Results 61 to 70 of about 421,776 (345)

Alterations of the Hippocampal Neurogenic Niche in a Mouse Model of Dravet Syndrome

Frontiers in Cell and Developmental Biology, 2020
Hippocampal neurogenesis, the process by which neural stem cells (NSCs) continuously generate new neurons in the dentate gyrus (DG) of most mammals including humans, is chiefly regulated by neuronal activity.
Soraya Martín-Suárez, Oihane Abiega, Ana Ricobaraza, Rubén Hernandez-Alcoceba, Juan Manuel Encinas, Juan Manuel Encinas, Juan Manuel Encinas   +6 more
doaj   +1 more source

Dynamic and Differential Regulation of Stem Cell Factor FoxD3 in the Neural Crest Is Encrypted in the Genome [PDF]

, 2012
The critical stem cell transcription factor FoxD3 is expressed by the premigratory and migrating neural crest, an embryonic stem cell population that forms diverse derivatives.
Bronner, Marianne E., McKeown, Sonja J., Sauka-Spengler, Tatjana, Simões-Costa, Marcos S., Tan-Cabugao, Joanne   +4 more
core   +3 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development

Nature Communications, 2023
The molecular mechanisms that coordinate patterning of the embryonic ectoderm into spatially distinct lineages to form the nervous system, epidermis, and neural crest-derived craniofacial structures are unclear.
Anthony J. Asmar, Shaun R. Abrams, Jenny Hsin, Jason C. Collins, Rita M. Yazejian, Youmei Wu, Jean Cho, Andrew D. Doyle, Samhitha Cinthala, Marleen Simon, Richard H. van Jaarsveld, David B. Beck, Laura Kerosuo, Achim Werner   +13 more
doaj   +1 more source

Disease-specific, neurosphere-derived cells as models for brain disorders [PDF]

, 2010
There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses.
Abrahamsen, G., An, J., Anderson, M., Beckhouse, A.G., Bellette, B., Bennebroek, M., Cecil, R., Chalk, A.M., Cochrane, J., Cook, A.L., Fan, Y., Féron, F., Mackay-Sim, A., Mahler, S., Matigian, N., McCurdy, R., McGrath, J.J., Mellick, G.D., Murrell, W., Nouwens, A., Perry, C., Raju, J., Ravishankar, S., Silburn, P.A., Sue, C.M., Sutharsan, R., Sutherland, G.T., Vitale, A.M., Wells, C.A., Wood, S.A.   +29 more
core   +1 more source

Neural Stem Cells and Neurogenesis in the Adult [PDF]

Cell Stem Cell, 2012
Research in the field of adult neurogenesis has seen substantial progress over recent years. Here we discuss some of the major focus areas for future investigation: neural stem cell heterogeneity, the role of latent stem cells, and the extent of neurogenesis in the adult human brain.
Göritz C, Frisén J.
openaire   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation

Nature Communications, 2019
The hepatopancreatic ductal (HPD) system connects both liver and pancreas to the intestine but the molecular details of HPD development are unclear. Here, the authors describe how regionalised Eph/Ephrin signaling regulates HPD morphogenesis by promoting
M. Ilcim Thestrup, Sara Caviglia, Jordi Cayuso, Ronja L. S. Heyne, Racha Ahmad, Wolfgang Hofmeister, Letizia Satriano, David G. Wilkinson, Jesper B. Andersen, Elke A. Ober   +9 more
doaj   +1 more source

Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy

Cell Death and Disease, 2021
Mesenchymal stem cell transplantation (MSCT) has been recognized as a potent and promising approach to achieve immunomodulation and tissue regeneration, but the mechanisms of how MSCs exert therapeutic effects remain to be elucidated. Increasing evidence
Yu Fu, Bingdong Sui, Lei Xiang, Xutong Yan, Di Wu, Songtao Shi, Xuefeng Hu   +6 more
doaj   +1 more source

Designing signaling environments to steer transcriptional diversity in neural progenitor cell populations [PDF]

, 2019
Stem cell populations within developing embryos are diverse, composed of many different subpopulations of cells with varying developmental potential. The structure of stem cell populations in cell culture remains poorly understood and presents a barrier ...
Chen, Sisi, Park, Jong H., Rivaud, Paul, Thomson, Matt, Tsou, Tiffany   +4 more
core