Results 71 to 80 of about 8,012 (216)

Behavioral effects of triazolam and pregnanolone combinations: reinforcing and sedative-motor effects in female rhesus monkeys

Frontiers in Psychiatry, 2023
IntroductionBenzodiazepines (BZs) are prescribed as anxiolytics, but their use is limited by side effects including abuse liability and daytime drowsiness.
Jemma E. Cook, Donna M. Platt, Daniela Rüedi-Bettschen, James K. Rowlett   +3 more
doaj   +1 more source

Lipidomics of human umbilical cord serum : identification of unique sterol sulfates [PDF]

, 2017
Aim: There are currently limited lipidomics data for human umbilical cord blood. Therefore, the lipidomes of cord sera from six newborns and sera from six nonpregnant females were compared.
Knip, Jan Mikael, Siljander, Heli Tuija Annika, Wood, Paul   +2 more
core   +1 more source

Neuroactive steroids: focus on human brain

Neuroscience, 2011
Studies in experimental animals have revealed important roles of neuroactive steroids in the control of central nervous system functions during physiological and pathological conditions, suggesting that they may represent good candidates for the development of neuroprotective strategies for neurodegenerative and psychiatric disorders.
Melcangi R, PANZICA, Giancarlo, Garcia Segura LM   +2 more
openaire   +4 more sources

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Progesterone - new therapy in mild carpal tunnel syndrome? Study design of a randomized clinical trial for local therapy [PDF]

, 2010
Background Local corticosteroid injection for carpal tunnel syndrome (CTS) provides greater clinical improvement in symptoms one month after injection compared to placebo but significant symptom relief beyond one month has not been demonstrated and the ...
Paolo Milani, Mauro Mondelli, Federica Ginanneschi, Riccardo Mazzocchio, Alessandro Rossi   +4 more
core   +2 more sources

Molecular Mechanism of Mulberrin Regulating Lipid Metabolism Homeostasis Based on the Gut–Liver Axis Fiaf/AMPK Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
The molecular mechanism for mulberrin regulating lipid metabolism homeostasis. ABSTRACT Lipid metabolism disorders and the induced metabolic diseases have risen to become one of the primary public health issues. Our preliminary experimental results confirmed that mulberry leaf flavonoid extract exhibited efficacy in lipid metabolism regulation; the ...
Qian Li, Daorui Pang, Erna Li, Dongxu Xing, Fan Liu, Li Wang, Yuxiao Zou   +6 more
wiley   +1 more source

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Frontiers in Cellular Neuroscience
The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological ...
Keiko Takasu, Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Koichi Ogawa   +7 more
doaj   +1 more source

The effect of neuroactive steroids in sex differences in the developmental neurotoxicity of the anaesthetic

Clinical and Translational Discovery, 2022
The rapid growth of the number of surgical cases in the world has brought opportunities and challenges to the development of anaesthesia. Modern anaesthesia technology provides safe and effective anaesthesia for hundreds of millions of surgical ...
Ningning Li, Ruilou Zhu, Shuang Zeng, Ningning Fu, Jiaqiang Zhang   +4 more
doaj   +1 more source

Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons [PDF]

, 2006
Aminoglutethimide is a clinically available drug that suppresses steroid biosynthesis by inhibiting enzymes such as cytochrome P450scc and aromatase. Because several members of neurosteroids regulate glutamate receptors, we investigated the effect of ...
Hisashi Shirakawa, Hiroshi Katsuki, Toshiaki Kume, Shuji Kaneko, Akinori Akaike, ALSHOWAIER, BASTIDA, COIRINI, DI SALLE, FOSTER, FUJIMOTO, GUARNERI, HOLMES, IRWIN, KATSUKI, KIMONIDES, KURATA, MARAGAKIS, MATTSON, MELDRUM, MELLON, MILLER, MILLER, NEDERGAARD, NISHIZAWA, PARK-CHUNG, REDDY, ROBEL, SALHANICK, SHIRAKAWA, SHIRAKAWA, UNGER, VEIGA, WEAVER, WEAVER, WEAVER, WU, YAGHOUBI, ZWAIN   +38 more
core   +2 more sources

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source