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The neuropsychopharmacological potential of neuroactive steroids
Journal of Psychiatric Research, 1997In addition to the well-known genomic effects of steroid molecules via intracellular steroid receptors, certain steroids rapidly alter neuronal excitability through interaction with neurotransmitter-gated ion channels. Several of these steroids accumulate in the brain after local synthesis or after metabolism of adrenal steroids.
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Synthetic neuroactive steroids.
Neuro endocrinology lettersThis review discusses the topic of synthetic neuroactive steroids. A brief introduction to the mode of action of neuroactive steroids is followed by a short overview of the best-known synthetic neuroactive steroids used in clinical practice and the reasons for their withdrawal from the market.
Štefan, Alušík +2 more
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NEUROACTIVE STEROIDS, RELAXATION, AND SEIZURE CONTROL
International Journal of Neuroscience, 2003Neuroactive steroids alter the excitability of membrane-bound receptors in the nervous system and have a modulatory role in the stress response and in epileptogenic activity. These changes can be detected in brain as well as in plasma. The resulting rapid (
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Neuroactive Steroids and Depression
2018Neuroactive steroids are metabolites of gonadal steroids that act on the brain through traditional neurotransmitter mechanisms. The best studied is allopregnanolone, a metabolite of progesterone that is a potent GABAA receptor modulator. This article will discuss the evidence that relative neuroactive steroid deficiency may be a mechanism that ...
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[Neuroactive steroid and stress response].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2002Dehydroepiandrosterone sulfate (DHEAS), a neuroactive steroid, has been demonstrated to bind to sigma 1 receptors, and it has antidepressive effects in the forced swimming test. We used the conditioned fear stress, which is useful for investigating the pathogenesis of mood disorders.
T, Nagai +3 more
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