Results 51 to 60 of about 134,617 (294)

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

DNA aptamers that modulate biological activity of model neurons

Molecular Therapy: Nucleic Acids
There is an urgent need for agents that promote health and regeneration of cells and tissues, specifically to treat diseases of the aging nervous system.
Jenelle Rolli, Keenan Pearson, Brandon Wilbanks, Sybil C.L. Hrstka, Andrew P. Minotti, Lorenz Studer, Arthur E. Warrington, Nathan P. Staff, L. James Maher, III   +8 more
doaj   +1 more source

Na+/Ca2+ Exchanger Inhibitors Inhibit Neurite Outgrowth in PC12 Cells

Journal of Pharmacological Sciences, 2011
.: To elucidate the role of Na+/Ca2+ exchanger (NCX) in neurite outgrowth, we investigated the effects of NCX inhibitors on neurite outgrowth in PC12 cells.
Toru Oda, Toshiaki Kume, Yasuhiko Izumi, Kumatoshi Ishihara, Hachiro Sugmimoto, Akinori Akaike   +5 more
doaj   +1 more source

Two distinct filopodia populations at the growth cone allow to sense nanotopographical extracellular matrix cues to guide neurite outgrowth. [PDF]

PLoS ONE, 2010
BACKGROUND: The process of neurite outgrowth is the initial step in producing the neuronal processes that wire the brain. Current models about neurite outgrowth have been derived from classic two-dimensional (2D) cell culture systems, which do not ...
Kyung-Jin Jang, Min Sung Kim, Daniel Feltrin, Noo Li Jeon, Kahp-Yang Suh, Olivier Pertz   +5 more
doaj   +1 more source

DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. [PDF]

, 2019
Neuronal morphology and circuitry established during early development must often be maintained over the entirety of animal lifespans. Compared with neuronal development, the mechanisms that maintain mature neuronal structures and architecture are little
Andrew D. Chisholm, Antonio Colavita, Carr, Chalfie, Chen, Chen, Chen, Coleman, Dickinson, Emoto, Finn, Hammarlund, Hayashi, Jan, Lee, Li, Li, Matter, Mukhopadhyay, Nathaniel Noblett, Nitta, Ouchi, Pan, Sanchez-Alvarez, Schmelz, Seungmee Park, Stephane Flibotte, Tank, Thorvaldsdóttir, Tony Roenspies, Toth, Wu, Yan, Yishi Jin, Zhang, Zhao Hua Ding, Zilu Wu   +36 more
core   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

Interleukin-1 beta and neurotrophin-3 synergistically promote neurite growth in vitro

Journal of Neuroinflammation, 2011
Pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) are considered to exert detrimental effects during brain trauma and in neurodegenerative disorders.
Boato Francesco, Hechler Daniel, Rosenberger Karen, Lüdecke Doreen, Peters Eva M, Nitsch Robert, Hendrix Sven   +6 more
doaj   +1 more source

Molecular mechanisms separating two axonal pathways during embryonic development of the avian optic tectum [PDF]

, 1991
During embryonic development of the avian optic tectum, retinal and tectobulbar axons form an orthogonal array of nerve processes. Growing axons of both tracts are transiently very closely apposed to each other. Despite this spatial proximity, axons from
Adler, Alvarado-Mallart, Bixby, Bixby, Bonhoeffer, Bonhoeffer, Boxberg, Bray, Cohen, Edelman, Elsdale, Goldberg, Goldberg, Halfter, Halfter, Halfter, Halfter, Halfter, Halfter, Halfter, Hamburger, Hankin, Harris, Haydon, Kapfhammer, Kapfhammer, Kapfhammer, Katz, Kroger, Kröger, Lagenaur, LaVail, Letourneau, Letourneau, Liesi, Linser, Mattson, McCobb, McLoon, O'Leary, Puelles, Rager, Raper, Rathjen, Rogers, Rosner, Sanes, Silver, Silver, Smalheiser, Thanos, Tomaselli, Vanselow, Walter, Wictorin, Zipser   +55 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

TERAHERTZ RADIATION INFLUENCE ON THE GROWING OF NEURITES [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2013
Our research was devoted to the impact of broadband pulsed THz radiation in the frequency range of 0.05 to 2 THz on the neurite growth in the sensory ganglia of 10-12-day chicken embryos.
M. V. Tsurkan, O. A. Smolyanskaya, N. G. Bryantseva   +2 more
doaj