Results 61 to 70 of about 9,343 (179)

Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects

Cell Death and Disease, 2021
Wnt signaling plays a major role in early neural development. An aberrant activation in Wnt/β-catenin pathway causes defective anteroposterior patterning, which results in neural tube closure defects (NTDs).
Jianting Li, Qiu Xie, Jun Gao, Fang Wang, Yihua Bao, Lihua Wu, Lihong Yang, Zhizhen Liu, Rui Guo, Ajab Khan, Dan Liu, Caihua Li, Jianxin Wu, Jun Xie   +13 more
doaj   +1 more source

Pericerebral spaces as diagnostic signposts in fetal central nervous system pathologies

Ultrasound in Obstetrics &Gynecology, EarlyView.
L. Guibaud, S. Cabet
wiley   +1 more source

A Mechanistic Review of Environmental Stressor to Decode Their Effect on Congenital Malformations: A Developmental Toxicity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Environmental toxicants may disrupt developmental pathways via strong molecular docking interactions with hub FGF proteins (FGF9 and FGF4) like dibenzo‐p‐dioxin (−7.2 kcal/mol) at the ASN146 residue of FGF9, driving congenital malformations as revealed by PPI networks and toxicity profiling.
Adarsh Kumar Shukla, Rashmi Mahajan, Anuj Kumar Tyagi, Kamendra Swaroop   +3 more
wiley   +1 more source

Research progress on ultrasound and molecular markers for prenatal diagnosis of neural tube defects

Heliyon
Neural tube defects (NTDs) are severe congenital anomalies that result from the failure of early neural tube closure during fetal neurogenesis. They are the most common and severe congenital malformations of the central nervous system.
Jiao Yin, Yan Wang, Sihong Wang, Gang Li, Hui Gu, Lizhu Chen   +5 more
doaj   +1 more source

Falling Use of Preconception Folic Acid Supplements and Neural Tube Defect Prevention

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
Danielle Schoenaker, Judith Stephenson, Anna L. David, Sanhita Chakrabarti, Keith M. Godfrey   +4 more
wiley   +1 more source

Detection and Clinical Significance of Chromosomal Mosaicism in Prenatal Diagnosis: A Retrospective Study From a Prenatal Diagnosis Center

Journal of Clinical Laboratory Analysis, Volume 40, Issue 16, August 2026.
This retrospective study of 79 prenatal mosaicism cases found that noninvasive prenatal testing (NIPT) had significantly higher sensitivity (90.74%) than first‐ and second‐trimester serum screening, while chromosomal microarray analysis (CMA) showed better concordance with karyotyping (90.00%) than QF‐PCR (58.21%).
Yuanyuan Pei, Xiaojin Luo, Jian Ran, Liang Hu, Weiqiang Liu, Fengxiang Wei   +5 more
wiley   +1 more source

Identification of histone acetylation markers in human fetal brains and increased H4K5ac expression in neural tube defects

Molecular Genetics & Genomic Medicine, 2019
Background Neural tube defects (NTDs) are severe common birth defects that result from a failure in neural tube closure (NTC). Our previous study has shown that decreased histone methylation altered the regulation of genes linked to NTC.
Dan Li, Chunlei Wan, Baoling Bai, Haiyan Cao, Changyun Liu, Qin Zhang   +5 more
doaj   +1 more source

Craniospinal rachischisis with multiple anomalies in an anencephalic fetus: A rare case report

Journal of the Scientific Society, 2014
Neural tube defects (NTDs) are the most common malformations accounting for 0.5-1.3 cases/1000 live births with multifactorial etiology. Anencephaly and craniospinal rachischisis are open NTDs.
Hema Basappa Bannur, Vijayalaxmi V Suranagi, Reshma Davanageri, Ganga S Pilli   +3 more
doaj   +1 more source

Functional Validation of CLDN Variants Identified in a Neural Tube Defect Cohort Demonstrates Their Contribution to Neural Tube Defects

Frontiers in Neuroscience, 2020
Neural tube defects (NTDs) are severe malformations of the central nervous system that affect 1–2 individuals per 2,000 births. Their etiology is complex and involves both genetic and environmental factors.
Amanda I. Baumholtz, Amanda I. Baumholtz, Patrizia De Marco, Valeria Capra, Aimee K. Ryan, Aimee K. Ryan, Aimee K. Ryan   +6 more
doaj   +1 more source

Abnormal Enteric Nervous System Organization and Gastrointestinal Motility in Mice With Valproic Acid‐Induced Neural Tube Defects

Neurogastroenterology &Motility, Volume 38, Issue 6, June 2026.
Gastrointestinal tracts from fetuses with a valproic acid‐induced neural tube defect contain blood. Structurally, the enteric neuronal stripes are thinner with a narrower interstripe distance, leading to an increased number of stripes. Functionally, gastrointestinal motility is abnormal, with increased contraction frequency and increased length of ...
Gabrielle R. Barsh, Kelbi Banducci, Julia A. Kaltschmidt   +2 more
wiley   +1 more source