Results 161 to 170 of about 4,357 (193)

Insight into the Mechanism of Action of Neuroactive Steroids

Molecular Pharmacology, 2004
Rho(1) receptor-channels (rho(1)Rs) are GABA-gated chloride channels that exhibit slow kinetics, little desensitization, and inert pharmacology to most anesthetics, except for neuroactive steroids (NSs). NSs differentially modulate rho(1)Rs dependent on the steric arrangement of the hydrogen atom at the fifth carbon position.
Kendall D W, Morris, Jahanshah, Amin
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Social isolation stress and neuroactive steroids

European Neuropsychopharmacology, 2007
Social isolation of rats immediately after weaning is associated to a reduction in the cerebrocortical and plasma concentrations of progesterone and its metabolites 3alpha,5alpha-TH PROG and 3alpha,5alpha-THDOC. Although we found that the basal plasma concentration of adrenocorticotropic hormone in isolated rats was slightly decreased compared with ...
SERRA, MARIANGELA, SANNA, ENRICO, MOSTALLINO MC, BIGGIO G.   +3 more
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Pharmacology of Endogenous Neuroactive Steroids

Critical Reviews? in Neurobiology, 2004
Neuroactive steroids are potent endogenous neuromodulators with rapid actions in the central nervous system. Neuroactive steroids have been claimed to have specific physiological roles in normal or pathological brain function. This article reviews the emerging evidence that progesterone-, deoxycorticosterone-, and testosterone-derived endogenous ...
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Neuroactive Steroid Actions at the GABAA Receptor

Hormones and Behavior, 1994
Neuroactive steroids are a new class of steroids that do not interact with any of the classical cytosolic hormonal steroid receptors. The most well-documented examples are those that interact with the gamma-aminobutyric acidA (GABAA) receptor/chloride channel complex in the central nervous system.
N C, Lan, K W, Gee
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The neuropsychopharmacological potential of neuroactive steroids

Journal of Psychiatric Research, 1997
In addition to the well-known genomic effects of steroid molecules via intracellular steroid receptors, certain steroids rapidly alter neuronal excitability through interaction with neurotransmitter-gated ion channels. Several of these steroids accumulate in the brain after local synthesis or after metabolism of adrenal steroids.
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Neuroactive Steroids as Endogenous Modulators of Anxiety

Current Pharmaceutical Design, 2008
In the past decades considerable evidence has emerged that certain so called neuroactive steroids not only act as transcription factors in the regulation of gene expression but may also alter neuronal excitability through interaction with specific neurotransmitter receptors such as gamma-aminobutyric acid type A (GABA(A)), N-methyl-D-aspartate (NMDA ...
Daniela, Eser, Thomas C, Baghai, Cornelius, Schüle, Caroline, Nothdurfter, Rainer, Rupprecht   +4 more
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Neuroactive Steroids

2023
C. Fernando Valenzuela, Samantha Varela
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Neuroactive Steroids in Brain and Relevance to Mood

2008
Depression and anxiety often affect women in relation to reproductive events like menarche, premenstrual periods, post-partum and perimenopause. A prominent example of the interaction between mood, neuroactive-steroids and the GABA system is premenstrual dysphoric disorder (PMDD). Severe premenstrual negative mood symptoms occur in 3–8% of women.
Bäckström, T., Andréen, L., Bixo, M., Björn, I., Fernández, G., Johansson, I.-M., Lundgren, P., Löfgren, M., Nyberg, S., Ragagnin, G., Poromaa-Sundström, I., Strömberg, J., van Broekhoven, F., van Wingen, G., Wang, M.   +14 more
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Neuroactive Steroids and Depression

2018
Neuroactive steroids are metabolites of gonadal steroids that act on the brain through traditional neurotransmitter mechanisms. The best studied is allopregnanolone, a metabolite of progesterone that is a potent GABAA receptor modulator. This article will discuss the evidence that relative neuroactive steroid deficiency may be a mechanism that ...
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Synthetic neuroactive steroids.

Neuro endocrinology letters
This review discusses the topic of synthetic neuroactive steroids. A brief introduction to the mode of action of neuroactive steroids is followed by a short overview of the best-known synthetic neuroactive steroids used in clinical practice and the reasons for their withdrawal from the market.
Štefan, Alušík, Zoltán, Paluch, Dagmar, Kalátová   +2 more
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