Results 31 to 40 of about 1,045,843 (356)

Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice

Molecular Brain, 2020
Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network.
Sarivin Vanan, Xiaoxia Zeng, Sook Yoong Chia, Katarina Varnäs, Mei Jiang, Ke Zhang, Wuan Ting Saw, Parasuraman Padmanabhan, Wei-Ping Yu, Zhi-Dong Zhou, Christer Halldin, Balázs Gulyás, Eng-King Tan, Li Zeng   +13 more
doaj   +1 more source

Neural stem cell transplantation therapy for brain ischemic stroke: Review and perspectives

World Journal of Stem Cells, 2019
Brain ischemic stroke is one of the most common causes of death and disability, currently has no efficient therapeutic strategy in clinic. Due to irreversible functional neurons loss and neural tissue injury, stem cell transplantation may be the most ...
Guilong Zhang, Zhijun Zhu, Ye-Zhong Wang
semanticscholar   +1 more source

Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease

Scientific Reports, 2018
Stem cell transplantation offers a potentially transformative approach to treating neurodegenerative disorders. The safety of cellular therapies is established in multiple clinical trials, including our own in amyotrophic lateral sclerosis.
Lisa M. McGinley, Osama N. Kashlan, Elizabeth S. Bruno, Kevin S Chen, J. Hayes, Samy R. Kashlan, J. Raykin, K. Johe, G. Murphy, E. Feldman   +9 more
semanticscholar   +1 more source

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

Nature Neuroscience, 2018
Ectopic expression of defined transcription factors can force direct cell-fate conversion from one lineage to another in the absence of cell division. Several transcription factor cocktails have enabled successful reprogramming of various somatic cell ...
Marisa Karow, Marisa Karow, J. G. Camp, S. Falk, Tobias Gerber, Abhijeet Pataskar, Malgorzata Gac-Santel, J. Kageyama, Agnieska Brazovskaja, A. Garding, Wenqiang Fan, T. Riedemann, Antonella Casamassa, Antonella Casamassa, Andrej Smiyakin, C. Schichor, M. Götz, V. Tiwari, Barbara Treutlein, Barbara Treutlein, B. Berninger   +20 more
semanticscholar   +1 more source

Neural stemness contributes to cell tumorigenicity [PDF]

Cell & Bioscience, 2020
Abstract Background Previous studies demonstrated the dependence of cancer on nerve. Recently, a growing number of studies reveal that cancer cells share the property and regulatory network with neural stem/progenitor cells. However, relationship between the property of neural stemness and cell tumorigenicity is unknown.
Liyang Xu, Min Zhang, Lihua Shi, Xiaoli Yang, Lu Chen, Ning Cao, Anhua Lei, Ying Cao   +7 more
openaire   +4 more sources

Human RPE Stem Cells Grown into Polarized RPE Monolayers on a Polyester Matrix Are Maintained after Grafting into Rabbit Subretinal Space

Stem Cell Reports, 2014
Transplantation of the retinal pigment epithelium (RPE) is being developed as a cell-replacement therapy for age-related macular degeneration. Human embryonic stem cell (hESC) and induced pluripotent stem cell (iPSC)-derived RPE are currently translating
Boris V. Stanzel, Zengping Liu, Sudawadee Somboonthanakij, Warapat Wongsawad, Ralf Brinken, Nicole Eter, Barbara Corneo, Frank G. Holz, Sally Temple, Jeffrey H. Stern, Timothy A. Blenkinsop   +10 more
doaj   +1 more source

Neural stem cell therapy for subacute and chronic ischemic stroke

Stem cell research & therapeutics, 2018
Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading cause of death and disability.
A. Boese, Q. Le, D. Pham, M. Hamblin, Jean-Pyo Lee   +4 more
semanticscholar   +1 more source

Therapeutic Plasticity of Neural Stem Cells [PDF]

Frontiers in Neurology, 2020
Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes inside and outside of the nervous system, with a capacity of almost unlimited self-renewal, of releasing trophic and immunomodulatory factors, and of exploiting ...
Linda Ottoboni, Beatrice von Wunster, Gianvito Martino, Gianvito Martino   +3 more
openaire   +5 more sources

Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease

Stem Cell Research & Therapy, 2020
Background Significant developments in stem cell therapy for Parkinson’s disease (PD) have already been achieved; however, methods for reliable assessment of dopamine neuron maturation in vivo are lacking.
Julian L. Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V. Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W. L. Lee, Zhiwei Zhang, Pragalath Sadasivam, Eng King Tan, Sajinder K. Luthra, William D. Shingleton, Steve K. W. Oh, Li Zeng, Edward G. Robins   +23 more
doaj   +1 more source

Clinical applications of stem cell-derived exosomes

Signal Transduction and Targeted Therapy
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation.
Fei Tan, Xuran Li, Zhao Wang, Jiaojiao Li, K. Shahzad, Jialin C. Zheng   +5 more
semanticscholar   +1 more source