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Myelomeningocele (MMC) is the most common and severe type of spina bifida in which the developing spine and neural tube fail to close during prenatal development.
Hillary E. Swann‐Thomsen +4 more
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In vertebrates, the development of the central nervous system depends on the correct patterning of the neural tube along its anterior-posterior and dorsal-ventral axes in the early embryo as well as the underlying regulation of the cell differentiation ...
LIU Cong, XU Pengfei
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During primary neurulation, the separation of a single-layered ectodermal sheet into the surface ectoderm (SE) and neural tube specifies SE and neural ectoderm (NE) cell fates.
Chiharu Kimura-Yoshida +4 more
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A quest for genetic causes underlying signaling pathways associated with neural tube defects
Neural tube defects (NTDs) are serious congenital deformities of the nervous system that occur owing to the failure of normal neural tube closures. Genetic and non-genetic factors contribute to the etiology of neural tube defects in humans, indicating ...
Sunil Rai +4 more
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Introduction: Neural tube defects [PDF]
This volume of Neurosurgical Focus covers an array of topics useful to many specialists who care for patients with neural tube defects and related abnormalities. These patients have specific needs at each stage of the lifespan. Today, many individuals with significant developmental abnormalities of the spinal cord are leading full lives.
Shenandoah, Robinson +3 more
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The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice
Shroom3 is an actin-associated regulator of cell morphology that is required for neural tube closure, formation of the lens placode, and gut morphogenesis in mice and has been linked to chronic kidney disease and directional heart looping in humans ...
Debamitra Das +5 more
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Pax3/7 regulates neural tube closure and patterning in a non-vertebrate chordate
Pax3/7 factors play numerous roles in the development of the dorsal nervous system of vertebrates. From specifying neural crest at the neural plate borders, to regulating neural tube closure and patterning of the resulting neural tube.
Kwantae Kim +2 more
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Background: Neural tube defects are one of the most common malformations with a worldwide prevalence of 1–3 per1000 live births. They are the result of failure of the neural tube to close during the 21–28 embryonic days and it had multi-factorial ...
Filmawit Aynalem Tesfay +2 more
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Background Neural tube defects are common group of central nervous system anomalies of complex etiology and major public health importance worldwide. The occurrence of multiple neural tube defects, however, is an extremely rare event and has never been ...
Mestet Yibeltal Shiferaw +5 more
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Molecular and morphogenetic features of neurulation
Neurulation occurs by two different mechanisms, called primary and secondary neurulation. In humans, primary neurulation occurs along most of the rostrocaudal axis of the embryo, while secondary neurulation occurs caudally, only in the lower sacral and ...
N. M. Nevmerzhytska +5 more
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