Results 51 to 60 of about 87,065 (293)
Degenerate human nucleus pulposus cells promote neurite outgrowth in neural cells. [PDF]
PLoS ONE, 2012 Innervation of nociceptive nerve fibres into the normally aneural nucleus pulposus (NP) of the intervertebral disc (IVD) occurs during degeneration resulting in discogenic back pain.
Stephen M Richardson +5 more
doaj +1 more source
Merlin Inhibits Neurite Outgrowth in the CNS [PDF]
The Journal of Neuroscience, 2010 The neurofibromatosis type 2 gene product merlin is known to provoke gliogenic tumors as a result of its mutagenic loss. Merlin's physiological anti-mitogenic function makes it unique among its ezrin–radixin–moesin (ERM) family members. Although ERM proteins and merlin are known to be expressed in glial cells of the peripheral nervous system and CNS ...
Alexander, Schulz +5 more
openaire +2 more sources
Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]
, 2004 Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Guimond, S +17 more
core +1 more source
Transcriptional Reprogramming of Embryonic Hippocampal Neurons Underlying Enhanced Neurite Outgrowth [PDF]
, 2023 After injury to the central nervous system (CNS), neuron-intrinsic limitations and extracellular factors in the CNS milieu restrict axon growth potential. A greater understanding of the underlying mechanisms of axon growth may provide therapeutic targets
Lowell, Jeffrey
core +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai +13 more
wiley +1 more source
LLLT improves neurite outgrowth.
, 2023 Relative neurite outgrowth (% of control) after LLLT treatment for 3 days and 7 days. Data were expressed as mean ± SD; n = 3.
Poommaree Namchaiw (730766) +4 more
core +1 more source
Advanced Functional Materials, EarlyView.This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu +14 more
wiley +1 more source
Journal of Pharmacological Sciences, 2004 Adenosine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. We found that adenosine increases NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK), but decreases the duration of phosphorylation of p38 ...
Yoshikage Muroi +4 more
doaj +1 more source
Hypoxic stress enhances extension and branching of dorsal root ganglion neuronal outgrowth
JOR Spine, 2020 It has been shown that painful intervertebral discs (IVDs) were associated with a deeper innervation. However, the effect of the disc's degenerative microenvironment on neuronal outgrowth remains largely unknown.
Junxuan Ma +9 more
doaj +1 more source
Regulation of Neurite Outgrowth by Integrin Activation [PDF]
The Journal of Neuroscience, 2000 During late-embryonic development, retinal neurons lose the ability to attach and extend neurites on the extracellular matrix molecule laminin-1 (LN-1), despite the fact that they retain expression of integrin receptors for LN-1. Here we show that the developmental loss of responsiveness to LN-1 can be reversed by treatments that increase the ...
Ivins, Jonathan K +2 more
openaire +4 more sources