Results 1 to 10 of about 76,095 (143)

The Role of TLR4 in the Paclitaxel Effects on Neuronal Growth In Vitro [PDF]

PLoS ONE, 2013
Paclitaxel (Pac) is an antitumor agent that is widely used for treatment of solid cancers. While being effective as a chemotherapeutic agent, Pac in high doses is neurotoxic, specifically targeting sensory innervations.
Gutkin, DW, Shurin, GV, Shurin, MR, Ustinova, EE   +3 more
core   +8 more sources

A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. [PDF]

eLife, 2019
Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the ...
Clanton, Joshua A, Cronan, Mark R, Jiang, Nan, Kim, Hyeon-Jin, Luedke, Kory P, Parker, Edward D, Parrish, Jay Z, Rasmussen, Jeffrey P, Rosenberg, Marci F, Sagasti, Alvaro, Vaughan, Joshua C   +10 more
core   +3 more sources

Formation of Three-Dimensional Spheres Enhances the Neurogenic Potential of Stem Cells from Apical Papilla

Bioengineering, 2022
Cell-based neural regeneration is challenging due to the difficulty in obtaining sufficient neural stem cells with clinical applicability. Stem cells from apical papilla (SCAPs) originating from embryonic neural crests with high neurogenic potential ...
Mohammed S. Basabrain, Jialin Zhong, Haiyun Luo, Junqing Liu, Baicheng Yi, Ahmed Zaeneldin, Junhao Koh, Ting Zou, Chengfei Zhang   +8 more
doaj   +1 more source

Infectivity of Human Olfactory Neurons to SARS-CoV-2: A Link to Anosmia

Oman Medical Journal, 2021
Objectives: We sought to determine whether SARS-CoV-2 infections are associated with anosmia and if this virus infects other neuronal cells. We utilized male and female olfactory neuronal cell lines and other olfactory cell lines to determine the viral ...
Omar Bagasra, Pratima Pandey, Jessica R. Sanamandra, Jarrett M. Houston, Ewen McLean, Helmut Albrecht   +5 more
doaj   +1 more source

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells

Frontiers in Medical Technology, 2022
TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders.
Michael Rotherham, Michael Rotherham, Yasamin Moradi, Tasmin Nahar, Dominic Mosses, Dominic Mosses, Neil Telling, Alicia J. El Haj, Alicia J. El Haj   +8 more
doaj   +1 more source

Probing brain tissue microstructure with MRI: principles, challenges, and the role of multidimensional diffusion-relaxation encoding

NeuroImage, 2023
Diffusion MRI uses the random displacement of water molecules to sensitize the signal to brain microstructure and to properties such as the density and shape of cells. Microstructure modeling techniques aim to estimate these properties from acquired data
Björn Lampinen, Filip Szczepankiewicz, Jimmy Lätt, Linda Knutsson, Johan Mårtensson, Isabella M. Björkman-Burtscher, Danielle van Westen, Pia C. Sundgren, Freddy Ståhlberg, Markus Nilsson   +9 more
doaj   +1 more source

A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities

Molecular Therapy: Nucleic Acids, 2022
Polyglutamine (polyQ) diseases, including spinocerebellar ataxias and Huntington’s disease, are progressive neurodegenerative disorders caused by CAG triplet-repeat expansion in the coding regions of disease-associated genes. In this study, we found that
Shaohong Isaac Peng, Lok I. Leong, Jacquelyne Ka-Li Sun, Zhefan Stephen Chen, Hei-Man Chow, Ho Yin Edwin Chan   +5 more
doaj   +1 more source

Sphingomyelin in Human Breast Milk might be Essential for the Hippocampus Maturation

Frontiers in Bioscience-Landmark, 2022
Background: It has been established that sphingomyelin present human breast milk is useful for the brain maturation and cognitive development. At 10 days of breastfeeding the sphingomyelin content is double that present in cow’s milk and its content is ...
Elisabetta Albi, Cataldo Arcuri, Toshihide Kobayashi, Nario Tomishige, Michele Dei Cas, Rita Paroni, Paola Signorelli, Laura Cerquiglini, Stefania Troiani, Chiara Gizzi, Maria Rachele Ceccarini, Alessandra Mirarchi, Lina Cossignani, Mercedes Garcia Gil, Tommaso Beccari, Samuela Cataldi   +15 more
doaj   +1 more source

Are there roles for heterogeneous ribosomes during sleep in the rodent brain?

Frontiers in Molecular Biosciences, 2022
The regulation of mRNA translation plays an essential role in neurons, contributing to important brain functions, such as brain plasticity and memory formation. Translation is conducted by ribosomes, which at their core consist of ribosomal proteins (RPs)
Isla M. Buchanan, Trevor M. Smith, Trevor M. Smith, André P. Gerber, Julie Seibt   +4 more
doaj   +1 more source

RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons

Cells, 2021
Cell polarity is crucial for almost every cell in our body to establish distinct structural and functional domains. Polarized cells have an asymmetrical morphology and therefore their proteins need to be asymmetrically distributed to support their ...
Maite Blanco-Urrejola, Adhara Gaminde-Blasco, María Gamarra, Aida de la Cruz, Elena Vecino, Elena Alberdi, Jimena Baleriola   +6 more
doaj   +1 more source