Results 31 to 40 of about 1,438,323 (398)
Modeling adult skeletal stem cell response to laser-machined topographies through deep learning [PDF]
Tissue and Cell: Volume 67, December 2020, 101442, 2020 The response of adult human bone marrow stromal stem cells to surface topographies generated through femtosecond laser machining can be predicted by a deep neural network. The network is capable of predicting cell response to a statistically significant level, including positioning predictions with a probability P < 0.001, and therefore can be used as ...
arxiv +1 more source
Effect of Bmi1 over-expression on gene expression in adult and embryonic murine neural stem cells
Scientific Reports, 2018 The ability of isolated neural stem cells (NSCs) to proliferate as neurospheres is indicative of their competence as stem cells, and depends critically on the polycomb group (PcG) member Bmi1: knockdown of Bmi1 results in defective proliferation and self-
Mythily Ganapathi +6 more
doaj +1 more source
Neural Stem Cells and Glioblastoma [PDF]
The Neuroradiology Journal, 2014 Glioblastoma multiforme represents one of the most common brain cancers with a rather heterogeneous cellular composition, as indicated by the term “multiforme“. Recent reports have described the isolation and identification of cancer neural stem cells from human adult glioblastoma multiforme, which possess the capacity to establish, sustain, and ...
Rossella Rispoli +4 more
openaire +3 more sources
Nature Neuroscience, 2018 Internal N6-methyladenosine (m6A) modification is widespread in messenger RNAs (mRNAs) and is catalyzed by heterodimers of methyltransferase-like protein 3 (Mettl3) and Mettl14.
Yang Wang +10 more
semanticscholar +1 more source
Scientific Reports, 2017 Human pluripotent stem cells (hPSCs) play important role in studying the function of human glutamatergic neurons and related disease pathogenesis. However, the current hPSC-derived cortical system produced a significant number of inhibitory GABAergic ...
Shi-Ying Cao +8 more
doaj +1 more source
Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]
, 2018 Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita +6 more
core +3 more sources
Journal of Clinical Oncology, 2014 PURPOSE Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid conformally the hippocampal neural stem-cell compartment during WBRT (HA-WBRT ...
V. Gondi +16 more
semanticscholar +1 more source
Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice
Molecular Brain, 2020 Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network.
Sarivin Vanan +13 more
doaj +1 more source
Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential mechanism [PDF]
Seminars in Cancer Biology 30 (2015) 42-51, 2013 Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend of malignant transformation can be described as a two-phase process, where an initial increase of network plasticity is followed by a decrease of plasticity at late stages of tumor development. The fluctuating intensity of stress factors, like hypoxia, inflammation
arxiv +1 more source
Mechanically-driven Stem Cell Separation in Tissues caused by Proliferating Daughter Cells [PDF]
SciPost Phys. 16, 097 (2024), 2023 The homeostasis of epithelial tissue relies on a balance between the self-renewal of stem cell populations, cellular differentiation, and loss. Although this balance needs to be tightly regulated to avoid pathologies, such as tumor growth, the regulatory mechanisms, both cell-intrinsic and collective, which ensure tissue steady-state are still poorly ...
arxiv +1 more source