Results 41 to 50 of about 9,343 (179)

From exencephaly to anencephaly: a catastrophic continuum of neural tube defects from embryogenesis to ultrasonographic diagnosis

Journal of Perinatal Medicine
Neural tube defects (NTDs) are severe congenital anomalies arising from incomplete closure of the neural tube during early embryogenesis. Among cranial NTDs, exencephaly, acrania, and anencephaly represent a progressive developmental continuum, leading ...
Andonotopo Wiku, Bachnas Muhammad Adrianes, Dewantiningrum Julian, Pramono Mochammad Besari Adi, Sulistyowati Sri, Stanojevic Milan, Kurjak Asim   +6 more
doaj   +1 more source

Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

Cell Reports, 2017
Summary: Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates unidirectional transfer of methyl groups from the folate cycle to the methionine cycle and ...
Kit-Yi Leung, Yun Jin Pai, Qiuying Chen, Chloe Santos, Enrica Calvani, Sonia Sudiwala, Dawn Savery, Markus Ralser, Steven S. Gross, Andrew J. Copp, Nicholas D.E. Greene   +10 more
doaj   +1 more source

Global analysis of cell behavior and protein dynamics reveals region-specific roles for Shroom3 and N-cadherin during neural tube closure

eLife, 2022
Failures of neural tube closure are common and serious birth defects, yet we have a poor understanding of the interaction of genetics and cell biology during neural tube closure.
Austin T Baldwin, Juliana H Kim, Hyemin Seo, John B Wallingford   +3 more
doaj   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Noncanonical function of folate through folate receptor 1 during neural tube formation

Nature Communications
Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The mechanisms underlying NTDs and their prevention by folate remain unclear.
Olga A. Balashova, Alexios A. Panoutsopoulos, Olesya Visina, Jacob Selhub, Paul S. Knoepfler, Laura N. Borodinsky   +5 more
doaj   +1 more source

Burden of Neural Tube Defects and Their Associated Factors in Africa: A Systematic Review and Meta-Analysis

International Journal of Pediatrics, 2023
Background. Neural tube defects are a type of congenital anomaly caused by an abnormality in the development of the brain and spinal cord during embryogenesis. They cause high rates of mortality, morbidity, and lifelong disability.
Reta Wakoya, Mekbeb Afework
doaj   +1 more source

Administration of prosaposin-derived neurotrophic factor to neural tube defects facilitates regeneration and restores neurological functions

iScience, 2023
Summary: Neural tube defects (NTDs) cause fetal and pediatric deaths or lifelong neurological disabilities. No effective treatment is currently available for NTDs.
Sakirul Khan, Akihide Takeuchi, Hiroaki Nabeka, Farzana Khan, Tetsuya Shimokawa, Sota Takanezawa, Takashi Saitou, Takeshi Imamura, Tetsuya Tachibana, Akira Nishizono, Fumihiko Hamada, Seiji Matsuda   +11 more
doaj   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Potential Impact of Large‐Scale Food Fortification in Ethiopia: Coverage and Knowledge of Fortifiable Foods

Maternal &Child Nutrition, EarlyView.
Coverage of fortifiable oil, salt, and wheat flour by wealth quintiles. ABSTRACT Large‐scale food fortification (LSFF) is an effective public health measure because it may reach a large number of populations at risk using current food delivery systems.
Aregash Samuel, Ramadhani Noor, Nahom Tefera, Alemayehu Hussien, Genet Gebremedhin, Mduduzi Mbuya, Endale Amare, Meseret Woldeyohannes, Getinet Fikresilassie, Meron Girma, Alemnesh Petros, Anbissa Muleta, Bedasa Tessema, Feyissa Chala, Kaleab Baye, Arnaud Laillou, Tesfaye Chuko, Getachew Tollera, Mesay Hailu, Stanley Chitekwe, Masresha Tessema   +20 more
wiley   +1 more source

Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects

Epigenetics & Chromatin, 2019
Background Neural tube defects (NTDs) are common congenital malformations resulting in failure of the neural tube closure during early embryonic development.
Pei Pei, Xiyue cheng, Juan Yu, Jinying Shen, Xue Li, Jianxin Wu, Shan Wang, Ting Zhang   +7 more
doaj   +1 more source