Results 1 to 10 of about 9,274 (119)

An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs) [PDF]

Expert Opinion on Drug Metabolism and Toxicology, 2020
Vittorio Unfer, Andrew Copp, Nicholas D.E. Greene   +2 more
exaly   +2 more sources

A quest for genetic causes underlying signaling pathways associated with neural tube defects

Frontiers in Pediatrics, 2023
Neural tube defects (NTDs) are serious congenital deformities of the nervous system that occur owing to the failure of normal neural tube closures. Genetic and non-genetic factors contribute to the etiology of neural tube defects in humans, indicating ...
Sunil Rai, Larissa Leydier, Shivani Sharma, Jigar Katwala, Anurag Sahu   +4 more
doaj   +1 more source

Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway

Epigenetics & Chromatin, 2021
Neural tube defects (NTDs) remain one of the most life-threatening birth defects affecting infants. Most patients with NTDs eventually develop lifelong disability, which cause significant morbidity and mortality and seriously reduce the quality of life ...
Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu, Jun Xu, Jun Xie   +10 more
doaj   +1 more source

Primary (congenital) occipital encephalomeningocele in a newborn born to a mother despite folic acid supplementation

Clinical Case Reports, 2023
Key Clinical Message The etiology of neural tube defects is multifactorial, with a wide interplay of genetic and environmental factors. However, periconceptional folic acid should be supplemented in antenatal care.
Binod Paudel, Gopal K. Yadav
doaj   +1 more source

Loss‐of‐Function of p21‐Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects

Advanced Science, 2023
Closure of the neural tube represents a highly complex and coordinated process, the failure of which constitutes common birth defects. The serine/threonine kinase p21‐activated kinase 2 (PAK2) is a critical regulator of cytoskeleton dynamics; however ...
Yan Wang, Kaifan Zhang, Jin Guo, Shuyan Yang, Xiaohui Shi, Jinrong Pan, Zheng Sun, Jizhen Zou, Yi Li, Yuanyuan Li, Tianda Fan, Wei Song, Fang Cheng, Cheng Zeng, Jinchen Li, Ting Zhang, Zhong Sheng Sun   +16 more
doaj   +1 more source

Magnitude and determinants of neural tube defect in Africa: a systematic review and meta-analysis

BMC Pregnancy and Childbirth, 2021
Background Neural tube defects (NTDs) are a group of disorders that arise from the failure of the neural tube close between 21 and 28 days after conception.
Daniel Atlaw, Yohannes Tekalegn, Biniyam Sahiledengle, Kenbon Seyoum, Damtew Solomon, Habtamu Gezahegn, Zerihun Tariku, Yared Tekle, Vijay Kumar Chattu   +8 more
doaj   +1 more source

Cilia and their role in neural tube development and defects

Reproductive and Developmental Medicine, 2022
. Cilia are microtubule-based filamentous organelles that play a vital role in embryogenesis. Multiple signal transduction pathways are orchestrated by cilia, such as Hedgehog and planar cell polarity signals.
Lu Yan, Yu-Fang Zheng, Yong-Qing Zhu
doaj   +1 more source

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Cell Reports, 2019
Summary: Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete penetrance. We found that the combined loss of pro-apoptotic BIM and p53
Alex R.D. Delbridge, Andrew J. Kueh, Francine Ke, Natasha M. Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E. May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J. Herold, Ygal Haupt, Gordon K. Smyth, Tim Thomas, Marnie E. Blewitt, Andreas Strasser, Anne K. Voss   +21 more
doaj   +1 more source

Impact of MTHFR and RFC-1 gene in the development of neural tube defect [PDF]

Journal of Cell and Molecular Research, 2014
Neural tube defects (NTDs) are complex problem of central nervous system including brain and spinal cord. Anencephaly and myelomeningocele are the two most common forms of NTDs.
Rinki Kumari, Aruna Agrawal, Om Prakash Upadhyaya, Gure Prit Inder Singh, Govind Prasad Dubey   +4 more
doaj   +1 more source

Syndromes, Disorders and Maternal Risk Factors Associated with Neural Tube Defects (II)

Taiwanese Journal of Obstetrics & Gynecology, 2008
Summary: Fetuses with neural tube defects (NTDs) maybe associated with syndromes, disorders, and maternal risk factors. This article provides a comprehensive review of syndromes, disorders, and maternal risk factors associated with NTDs, such as ...
Chih-Ping Chen
doaj   +1 more source