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Dehydroepiandrosterone: A neuroactive steroid
The Journal of Steroid Biochemistry and Molecular Biology, 2015Dehydroepiandrosterone (DHEA) and its sulfate bound form (DHEAS) are important steroids of mainly adrenal origin. They are produced also in gonads and in the brain. Dehydroepiandrosterone easily crosses the brain-blood barrier and in part is also produced locally in the brain tissue.
Luboslav Stárka +2 more
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2014
This entry delineates the pharmacological, physiological, pathological, and therapeutic relevance of neuroactive steroids. These steroids are endogenous or synthetic compounds that can cross the blood-brain barrier and rapidly alter neuronal excitability via membrane receptors.
Morrow AL, Porcu P
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This entry delineates the pharmacological, physiological, pathological, and therapeutic relevance of neuroactive steroids. These steroids are endogenous or synthetic compounds that can cross the blood-brain barrier and rapidly alter neuronal excitability via membrane receptors.
Morrow AL, Porcu P
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Neuroactive steroids in neuropsychopharmacology
2001Steroids influence neuronal function through binding to intracellular receptors, which may act as transcription factors in the regulation of gene expression. In addition, certain so-called neuroactive steroids are potent modulators of an array of ligand-gated ion channels and of distinct G-protein-coupled receptors via nongenomic mechanisms ...
Rupprecht, R., Holsboer, F.
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Stress and neuroactive steroids
2001The discovery that the endogenous steroid derivatives 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone, or 3 alpha,5 alpha-TH PROG) and 3 alpha,21-dihydroxy-5 alpha-pregnan-20-one (allotetrahydrodeoxycorticosterone, or 3 alpha,5 alpha-TH DOC) elicit marked anxiolytic and anti-stress effects and selectively facilitate gamma-aminobutyric acid ...
Barbaccia ML +3 more
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Neuroactive steroids with perfluorobenzoyl group
Steroids, 2012During an initial study in searching for the alternative derivatives suitable for photolabeling of neuroactive steroids, perfluorobenzoates and perfluorobenzamides in position 17 of 5β-androstan-3α-ol were synthesized from the corresponding 17-hydroxy and 17-amino derivatives. After transformation into glutamates or sulfates, 17α-epimers had comparable
Ivan, Cerný +5 more
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Steroids, neuroactive steroids and neurosteroids in psychopathology
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2005The term "neurosteroid" (NS) was introduced by Baulieu in 1981 to name a steroid hormone, dehydroepiandrosterone sulfate (DHEAS), that was found at high levels in the brain long after gonadectomy and adrenalectomy, and shown later to be synthetized by the brain.
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Neuropsychopharmacological properties of neuroactive steroids
Steroids, 1999In addition to the well-known genomic effects of steroid molecules via intracellular steroid receptors, certain steroids rapidly alter neuronal excitability through interaction with neurotransmitter-gated ion channels. Several of these steroids accumulate in the brain after local synthesis or after metabolism of adrenal steroids.
R, Rupprecht, F, Holsboer
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Azido analogs of neuroactive steroids
Steroids, 2011Analogs of pregnanolone (3α-hydroxy-5β-pregnan-20-one), modified in position 17 were prepared. Compounds with 20-keto pregnane side chain replaced completely by azide (17α- and 17β-azido-5β-androstan-3α-ol), compounds with its part replaced (20-azido-21-nor-5β-pregnan-3α-ol), and compounds with keto group only replaced ((20R)- and (20S)-20-azido-5β ...
Lukáš, Vidrna +6 more
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Neuroactive steroids and the constraint of memory
European Journal of Neuroscience, 1999AbstractDifferent normo‐ and pathophysiological conditions are associated with large variations in plasma and brain concentrations of neuroactive steroids. In an attempt to specify the possible role of these steroids in memory processes, we examined the ability of pregnanolone, a positive modulator of the γ‐aminobutyric acid type A (GABAA) receptor ...
L A, Bruins Slot +2 more
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Neuroactive Properties of Reproductive Steroids
Headache: The Journal of Head and Face Pain, 2007Migraine is 3 times more common in postpubertal women than in men. Migraine is frequently exacerbated perimenstrually and commonly occurs exclusively at that time. It is often benefited by pregnancy and menopause. Estrogen withdrawal has been implicated as a mechanism for triggering migraines.
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