotent stem cells (hPSCs) play important role in studying the function of human glutamatergic neurons and related disease pathogenesis. However, the current hPSC-derived cortical system produced a significant number of inhibitory GABAergic ...
Shi-Ying Cao, Yao Hu, Cheng Chen, Fang Yuan, Min Xu, Qi Li, Kai-Heng Fang, Yaoyu Chen, Yan Liu   +8 more
doaj   +1 more source

Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation. [PDF]

, 2016
After an initial period of recovery, human neurological injury has long been thought to be static. In order to improve quality of life for those suffering from stroke, spinal cord injury, or traumatic brain injury, researchers have been working to ...
Edgerton, V Reggie, Krucoff, Max O, Rahimpour, Shervin, Slutzky, Marc W, Turner, Dennis A   +4 more
core   +1 more source

SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling

Theranostics, 2021
Axonal degeneration is a common pathological feature in many acute and chronic neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif-containing 1), the fifth TLR (Toll-like receptor) adaptor, has diverse functions in ...
Huitao Liu, Jingjing Zhang, Xingxing Xu, Sheng Lu, Danlu Yang, Changnan Xie, Mengxian Jia, Wenbin Zhang, Lingting Jin, Xiwu Wang, Xiya Shen, Fayi Li, Wangfei Wang, Xiao-mei Bao, Sijia Li, Minyu Zhu, W. Wang, Ying Wang, Zhihui Huang, Honglin Teng   +19 more
semanticscholar   +1 more source

The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies [PDF]

, 2017
The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems.
Barton, Matthew J., Clarke, Mary, Ekberg, Jenny, St. John, James, Wright, Alison   +4 more
core   +2 more sources

Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish

Mediators of Inflammation, 2019
As adult mammals lack the capacity to replace or repair damaged neurons, degeneration and trauma (and subsequent dysfunction) of the central nervous system (CNS) seriously constrains the patient’s life quality.
Ilse Bollaerts, Jessie Van houcke, An Beckers, Kim Lemmens, Sophie Vanhunsel, Lies De Groef, Lieve Moons   +6 more
doaj   +1 more source

Metabotropic Glutamate Receptors 1 Regulates Rat Carotid Body Response to Acute Hypoxia via Presynaptic Mechanism

Frontiers in Neuroscience, 2021
Background: The carotid body (CB) plays a critical role in oxygen sensing; however, the role of glutamatergic signaling in the CB response to hypoxia remains uncertain.
Chaohong Li, Baosheng Zhao, Chenlu Zhao, Lu Huang, Yuzhen Liu   +4 more
doaj   +1 more source

Neurotrophic factors and corneal nerve regeneration [PDF]

, 2017
The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination.
Lambiase, Alessandro, Sacchetti, Marta
core   +2 more sources