Results 31 to 40 of about 155 (99)

Epigenetic clock and methylation studies in elephants

Aging Cell, Volume 20, Issue 7, July 2021., 2021
DNA methylation aging clocks for African and Asian elephants. Some of these clocks apply to humans as well. Parts of the graphic were created by Hollis Burbank‐Hammerlund, Sandra Oviedo, and BioRender.com. Abstract Age‐associated DNA‐methylation profiles have been used successfully to develop highly accurate biomarkers of age ("epigenetic clocks") in ...
Natalia A. Prado, Janine L. Brown, Joseph A. Zoller, Amin Haghani, Mingjia Yao, Lora R. Bagryanova, Michael G. Campana, Jesús E. Maldonado, Ken Raj, Dennis Schmitt, Todd R. Robeck, Steve Horvath   +11 more
wiley   +1 more source

The potential of MLC901 (NeuroAiD II™), a traditional Chinese medicine

Neuroscience Research Notes, 2019
Stroke, also known as cerebral ischemia, is a common neurological disease. The therapeutic potential of MLC901 (NeuroAiD II™) has been reported in clinical trials on traumatic brain injury as well as in animal and cell models. MLC901 reduced the infarction size, ischemia-induced neurological deficits and pro-inflammatory infiltration of phagocyte.
Suhua Huang, Mingxia Lin, Xiaowei Pan, Qiwen Tan, Kai-Leng Tan   +4 more
openaire   +2 more sources

HIV and Proteomics: What We Have Learned from High Throughput Studies

PROTEOMICS – Clinical Applications, Volume 15, Issue 1, January 2021., 2021
Abstract The accelerated development of technology over the last three decades has driven biological sciences to high‐throughput profiling experiments, now broadly referred to as systems biology. The unprecedented improvement of analytical instrumentation has opened new avenues for more complex experimental designs and expands the knowledge in genomics,
Kinga Grabowska, Emma Harwood, Pawel Ciborowski   +2 more
wiley   +1 more source

Microglial Activation and Neurological Symptoms in the SIV Model of NeuroAIDS: Association of MHC-II and MMP-9 Expression with Behavioral Deficits and Evoked Potential Changes

Neurobiology of Disease, 1999
HIV-1 causes cognitive and motor deficits and HIV encephalitis (HIVE) in a significant proportion of AIDS patients. Neurological impairment and HIVE are thought to result from release of cytokines and other harmful substances from infected, activated microglia.
Nancy E.J. Berman, Joanne K. Marcario, Chi Yong, Ravi Raghavan, Leigh A.M. Raymond, Sanjay V. Joag, Opendra Narayan, Paul D. Cheney   +7 more
openaire   +3 more sources

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, Volume 310, Issue 6, June 2025.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian, Michael T. Cook, Cécile A. Dreiss   +2 more
wiley   +1 more source

Nanotechnology Approaches for Prevention and Treatment of Chemotherapy‐Induced Neurotoxicity, Neuropathy, and Cardiomyopathy in Breast and Ovarian Cancer Survivors

Small, Volume 20, Issue 41, October 10, 2024.
Advancements in nanomedicine have led to great potential for improving the fundamental flaws in chemotherapeutics for breast and ovarian cancer treatment. Many women who survive these impactful diseases have reduced quality of life due to off‐target effects from chemotherapy.
Sarah Nevins, Callan D. McLoughlin, Alfredo Oliveros, Joshua B. Stein, Mohammad Abdur Rashid, Yannan Hou, Mi‐Hyeon Jang, Ki‐Bum Lee   +7 more
wiley   +1 more source

Blood–brain barrier disruption in dementia: Nano‐solutions as new treatment options

European Journal of Neuroscience, Volume 59, Issue 6, Page 1359-1385, March 2024.
A brief overview of this review showing the formulation of a nanoparticle, a graphical representation of the BBB and the targeted effect of nanoparticles within the brain. Created using BioRender. Abstract Candidate drugs targeting the central nervous system (CNS) demonstrate extremely low clinical success rates, with more than 98% of potential ...
Ceinwyn G. Cooper, Konstantinos N. Kafetzis, Adjanie Patabendige, Aristides D. Tagalakis   +3 more
wiley   +1 more source

The relationship between HIV‐1 neuroinflammation, neurocognitive impairment and encephalitis pathology: A systematic review of studies investigating post‐mortem brain tissue

Reviews in Medical Virology, Volume 34, Issue 1, January 2024.
Abstract The activities of HIV‐1 in the central nervous system (CNS) are responsible for a dysregulated neuroinflammatory response and the subsequent development of HIV‐associated neurocognitive disorders (HAND). The use of post‐mortem human brain tissue is pivotal for studying the neuroimmune mechanisms of CNS HIV infection.
Monray Edward Williams, Petrus J. W. Naudé   +1 more
wiley   +1 more source

The NeuroAiD II (MLC901) in vascular cognitive impairment study (NEURITES) for the NEURITE investigators

Cerebrovascular Diseases, 2013
Background: A substantial proportion of patients after nondisabling stroke are cognitively impaired compared to age- and education-matched community-dwelling controls. Moreover, poststroke patients who have 'vascular cognitive impairment no dementia' (VCIND) of moderate severity have a high risk of incident dementia, dependency and death.
Chen, C.L.H., Ikram, K., Anqi, Q., Yin, W.T., Chen, A., Venketasubramanian, N.   +5 more
openaire   +1 more source

Effects of morphine and NeuroAid on the expression levels of GluN2A and GluN3A in the hippocampus and striatum of rats. [PDF]

Iran J Basic Med Sci, 2021
Heshmatzad K, Nasehi M, Vaseghi S.
europepmc   +1 more source