Results 81 to 90 of about 12,096 (222)

Neural tube defects in a war-torn Tigray regional state of Ethiopia: a retrospective study of 54,626 deliveries

BMC Pregnancy and Childbirth
Background The Tigray region of Ethiopia has a significantly high prevalence of neural tube defects (NTDs), ranging from 1.31 to 2.15% of total births. The prevalence has worsened due to ongoing regional war and conflict since October 2020.
Birhane Alem Berihu, Afework Mulugeta, Tony Magana, Masresha Tessema, Tafere Gebreegziabher, Yibrah Berhe, Abadi Leul Welderufael, Hayelom Kebede Mekonen   +7 more
doaj   +1 more source

Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects

Cell Death and Disease, 2021
Wnt signaling plays a major role in early neural development. An aberrant activation in Wnt/β-catenin pathway causes defective anteroposterior patterning, which results in neural tube closure defects (NTDs).
Jianting Li, Qiu Xie, Jun Gao, Fang Wang, Yihua Bao, Lihua Wu, Lihong Yang, Zhizhen Liu, Rui Guo, Ajab Khan, Dan Liu, Caihua Li, Jianxin Wu, Jun Xie   +13 more
doaj   +1 more source

Real World Evidence Versus Randomised Controlled Trials: Is the Future of Nutritional Sciences Research in Electronic Health Records?

Nutrition Bulletin, Volume 51, Issue 1, Page 38-45, March 2026.
ABSTRACT Randomised controlled trials (RCTs) are the gold standard of research studies. They aim to recruit participants with similar characteristics and randomly assign them to a treatment or control/placebo arm. Due to randomisation, RCTs provide comprehensive, unbiased evidence about treatment efficacy and safety and examine cause‐and‐effect ...
Kathryn V. Dalrymple
wiley   +1 more source

Research progress on ultrasound and molecular markers for prenatal diagnosis of neural tube defects

Heliyon
Neural tube defects (NTDs) are severe congenital anomalies that result from the failure of early neural tube closure during fetal neurogenesis. They are the most common and severe congenital malformations of the central nervous system.
Jiao Yin, Yan Wang, Sihong Wang, Gang Li, Hui Gu, Lizhu Chen   +5 more
doaj   +1 more source

Teratogenic effects of gabapentin on neural tube and limb development in mice [PDF]

, 2008
[No abstract ...
Afshar, M., Golalipour, M.J.
core  

Fine mapping and candidate gene analysis of the CT mouse model of neural tube defects (NTD): an approach to identifying human NTD genes. ♦ 278 [PDF]

Pediatric Research, 1997
Neural tube defects (NTD) are the most common and severe CNS malformations. NTD are complex traits, involving interactions between environmental agents and multiple predisposing genes. The molecular basis for NTD is not understood. We are examining the curly tail (CT) mouse, the mutant which most closely resembles human NTD in both its genetic ...
Simon M Manning, Bruno P Granwehr, Merton Bernfield   +2 more
openaire   +1 more source

Epithelial fusion during neural tube morphogenesis [PDF]

, 2012
Adhesion and fusion of epithelial sheets marks the completion of many morphogenetic events during embryogenesis. Neural tube closure involves an epithelial fusion sequence in which the apposing neural folds adhere initially via cellular protrusions ...
Abdul-Aziz, Bader, Baudoin, Brouns, Camerer, Cecconi, Chen, Copp, Copp, Copp, Cremer, De Arcangelis, Dravis, Furman, Geelen, George, Glise, Hall, Holmberg, Hong, Hoving, Hynes, Jacinto, Jacinto, Jacobson, Kuan, Larue, Leonard, Martin, Massa, McLaughlin, Menzies, Merrill, Miner, Mirkes, Moase, Murai, Pyrgaki, Pyrgaki, Radice, Ridley, Rifat, Risley, Sabapathy, Schluter, Shimizu, Stephen, Sugihara, Taya, Van Straaten, Vasioukhin, Waterman, Weil, Werth, Weston, Wood, Woolner, Yamaguchi   +57 more
core   +1 more source

Interaction of folate and homocysteine pathway genotypes evaluated in susceptibility to neural tube defects (NTD) in a German population [PDF]

Journal of Human Genetics, 2001
Neural tube defects (NTD) are likely to result from an interaction of several genes and environmental factors. Because periconceptional folate intake reduces the NTD risk in the fetus, and because mothers of children with NTD showed elevated plasma homocysteine levels, gene polymorphisms of the folate and homocysteine pathway, such as 5,10 ...
B, Richter, K, Stegmann, B, Röper, I, Böddeker, E T, Ngo, M C, Koch   +5 more
openaire   +2 more sources

Maternal Myo‐Inositol Intake and Congenital Heart Defects in Offspring: A Population‐Based Case–Control Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 3, Page 442-453, February 2026.
ABSTRACT Objective To investigate associations between maternal periconceptional (three months prior through the third pregnancy month) myo‐inositol intake and the odds of selected congenital heart defects in offspring. Design A population‐based case–control study using the National Birth Defects Prevention Study (NBDPS) database. Setting United States.
Ruiqi Cen, L. Joseph Su, Jun Ying, Mohammed S. Orloff, Elijah H. Bolin, Xiangyang Lou, Lynn M. Almli, Lorenzo D. Botto, Marilyn L. Browne, Richard H. Finnell, Mary M. Jenkins, Eirini Nestoridi, Andrew F. Olshan, Paul A. Romitti, Gary M. Shaw, Wendy N. Nembhard, the National Birth Defects Prevention Study   +16 more
wiley   +1 more source

Cost‐Efficiency and Cost‐Effectiveness of Alternative Bouillon Fortification Programs: Evidence for Burkina Faso, Nigeria, and Senegal

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
Achieving dietary adequacy in vitamin A, zinc, and/or folate can save child‐lives. Different amounts and combinations of micronutrients have different costs and different effects on child mortality. This study presents ten bouillon fortification options for Nigeria.
Stephen A. Vosti, Michael Jarvis, Lauren Thompson, Emily Becher, Maguette Beye, Faith Ishaya, Karim Koudougou, Reina Engle‐Stone, Katherine P. Adams   +8 more
wiley   +1 more source