Results 31 to 40 of about 12,096 (222)

Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects

Cell Death and Disease, 2021
Impaired autophagy and excessive apoptosis disrupt cellular homeostasis and contribute to neural tube defects (NTDs), which are a group of fatal and disabling birth defects caused by the failure of neural tube closure during early embryonic development ...
Wanqi Huang, Tianchu Huang, Yusi Liu, Jialin Fu, Xiaowei Wei, Dan Liu, Wei Ma, Hui Gu, Zhengwei Yuan   +8 more
doaj   +1 more source

Alcohol induces neural tube defects by reducing retinoic acid signaling and promoting neural plate expansion

Frontiers in Cell and Developmental Biology, 2023
Introduction: Neural tube defects (NTDs) are among the most debilitating and common developmental defects in humans. The induction of NTDs has been attributed to abnormal folic acid (vitamin B9) metabolism, Wnt and BMP signaling, excess retinoic acid (RA)
Tamir Edri, Dor Cohen, Yehuda Shabtai, Abraham Fainsod   +3 more
doaj   +1 more source

Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects

Nature Communications, 2018
Elevated maternal homocysteine (Hcy) increases the risk for neural tube defects (NTDs) but how this arises is unclear. Here, the authors show that high levels of Hcy on histone H3K79Hcy correlate with NTDs, causing abnormal gene expression (for example ...
Qin Zhang, Baoling Bai, Xinyu Mei, Chunlei Wan, Haiyan Cao, Dan Li, Shan Wang, Min Zhang, Zhigang Wang, Jianxin Wu, Hongyan Wang, Junsheng Huo, Gangqiang Ding, Jianyuan Zhao, Qiu Xie, Li Wang, Zhiyong Qiu, Shiming Zhao, Ting Zhang   +18 more
doaj   +1 more source

Loss‐of‐function or gain‐of‐function variations in VINCULIN (VCL) are risk factors of human neural tube defects

Molecular Genetics & Genomic Medicine, 2021
Background Neural tube defects (NTDs) are severe birth defects resulting from the failure of neural tube closure during embryogenesis. Both genetic and environmental factors contribute to the occurrence of NTDs and the heritability of NTDs is ...
Yalan Wang, Yue Qin, Rui Peng, Hongyan Wang   +3 more
doaj   +1 more source

Impact of prenatal exposure to metallic elements on neural tube defects: Insights from human investigations

Ecotoxicology and Environmental Safety, 2023
Metallic elements play a pivotal role in maternal and fetal health. Metals can cross the placental barrier and be absorbed by fetuses, where they may affect closure of the neural tube during embryonic development. Neural tube defects (NTDs), which result
Wanqi Huang, Jialin Fu, Zhengwei Yuan, Hui Gu   +3 more
doaj   +1 more source

EXPERIENCE WITH α-FETOPROTEIN (AFP) IN PRENATAL DIAGNOSIS OF NEURAL TUBE DEFECTS (NTD) [PDF]

Pediatric Research, 1974
The use of AFP assays of amniotic fluid (AF) as a diagnostic adjunct to the prenatal diagnosis of these defects represents the most significant advance yet in prevention through early detection. AFP assays by electroimmunodiffusion were done on AF's derived from 525 cases (10-34 weeks gestation) with subsequent normal births.
Aubrey Milunsky, Elliot Alpert
openaire   +1 more source

Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis. [PDF]

, 2015
BACKGROUND: In the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth
Allagh, Komal Preet, Doyle, Pat, Murthy, Gudlavalleti VS, Neogi, Sutapa B, Ness, Andy R, Pant, Hira B, Shamanna, BR, Wellcome Trust- PHFI Folic Acid project team   +7 more
core   +10 more sources

The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice

Disease Models & Mechanisms, 2022
Neural tube defects (NTDs) are among the common and severe birth defects with poorly understood etiology. Mutations in the Wnt co-receptor LRP6 are associated with NTDs in humans.
Tianyu Zhao, Moira McMahon, Kurt Reynolds, Subbroto Kumar Saha, Arjun Stokes, Chengji J. Zhou   +5 more
doaj   +1 more source

Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice [PDF]

, 2018
Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass is ...
A Kamalakar, A Trinh, AJ Copp, AJ Copp, AS Findlay, B Wang, BA Alman, C Cooper, C Hartmann, CF Davey, CH Chen, D Karasik, D Szklarczyk, DG Winkler, DJ Epstein, DM Juriloff, E Canalis, E Nikolopoulou, EM Curtis, GH Li, GL Galea, GL Galea, GL Galea, GL Galea, H Marreiros, H Yin, HF Zheng, IR Orriss, IR Orriss, JK Morris, JN Murdoch, K Estrada, KC Keller, KS Joeng, L D’Andrea, LJ Martin, LL Yates, LL Yates, M Akbar, M Kalogeropoulos, ME Ross, MJ Anderson, MJ Harris, MJ Harris, MR Dohn, NC Nowlan, P Andre, P Elms, P Ybot-Gonzalez, P Ybot-Gonzalez, R Klootwijk, R Xu, S Babayeva, S Li, S Maere, SA Brown, SE Taylor, SJ Conway, T Dodge, T Yang, UM Ayturk, V Martinelli, W Yang, Y Erdem, Y Koyabu, Y Lei, Z Kibar   +66 more
core   +3 more sources

THE CONTRIBUTION OF COBALAMINE METABOLISM TO GENETIC LIABILITY OF NEURAL TUBE DEFECTS (NTD) [PDF]

Pediatric Research, 1992
To check the hypothesis that alteration of cobalamine metabolism may contribute to the etiology of NTD, serum and amniotic fluid levels of total transcobalamlnes (STTC, FTTC) and transcobalamine II (STCII, FTCII) were studied in the pregnancies of high and low risk for NTD development.
Jacek J Pietrzyk, Marek Sanak, Magdalena Korecka, Piotr Sucharski   +3 more
openaire   +1 more source