Results 61 to 70 of about 87,065 (293)

Neurite outgrowth analysis.

, 2018
(A) Example of neurite outgrowth experimental setup. 5 positions per line were selected and imaged every 9 minutes over a period of 3 hours. Neurite length was assessed using Fiji’s plugin mTrackJ.
Andrea Meixner (4919071), Julia Catherine Fitzgerald (4919068), David Schöndorf (4919080), Lydia Reinhardt (4919074), Michael Glatza (393601), Michela Deleidi (219439), Thomas Gasser (33499), Christine Bus (4919077), Manuela Kübler (4919065), Peter Reinhardt (327591), Christian Johannes Gloeckner (238484), Lara Marrone (4919086), Tanya Levin (4919083), Benjamin Schmid (125863), Barbara Klink (391506), Jared Sterneckert (393607)   +15 more
core   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Low-Molecular Weight Protamine Overcomes Chondroitin Sulfate Inhibition of Neural Regeneration

Frontiers in Cell and Developmental Biology, 2022
Protamine is an arginine-rich peptide that replaces histones in the DNA-protein complex during spermatogenesis. Protamine is clinically used in cardiopulmonary bypass surgery to neutralize the effects of heparin that is required during the treatment ...
Natalia Kulesskaya, Ekaterina Mugantseva, Rimante Minkeviciene, Natalia Acosta, Ari Rouhiainen, Juha Kuja-Panula, Mikhail Kislin, Sami Piirainen, Mikhail Paveliev, Heikki Rauvala   +9 more
doaj   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Fasudil Stimulates Neurite Outgrowth and Promotes Differentiation in C17.2 Neural Stem Cells by Modulating Notch Signalling but not Autophagy

Cellular Physiology and Biochemistry, 2015
Background: Neurite outgrowth is one of the important therapeutic strategies for neuronal plasticity and regeneration in neural disorders. Fasudil is a clinical medication that is used to treat subarachnoid haemorrhage (SAH) and that is beneficial for ...
Shu Chen, Ming Luo, Yuming Zhao, Yimin Zhang, Mingliang He, Wangqing Cai, Anmin Liu   +6 more
doaj   +1 more source

Neurite Outgrowth Inhibitors in Gliotic Tissue [PDF]

Neural Plasticity, 1992
Gliotic tissue is the major obstacle to axon regeneration after CNS injury. We designed tissue culture assays to search for molecules responsible for neurite outgrowth inhibition in gliotic tissue. All the inhibitory activity in injured brain tissue was located in a plasma membrane heparan-sulphate and condroitin-sulphate type-proteoglycan of apparent ...
Nieto-Sampedro, M., Bovolenta, P., Wandosell, F.   +2 more
openaire   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Biologically plausible models of neurite outgrowth [PDF]

, 2005
Publisher Summary Mathematical modeling and computer simulation are valuable tools in unraveling the complexities underlying the morphological development of neurons. The chapter describes the biologically plausible mathematical models of neurite initiation, elongation, and branching.
Kiddie, G., McLean, D., van Ooijen, A., Graham, B.   +3 more
openaire   +4 more sources