Results 91 to 100 of about 12,096 (222)

Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects [PDF]

, 2018
Neural tube defects (NTDs) are among the most common and severe congenital malformations and result from incomplete closure of the neural tube during early development. Maternal exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested to be
Greene, NDE, Huang, Y, Lin, S, Ren, A, Wang, C, Wang, L, Wang, Y   +6 more
core   +1 more source

Identifying Immune Cells as Mediators in the Impact of Gut Microbiota on Congenital Malformations of the Nervous System

Brain and Behavior, Volume 16, Issue 1, January 2026.
This study reveals causal links between gut microbiota and congenital nervous system malformations, identifying nine immune cell types, such as CD20+ and CD25+ B cells, as mediators, highlighting gut–immune interactions as potential preventive or therapeutic targets.
Haokun Tian, Xiaolan Guo, Jialu Yu, Yuanfang Lu, Wensen Cao, Xiuwei Wang, Zhiqiang Zhu, Zhen Guan, Aiyun Yang, Shen Li, Xiaochun Xu, Caihua Wang, Jianhua Wang   +12 more
wiley   +1 more source

Organ‐Specific Histopathological Effects of Prenatal Alcohol Exposure: A Narrative Review

Congenital Anomalies, Volume 66, Issue 1, January/December 2026.
ABSTRACT The role of alcohol‐induced epigenetic modifications that predispose the fetus to metabolic dysregulation, increased susceptibility to future substance use, and long‐term behavioral and cognitive impairments has received increasing attention.
Rana Nur Gursu, Dilan Cetinavci, Hulya Elbe   +2 more
wiley   +1 more source

Identification of histone acetylation markers in human fetal brains and increased H4K5ac expression in neural tube defects

Molecular Genetics & Genomic Medicine, 2019
Background Neural tube defects (NTDs) are severe common birth defects that result from a failure in neural tube closure (NTC). Our previous study has shown that decreased histone methylation altered the regulation of genes linked to NTC.
Dan Li, Chunlei Wan, Baoling Bai, Haiyan Cao, Changyun Liu, Qin Zhang   +5 more
doaj   +1 more source

Craniospinal rachischisis with multiple anomalies in an anencephalic fetus: A rare case report

Journal of the Scientific Society, 2014
Neural tube defects (NTDs) are the most common malformations accounting for 0.5-1.3 cases/1000 live births with multifactorial etiology. Anencephaly and craniospinal rachischisis are open NTDs.
Hema Basappa Bannur, Vijayalaxmi V Suranagi, Reshma Davanageri, Ganga S Pilli   +3 more
doaj   +1 more source

Functional Validation of CLDN Variants Identified in a Neural Tube Defect Cohort Demonstrates Their Contribution to Neural Tube Defects

Frontiers in Neuroscience, 2020
Neural tube defects (NTDs) are severe malformations of the central nervous system that affect 1–2 individuals per 2,000 births. Their etiology is complex and involves both genetic and environmental factors.
Amanda I. Baumholtz, Amanda I. Baumholtz, Patrizia De Marco, Valeria Capra, Aimee K. Ryan, Aimee K. Ryan, Aimee K. Ryan   +6 more
doaj   +1 more source

Association of retinoic acid receptor genes with meningomyelocele. [PDF]

, 2010
BACKGROUND: Neural tube defects (NTDs) occur in as many as 0.5-2 per 1000 live births in the United States. One of the most common and severe neural tube defects is meningomyelocele (MM) resulting from failed closure of the caudal end of the neural tube.
Au, Kit Sing, Fletcher, Jack M, Morrison, Alanna C, Northrup, Hope, Ostermaier, Kathryn K, Tran, Phong X, Tyerman, Gayle H   +6 more
core   +1 more source

SNRI (Venlafaxine) induces Neural Tube Defects (NTDs) in Developing Chick Embryos

Journal of Drug Delivery and Therapeutics
This research investigates the teratogenicity of SNRI (Venlafaxine) on neural tube formation in Gallus gallus domesticus (chick embryos). Fertilized eggs were exposed to two levels of Venlafaxine (500 ppm and 1000 ppm), and embryonic results were evaluated after 24 hours of incubation.
Gaurang Anil Joshi, Tejas Mahesh Sabnis, Pradeep Chaudhary   +2 more
openaire   +1 more source

Can Prenatal Ultrasound and Genetic Testing Reliably Exclude Non‐Isolated Clubfoot?

Prenatal Diagnosis, Volume 46, Issue 1, Page 30-38, January 2026.
ABSTRACT Objective The aim of this study is to evaluate the efficacy of prenatal second trimester ultrasound in diagnosing isolated congenital clubfoot and to assess the role of prenatal genetic testing. Methods We conducted a retrospective cohort study in the North‐West region of the Netherlands with prenatally suspected clubfoot between 16 and 24 ...
Jana M. de Vries, Arda Arduc, Elisabeth van Leeuwen, Maria B. Tan – Sindhunata, Peter Struijs, Melinda Witbreuk, Ingeborg H. Linskens, Eva Pajkrt   +7 more
wiley   +1 more source

Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects

Epigenetics & Chromatin, 2019
Background Neural tube defects (NTDs) are severe, common birth defects that result from failure of normal neural tube closure during early embryogenesis. Accumulating strong evidence indicates that genetic factors contribute to NTDs etiology, among them, 
Juan Yu, Lei Wang, Pei Pei, Xue Li, Jianxin Wu, Zhiyong Qiu, Juan Zhang, Ruifang Ao, Shan Wang, Ting Zhang, Jun Xie   +10 more
doaj   +1 more source