Results 1 to 10 of about 12,096 (222)

The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China. [PDF]

Oncotarget, 2017
BACKGROUND: Although a number of studies have reported the recurrence risk of NTDs in developed countries, there is little data on the rate of recurrence of NTDs in northern China, a region of high prevalence of NTDs.
Liu J, Li Z, Greene NDE, Li H, Ren A.
europepmc   +6 more sources

An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs). [PDF]

Expert Opin Drug Metab Toxicol, 2020
Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs).In view of the recent knowledge, changes in nutritional and physical activity habits ...
Facchinetti F, Cavalli P, Copp AJ, D'Anna R, Kandaraki E, Greene NDE, Unfer V, Experts Group on Inositol in Basic and Clinical Research.   +7 more
europepmc   +12 more sources

The silent tragic reality of Hidden Hunger, anaemia, and neural-tube defects (NTDs) in India. [PDF]

Lancet Reg Health Southeast Asia, 2022
Hidden Hunger arising from nutritional iron-, folate-, and vitamin-B12-deficiencies is exceedingly common in India and has profound negative impacts on anaemia, on pregnancy, and on embryonic-foetal neurodevelopment in utero, which predisposes to NTDs and psychological-psychiatric manifestations in childhood. Whereas younger-to-middle-aged Indians fail
Antony AC, Vora RM, Karmarkar SJ.
europepmc   +4 more sources

Evaluation of Neural Tube Defects (NTDs) After Exposure to Raltegravir During Pregnancy. [PDF]

J Acquir Immune Defic Syndr, 2019
Objective: To evaluate the risk of neural tube defects (NTDs) after exposure to raltegravir during pregnancy. Methods: Exposures to raltegravir during pregnancy reported cumulatively through May 31, 2018, to the company safety database were reviewed to identify cases of NTDs.
Shamsuddin H, Raudenbush CL, Sciba BL, Zhou YP, Mast TC, Greaves WL, Hanna GJ, Leong R, Straus W.   +8 more
europepmc   +4 more sources

No Evidence of Impact of Genetic Sex on Hyperthermia-Induced Neural Tube Defects in Chicken Embryos. [PDF]

Birth Defects Res
ABSTRACT Background In mammals, cranial neural tube defects (NTDs) are more likely to occur in females. It has been proposed that the sex bias in NTDs was due to the presence of the inactive X chromosome in the somatic cells of female embryos and that the inactive X acted as a heterochromatic sink, competing for silencing factors with the rest of the ...
Wang Y, Ryan AK, Naumova AK.
europepmc   +2 more sources

Roles of planar cell polarity pathways in the development of neutral tube defects [PDF]

Journal of Biomedical Science, 2011
Neural tube defects (NTDs) are the second most common birth defect in humans. Despite many advances in the understanding of NTDs and the identification of many genes related to NTDs, the fundamental etiology for the majority of cases of NTDs remains ...
Hua Yimin, Huang Xupei, Wu Gang, Mu Dezhi   +3 more
doaj   +2 more sources

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids. [PDF]

Adv Sci (Weinh)
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Li H, Zhang J, Bulwith L, Niswander L.
europepmc   +2 more sources

Ameliorative Effect of Beetroot Against Folic Acid Deficiency: A Review. [PDF]

Food Sci Nutr
Beets, as well as folic acid supplements, provide a possible nutritional intervention for nutritional insufficiency, and this is especially true in functional foods. Offering a holistic explanation of beetroot's medicinal properties, this paper explores the means by which its bioactive constituents can counteract the adverse effects of folic acid ...
Rasheed A, Saeed F, Ikram A, Arshad MT, Maqsood S, Naveed F, Islam M, Laryea E.   +7 more
europepmc   +2 more sources

A quest for genetic causes underlying signaling pathways associated with neural tube defects

Frontiers in Pediatrics, 2023
Neural tube defects (NTDs) are serious congenital deformities of the nervous system that occur owing to the failure of normal neural tube closures. Genetic and non-genetic factors contribute to the etiology of neural tube defects in humans, indicating ...
Sunil Rai, Larissa Leydier, Shivani Sharma, Jigar Katwala, Anurag Sahu   +4 more
doaj   +1 more source

Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway

Epigenetics & Chromatin, 2021
Neural tube defects (NTDs) remain one of the most life-threatening birth defects affecting infants. Most patients with NTDs eventually develop lifelong disability, which cause significant morbidity and mortality and seriously reduce the quality of life ...
Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu, Jun Xu, Jun Xie   +10 more
doaj   +1 more source