Results 61 to 70 of about 1,438,323 (398)
The impact of species and cell type on the nanosafety profile of iron oxide nanoparticles in neural cells [PDF]
, 2016 Background: While nanotechnology is advancing rapidly, nanosafety tends to lag behind since general mechanistic insights into cell-nanoparticle (NP) interactions remain rare.
De Smedt, Stefaan +7 more
core +1 more source
Therapeutic Plasticity of Neural Stem Cells [PDF]
Frontiers in Neurology, 2020 Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes inside and outside of the nervous system, with a capacity of almost unlimited self-renewal, of releasing trophic and immunomodulatory factors, and of exploiting ...
Linda Ottoboni +3 more
openaire +5 more sources
Exogenous neural stem cell transplantation for cerebral ischemia
Neural Regeneration Research, 2019 Cerebral ischemic injury is the main manifestation of stroke, and its incidence in stroke patients is 70–80%. Although ischemic stroke can be treated with tissue-type plasminogen activator, its time window of effectiveness is narrow.
Ling-Yi Liao +3 more
semanticscholar +1 more source
Lessons Learned from Pioneering Neural Stem Cell Studies
Stem Cell Reports, 2017 As stem cell products are increasingly entering early stage clinical trials, we are learning from experience about how cell products may be best assessed for safety and efficacy.
Sally Temple, Lorenz Studer
doaj +1 more source
Human organoids in basic research and clinical applications
Signal Transduction and Targeted Therapy, 2022 Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from healthy individuals or patients that recapitulate the cellular heterogeneity ...
Xiao-Yan Tang +9 more
doaj +1 more source
Cell reprogramming modelled as transitions in a hierarchy of cell cycles [PDF]
J. Phys. A: Math. Theor. 50 (2017) 425601 (23pp), 2016 We construct a model of cell reprogramming (the conversion of fully differentiated cells to a state of pluripotency, known as induced pluripotent stem cells, or iPSCs) which builds on key elements of cell biology viz. cell cycles and cell lineages. Although reprogramming has been demonstrated experimentally, much of the underlying processes governing ...
arxiv +1 more source
An efficient platform for astrocyte differentiation from human induced pluripotent stem cells [PDF]
, 2017 Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Abdelaal, Rawan +13 more
core +3 more sources
Genes & Development, 2017 Bulstrode et al. show that increased expression of FOXG1 and SOX2 restricts astrocyte differentiation and can trigger dedifferentiation to a proliferative neural stem cell state.
H. Bulstrode +14 more
semanticscholar +1 more source
Shared and Divergent Epigenetic Mechanisms in Cachexia and Sarcopenia
Cells, 2022 Significant loss of muscle mass may occur in cachexia and sarcopenia, which are major causes of mortality and disability. Cachexia represents a complex multi-organ syndrome associated with cancer and chronic diseases.
Laura Yedigaryan +4 more
doaj +1 more source
The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis [PDF]
, 2009 Neural stem cell self-renewal, neurogenesis, and cell fate determination are processes that control the generation of specific classes of neurons at the correct place and time. The transcription factor Pax6 is essential for neural stem cell proliferation,
A Faedo +75 more
core +3 more sources