Results 61 to 70 of about 417,177 (325)
Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disorders
Neurobiology of Disease, 2020 Intrabodies (both single-chain Fv and single-domain VH, VHH, and VL nanobodies) offer unique solutions to some of the challenges of delivery and target engagement posed by immunotherapeutics for the brain and other areas of the nervous system.
Anne Messer, David C. Butler
doaj
Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus. [PDF]
, 2017 The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV).
Lane, Thomas E +4 more
core +1 more source
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation
Nature Communications, 2019 The hepatopancreatic ductal (HPD) system connects both liver and pancreas to the intestine but the molecular details of HPD development are unclear. Here, the authors describe how regionalised Eph/Ephrin signaling regulates HPD morphogenesis by promoting
M. Ilcim Thestrup +9 more
doaj +1 more source
Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy
Cell Death and Disease, 2021 Mesenchymal stem cell transplantation (MSCT) has been recognized as a potent and promising approach to achieve immunomodulation and tissue regeneration, but the mechanisms of how MSCs exert therapeutic effects remain to be elucidated. Increasing evidence
Yu Fu +6 more
doaj +1 more source
MMP2 Modulates Inflammatory Response during Axonal Regeneration in the Murine Visual System
Cells, 2021 Neuroinflammation has been put forward as a mechanism triggering axonal regrowth in the mammalian central nervous system (CNS), yet little is known about the underlying cellular and molecular players connecting these two processes.
Lien Andries +11 more
doaj +1 more source
Stem Cells in the Nervous System [PDF]
, 2014 Given their capacity to regenerate cells lost through injury or disease, stem cells offer new vistas into possible treatments for degenerative diseases and their underlying causes.
Doetsch, Fiona K. +5 more
core +1 more source
Neural Stem Cells and Neurogenesis in the Adult [PDF]
Cell Stem Cell, 2012 Research in the field of adult neurogenesis has seen substantial progress over recent years. Here we discuss some of the major focus areas for future investigation: neural stem cell heterogeneity, the role of latent stem cells, and the extent of neurogenesis in the adult human brain.
Göritz C, Frisén J.
openaire +3 more sources
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
Stem Cell Reports, 2015 Time-lapse microscopy can capture patterns of development through multiple divisions for an entire clone of proliferating cells. Images are taken every few minutes over many days, generating data too vast to process completely by hand.
Mark R. Winter +7 more
doaj +1 more source