Results 51 to 60 of about 9,343 (179)

Ethionine Suppresses Mitochondria Autophagy and Induces Apoptosis via Activation of Reactive Oxygen Species in Neural Tube Defects

Frontiers in Neurology, 2020
Abnormal development of central nervous system (CNS) caused by neural tube defects (NTDs) is not only remained the major contributor in the prevalence of stillbirths and neonatal deaths, but also represents a significant cause of lifelong physical ...
Li Zhang, Yanting Dong, Wenzhuo Wang, Taoran Zhao, Tingjuan Huang, Ajab Khan, Lei Wang, Zhizhen Liu, Jun Xie, Bo Niu, Bo Niu   +10 more
doaj   +1 more source

Serum Folate Concentration Corresponding to the Red Blood Cell Folate Threshold for Increased Risk of Neural Tube Defects Among Ethiopian Women of Reproductive Age

Maternal &Child Nutrition, EarlyView.
ABSTRACT Neural tube defects (NTDs) are severe birth defects linked to insufficient maternal folate status during early pregnancy. Red blood cell (RBC) folate concentration is the recommended biomarker for predicting NTD risk, with a threshold of 748 nmol/L using the US Centers for Disease Control and Prevention (CDC) microbiological assay. However, in
Biniyam Tesfaye, Meseret Woldeyohannes, Masresha Tessema, Charles Dale Arnold, Christine M. McDonald, Kenneth H. Brown   +5 more
wiley   +1 more source

The Frequency And Distribution Of Neural Tube Defects (NTDs) at Arthur Davison Children Hospital (ADCH)

, 2021
Background: Neural Tube Defects (NTDs) are the world's second most common birth defects after cardiovascular defects. In developing countries like Zambia, these defects are unrecognized and under reported. Despite the administration of folic acid, there have been incidences of NTDs though no local literature points out the frequency of these defects ...
Poster, Mutambo, Siapiila, Paul
openaire   +3 more sources

Interaction of folate and homocysteine pathway genotypes evaluated in susceptibility to neural tube defects (NTD) in a German population [PDF]

Journal of Human Genetics, 2001
Neural tube defects (NTD) are likely to result from an interaction of several genes and environmental factors. Because periconceptional folate intake reduces the NTD risk in the fetus, and because mothers of children with NTD showed elevated plasma homocysteine levels, gene polymorphisms of the folate and homocysteine pathway, such as 5,10 ...
B, Richter, K, Stegmann, B, Röper, I, Böddeker, E T, Ngo, M C, Koch   +5 more
openaire   +2 more sources

Co‐Occurring Non‐Cardiac Congenital Anomalies Among Cases With Congenital Heart Defects

American Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 1953-1972, September 2026.
ABSTRACT Cases with congenital heart defects (CHD) often have other associated anomalies. The aim of this investigation was to assess the prevalence and the types of co‐occurring anomalies in CHD in a well‐defined population. The anomalies co‐occurring with CHD were ascertained in all live births, stillbirths and terminations of pregnancy for fetal ...
Claude Stoll, Yves Alembik, Marie‐Paule Roth   +2 more
wiley   +1 more source

Birth prevalence and determinants of neural tube defects among newborns in Ethiopia: A systematic review and meta-analysis.

PLoS ONE
BackgroundNeural tube defects (NTDs) are complex multifactorial disorders in the neurulation of the brain and spinal cord that develop in humans between 21 and 28 days of conception.
Beminet Moges Gebremariam, Dejene Hailu, Barbara J Stoecker, Afework Mulugeta   +3 more
doaj   +1 more source

Neighborhood Economic Deprivation, Hispanic Ethnic Enclaves, and Congenital Anomalies in Texas

Birth Defects Research, Volume 118, Issue 9, September 2026.
ABSTRACT Background Congenital anomalies are common, costly, and potentially life‐threatening. The impacts of structural determinants of health on risk for these conditions have scarcely been studied. We evaluated associations between residence in economically disadvantaged neighborhoods or Hispanic/Latino enclaves and congenital anomalies.
Jeremy M. Schraw, Rutu A. Rathod, Amy E. Hughes, Sandi L. Pruitt, Russell S. Kirby, Gary M. Shaw, Philip J. Lupo   +6 more
wiley   +1 more source

Abnormal methylation caused by folic acid deficiency in neural tube defects

Open Life Sciences, 2022
Neural tube closure disorders, including anencephaly, spina bifida, and encephalocele, cause neural tube defects (NTDs). This congenital disability remained not only a major contributor to the prevalence of stillbirths and neonatal deaths but also a ...
Cao Rui, Xie Jun, Zhang Li
doaj   +1 more source

Genomic Contributors to Congenital Diaphragmatic Hernia: Results of Exome Sequencing in 560 Probands and Cross Reference of Findings in an Independent Cohort

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1821-1831, August 2026.
ABSTRACT There is a strong genetic contribution to the etiology of congenital diaphragmatic hernia (CDH). This study evaluated genetic testing results and diagnostic yield for fetuses and children with CDH. This was a retrospective cohort study of exome sequencing (ES) performed at GeneDx for fetuses and children ≤ 18 years of age with CDH compared ...
Justin Blair, Kevin Carratu, Natalie E. Rintoul, Holly L. Hedrick, William H. Peranteau, Catherine M. Avitabile, Kirsty McWalter, Paul Kruszka, Ian D. Krantz, K. Taylor Wild   +9 more
wiley   +1 more source

Neural tube defects in a war-torn Tigray regional state of Ethiopia: a retrospective study of 54,626 deliveries

BMC Pregnancy and Childbirth
Background The Tigray region of Ethiopia has a significantly high prevalence of neural tube defects (NTDs), ranging from 1.31 to 2.15% of total births. The prevalence has worsened due to ongoing regional war and conflict since October 2020.
Birhane Alem Berihu, Afework Mulugeta, Tony Magana, Masresha Tessema, Tafere Gebreegziabher, Yibrah Berhe, Abadi Leul Welderufael, Hayelom Kebede Mekonen   +7 more
doaj   +1 more source