Results 81 to 90 of about 8,012 (216)

The major brain cholesterol metabolite 24(s)-hydroxycholesterol is a potent allosteric modulator of N-methyl-d-aspartate receptors [PDF]

, 2013
N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that are critical to the regulation of excitatory synaptic function in the CNS.
Belfort, Gabriel M, Chow, Brian Y, Crawford, Devon C, Doherty, James J, Hammond, Rebecca S, Izumi, Yukitoshi, Linsenbardt, Andrew J, Mennerick, Steven J, Paul, Steven M, Robichaud, Albert J, Shu, Hong-Jin, Zorumski, Charles F   +11 more
core   +2 more sources

Therapeutic Potential of Fecal Microbiota Transplantation for Male Sexual Dysfunction: Evidence and Clinical Perspectives

Microbiota Medicine Research, Volume 1, Issue 1, Page 12-24, March 2026.
ABSTRACT Fecal microbiota transplantation (FMT), a microbiome‐based therapy, shows potential in treating male sexual dysfunction. Research into the influence of FMT on male sexual function has recently garnered increasing attention. This review aims to explore the impact of FMT on male sexual function and the underlying mechanisms, and to analyze the ...
Junyi Chen, Chenfeng Bu, Xia Li, Lei Wu, Xingxiang He   +4 more
wiley   +1 more source

Beyond the HPA axis: progesterone-derived neuroactive steroids in human stress and emotion

Frontiers in Endocrinology, 2011
Stress and social isolation are well-known risk factors for psychopathology. However, more research is needed as to the physiological mechanisms by which social support buffers the impacts of stress. Research in animal models suggests important roles for
Michelle eWirth
doaj   +1 more source

Safety and efficacy of zuranolone in Japanese adults with major depressive disorder: An open‐label, repeated‐treatment part of a Phase 3 clinical trial

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Aim To evaluate the safety and tolerability of repeating 14‐day treatment with zuranolone (30 mg) followed by a 6‐week follow‐up period (one treatment cycle) for a maximum of six treatment cycles in Japanese participants with major depressive disorder. Methods This multicenter Phase 3 study was conducted in two parts (70 sites; Japan).
Masaki Kato, Kazuyuki Nakagome, Takamichi Baba, Takuhiro Sonoyama, Hiroki Fukuju, Ryosuke Shimizu, Juan Carlos Gomez, Tomoko Motomiya, Takeshi Inoue   +8 more
wiley   +1 more source

Position paper: Rapid responses to steroids: current status and future prospects. [PDF]

, 2010
Steroids exert their actions through several pathways. The classical genomic pathway, which involves binding of steroids to receptors and subsequent modulation of gene expression, is well characterized.
Baldi, Elisabetta, Harvey, Brian J, Nadal, Angel, Norman, Anthony, Wehling, Martin, Wendler, Alexandra   +5 more
core   +1 more source

Composition, Techno‐Functional Properties, and Biological Potential of Velvet and African Yam Beans as Plant Protein Sources

Sustainable Food Proteins, Volume 4, Issue 1, March 2026.
Graphical Overview of Protein quality characterization of velvet and African yam beans. ABSTRACT The increasing demand for plant‐based foods has intensified research in alternative protein sources. This study assessed the chemical composition, functional properties, and biological qualities of velvet bean (VB) and African yam bean (AYB) flours to ...
Chiemeziem Adanma Obike, Paul Ndubuisi Anyiam, Chinedum Uche Emelike, Emmanuel Nnaemeka Uhuo, Solomon Fanyam Igbazenda   +4 more
wiley   +1 more source

Increased motor-impairing effects of the neuroactive steroid pregnanolone in mice with targeted inactivation of the GABAA receptor gamma2 subunit in the cerebellum

Frontiers in Pharmacology, 2016
Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABAA receptors. In recombinant receptors and genetic mouse models their actions depend on the alpha, beta and delta subunits of the receptor,
Elli Leppä, Anni-Maija Tuulikki Linden, M. Isabel Aller, Peer Wulff, Olga Vekovischeva, Bernhard Lüscher, Hartmut Lüddens, William Wisden, Esa R Korpi   +8 more
doaj   +1 more source

Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress Vulnerability

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Low/brief glucocorticoid (GC) elevations can enhance mitochondrial output (↑ oxygen consumption rate, OCR; ↑ mitochondrial membrane potential, ΔΨm) and Ca2+ buffering, in part via glucocorticoid receptor (GR) trafficking to mitochondria in complexes with Bcl2 and Bag1.
Paweł Hanus, Dorota Frydecka, Michał Ślęzak   +2 more
wiley   +1 more source

Finasteride withdrawal induces anxiety‐like behavior and novelty avoidance in adult male rats

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract Finasteride, an inhibitor of the enzyme 5alpha‐reductase, prescribed for benign prostatic hyperplasia and androgenetic alopecia, induces a wide variety of side effects during treatment and upon withdrawal, like sexual dysfunction and cognitive and psychological disorders, inducing the so‐called post‐finasteride syndrome (PFS).
Lucia Cioffi, Silvia Diviccaro, Gabriela Chrostek, Francesco Paolo Ulloa Severino, Silvia Giatti, Diego Scheggia, Roberto Cosimo Melcangi   +6 more
wiley   +1 more source

Psychopharmacologic and behavioral effects of neurosteroids

Psychiatry and Clinical Psychopharmacology, 2021
Steroids are known to act via genomic mechanism by binding to their own intracellular receptors. In addition to the steroids which are synthesized in the endocrine organs and able to easily cross to the brain, some steroids have been reported to be ...
Şükrü Kartalcı, Ertuğrul Eşel
doaj