Results 91 to 100 of about 8,012 (216)

Improved syntheses of aromatase inhibitors and neuroactive steroids efficient oxidations and reductions at key positions for bioactivity [PDF]

, 1999
An Henbest reduction, followed by the preparation of a silyl enol ether and oxidation in situ with m-CPBA has led to the neurosteroids 3[alpha]-hydroxy- and 3[alpha],21-dihydroxy-5[alpha]-pregnanolones.
Neves, André S. Campos, Melo, Maria Luisa Sá e, Moreno, Maria José S. M., Silva, Elisiário J. Tavares da, Salvador, Jorge A. R., Costa, Saul P. da, Martins, Rosa Maria L. M.   +6 more
core   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential [PDF]

, 2008
Background Factors that regulate intracellular calcium concentration are known to play a critical role in brain function and neural development, including neural plasticity and neurogenesis.
Jun Ming Wang, Roberta Diaz Brinton, EE Baulieu, NA Compagnone, E Plassart-Schiess, KW Gee, KW Gee, D Belelli, D Belelli, D Belelli, MB Herd, AM Hosie, JJ Lambert, E Cherubini, YF Wang, TS Perrot-Sinal, Y Ben-Ari, AN van den Pol, RD Brinton, MC Son, L Zhao, B Berninger, R Gniadecki, AR Means, KP Lu, M van Lookeren Campagne, K Yoshikawa, M Whitaker, R Ashworth, DF Owens, JM Wang, RD Brinton, JM Wang, JM Wang, JM Wang, J Nilsen, TW Wu, PD Henry, D Raeburn, M Son, KW Gee, KW Gee, AC Grobin, QY Liu, G Dayanithi, JJ Lambert, R Rupprecht, LD Sanford, ED Pakarinen, F Impagnatiello, ME Chavez, K Teshima, G Chapouthier, LA Blair, DF Owens, K Obrietan, K Obrietan, K Obrietan, Y Ben-Ari, R Tyzio, Y Ikeda, Y Ikeda, K Obata, E Delpire, KW Sung, AR Brooks-Kayal, KA Behringer, P Montpied, MO Poulter, IE Holopainen, F Didelon, JJ Lambert, M Rahman, R Maitra, D Maric   +74 more
core   +2 more sources

Adolescent Vitamin D Supplementation Reverses Neuroplasticity and Motivational Deficits Induced by Developmental Alcohol Exposure and Early‐Life Stress

International Journal of Developmental Neuroscience, Volume 86, Issue 1, February 2026.
Adolescent vitamin D supplementation reverses behavioural and neuroplastic impairments induced by early‐life alcohol exposure and maternal separation in rats. Postnatal ethanol exposure (PND 4–10) and maternal separation stress (PND 2–14) led to motivational deficits and altered hippocampal plasticity.
Anelise Pereira Alves, Claudia Daniele Bianco, Clarice Mariano Fernandes, Ian Carlos Hübner, Patricia S. Brocardo   +4 more
wiley   +1 more source

Divergent mechanisms of steroid inhibition in the human ρ1 GABAA receptor

Nature Communications
ρ-type γ-aminobutyric acid-A (GABAA) receptors are widely distributed in the retina and brain, and are potential drug targets for the treatment of visual, sleep and cognitive disorders.
Chen Fan, John Cowgill, Rebecca J. Howard, Erik Lindahl   +3 more
doaj   +1 more source

Dehydroepiandrosterone sulfate (DHEAS) is neuroprotective when administered either before or after injury in a focal cortical cold lesion model [PDF]

, 2006
Dehydroepiandrosterone and its sulfate (DHEAS) are sex hormone precursors that exert marked neurotrophic and/or neuroprotective activity in the central nervous system.
Dobszay B., Gábor, Farkas, Tamás, Juhász-Vedres, Gabriella, Kis, Zsolt, Párducz, Árpád, Rákos, Gabriella, Rózsa, Éva, Toldi, József, Wölfling, János   +8 more
core  

Schwann cell development, maturation and regeneration: a focus on classic and emerging intracellular signaling pathways

Neural Regeneration Research, 2017
The development, maturation and regeneration of Schwann cells (SCs), the main glial cells of the peripheral nervous system, require the coordinate and complementary interaction among several factors, signals and intracellular pathways.
Luca Franco Castelnovo, Veronica Bonalume, Simona Melfi, Marinella Ballabio, Deborah Colleoni, Valerio Magnaghi   +5 more
doaj   +1 more source

Androgenetic alopecia: a review [PDF]

, 2017
Purpose Androgenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism
Caro, Gemma, Fortuna, MARIA CATERINA, Lenzi, Andrea, Lolli, Francesca, Lombardo, Francesco, Pallotti, Francesco, Rossi, Alfredo, Sansone, Andrea   +7 more
core   +1 more source

Probing GABAA receptors with inhibitory neurosteroids [PDF]

, 2018
γ-aminobutyric acid type A receptors (GABAARs) are important components of the central nervous system and they are functionally tasked with controlling neuronal excitability.
Bright, DP, Seljeset, S, Smart, TG, Thomas, P   +3 more
core   +1 more source

Steroids in childhood epilepsy

Annals of Indian Academy of Neurology, 2006
Treatment of epileptic encephalopathies can be very challenging as most anticonvulsant drugs fail to achieve good seizure control. Steroids are disease modifying as well as anticonvulsant in these conditions.
Ramachandrannair Rajesh
doaj