Results 61 to 70 of about 448,417 (306)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation

Neurobiology of Disease, 2007
The modification of histone N-terminal tails by acetylation or deacetylation can alter the interaction between histones and DNA, and thus regulate gene expression. Recent experiments have demonstrated that valproic acid (VPA), a well-known anti-epileptic
Dong-In Sinn, Se-Jeong Kim, Kon Chu, Keun-Hwa Jung, Soon-Tae Lee, Eun-Cheol Song, Jeong-Min Kim, Dong-Kyu Park, Sang Kun Lee, Manho Kim, Jae-Kyu Roh   +10 more
doaj   +1 more source

Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome

Frontiers in Cell and Developmental Biology, 2020
Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity.
Soraya Martín-Suárez, Oihane Abiega, Ana Ricobaraza, Rubén Hernandez-Alcoceba, Juan Manuel Encinas, Juan Manuel Encinas, Juan Manuel Encinas   +6 more
doaj   +1 more source

Locally induced neural stem cells/pluripotent stem cells for in vivo cell replacement therapy [PDF]

, 2008
: Neural stem cells hold the key to innovative new treatments for age-associated degeneration and traumatic injury to the brain and spinal cord. We hypothesized that the in vivo induced pluripotent stem cells or neural stem cells through 'forced gene ...
Arias-Carrión, O, Yuan, TF
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway [PDF]

, 2022
Zongkui Wang, Peng Jiang, Fengjuan Liu, Xi Du, Li Ma, Shengliang Ye, Haijun Cao, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang, Changqing Li   +11 more
openalex   +1 more source

Інноваційна активність підприємств України: технологічний аспект [PDF]

, 2004
Hazard assessment of chemicals and pharmaceuticals is increasingly gaining from knowledge about molecular mechanisms of toxic action acquired in dedicated in vitro assays.
de Jong, Esther, de Klerk, Arja, de la Fonteyne, Liset J. J., Piersma, Aldert H., Schulpen, Sjors H. W.   +4 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes

Genome Medicine
Background Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and Parkinson’s disease dementia (PDD) collectively represent the majority of dementia cases worldwide.
Sook-Yoong Chia, Mengwei Li, Zhihong Li, Haitao Tu, Jolene Wei Ling Lee, Lifeng Qiu, Jingjing Ling, Richard Reynolds, Salvatore Albani, Eng-King Tan, Adeline Su Lyn Ng, Jinmiao Chen, Li Zeng   +12 more
doaj   +1 more source

Advances in 3D bioprinting for modeling the blood-brain barrier in neurodegenerative diseases

Frontiers in Molecular Biosciences
The growing burden of neurodegenerative diseases (NDD) on healthcare systems, driven by global aging population, has increased interest in modelling the blood-brain barrier (BBB).
Shirleen Tan, Lifeng Qiu, Jolene Wei Ling Lee, Jolene Wei Ling Lee, Li Zeng, Li Zeng, Li Zeng   +6 more
doaj   +1 more source