Results 11 to 20 of about 12,096 (222)
Annual Review of Neuroscience, 2014 Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth defects of the central nervous system that originate during embryonic development when the neural tube fails to close completely.
Copp, AJ, Greene, ND
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Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. [PDF]
Nature Communications, 2015 Glycine decarboxylase (GLDC) acts in the glycine cleavage system to decarboxylate glycine and transfer a one-carbon unit into folate one-carbon metabolism. GLDC mutations cause a rare recessive disease non-ketotic hyperglycinemia (NKH).
Brosnan, JT +9 more
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The Professional Medical Journal, 2017 Background: The most common congenital malformations are Neural tubedefects (NTDs) occurring in 0.6 per 1,000 live births in the United States, and almost 4000pregnancies are recorded of babies with neural tube defects, among them anencephalyand Spina bifida are the most common and their annual incidence is 2,500 to 3,000 births inthe United States ...
Nadeem Shahzad +3 more
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Clinical Case Reports, 2023 Key Clinical Message The etiology of neural tube defects is multifactorial, with a wide interplay of genetic and environmental factors. However, periconceptional folic acid should be supplemented in antenatal care.
Binod Paudel, Gopal K. Yadav
doaj +1 more source
Loss‐of‐Function of p21‐Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects
Advanced Science, 2023 Closure of the neural tube represents a highly complex and coordinated process, the failure of which constitutes common birth defects. The serine/threonine kinase p21‐activated kinase 2 (PAK2) is a critical regulator of cytoskeleton dynamics; however ...
Yan Wang +16 more
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From genes to neural tube defects (NTDs): Insights from multiscale computational modeling [PDF]
HFSP Journal, 2010 The morphogenetic movements, and the embryonic phenotypes they ultimately produce, are the consequence of a series of events that involve signaling pathways, cytoskeletal components, and cell- and tissue-level mechanical interactions. In order to better understand how these events work together in the context of amphibian neurulation, an existing ...
G Wayne, Brodland +3 more
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Magnitude and determinants of neural tube defect in Africa: a systematic review and meta-analysis
BMC Pregnancy and Childbirth, 2021 Background Neural tube defects (NTDs) are a group of disorders that arise from the failure of the neural tube close between 21 and 28 days after conception.
Daniel Atlaw +8 more
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Cilia and their role in neural tube development and defects
Reproductive and Developmental Medicine, 2022 . Cilia are microtubule-based filamentous organelles that play a vital role in embryogenesis. Multiple signal transduction pathways are orchestrated by cilia, such as Hedgehog and planar cell polarity signals.
Lu Yan, Yu-Fang Zheng, Yong-Qing Zhu
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ETERNAL SERUM ALPHA-FETOPROTEIN (AFP) SCREENING FOR NEURAL TUBE DEFECTS (NTDS) [PDF]
Pediatric Research, 1977 About 90% of NTDs occur without a history of an affected sibling or parent. From available data, routine screening of all 2nd trimester maternal sera has the potential of early prenatal detection of 60-80% of anencephaly and 30-50% of spina bifida. Me have done radioimmunoassays on 1608 maternal sera collected mainly from patients attending for routine
Aubrey Milunsky +2 more
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Cell Reports, 2019 Summary: Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete penetrance. We found that the combined loss of pro-apoptotic BIM and p53
Alex R.D. Delbridge +21 more
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