Results 51 to 60 of about 30,473 (233)

Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke

Advanced Science, EarlyView.
6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li, Xuyi Chen, Haiming Fan, Xue Xue   +12 more
wiley   +1 more source

TGF-β promotes survival on mesencephalic dopaminergic neurons in cooperation with Shh and FGF-8

Neurobiology of Disease, 2004
Impaired neuronal survival is a key event in the development of degenerative diseases, such as Parkinson's disease (PD). Here we show that transforming growth factor beta (TGF-β) acts directly on rat E14 midbrain dopaminergic neurons in vitro, its ...
Eleni Roussa, Lilla M Farkas, Kerstin Krieglstein   +2 more
doaj   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Exploring the Link Between the Gut Microbiota and Epigenetic Factors in Anorexia Nervosa

Brain and Behavior
Objective Anorexia nervosa (AN) is an often chronic eating disorder that involves genetic, neurohormonal, and epigenetic factors along with key contributions from the microbiota–gut–brain axis.
N. M. Korten, A. C. Thelen, C. Voelz, C. Beyer, J. Seitz, S. Trinh, L. Blischke   +6 more
doaj   +1 more source

TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells

Stem Cells International, 2016
TBX3 is a member of the T-box transcription factor family and is involved in the core pluripotency network. Despite this role in the pluripotency network, its contribution to the reprogramming process during the generation of human induced pluripotent ...
Moritz Klingenstein, Stefanie Raab, Kevin Achberger, Alexander Kleger, Stefan Liebau, Leonhard Linta   +5 more
doaj   +1 more source

Dopamine Modulates Homeostatic Excitatory Synaptic Plasticity of Immature Dentate Granule Cells in Entorhino-Hippocampal Slice Cultures

Frontiers in Molecular Neuroscience, 2018
Homeostatic plasticity mechanisms maintain neurons in a stable state. To what extent these mechanisms are relevant during the structural and functional maturation of neural tissue is poorly understood.
Andreas Strehl, Christos Galanis, Tijana Radic, Stephan Wolfgang Schwarzacher, Thomas Deller, Andreas Vlachos, Andreas Vlachos   +6 more
doaj   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

Effectiveness of Incorporating Animated Drawings in PowerPoint Presentations for Teaching Neuroanatomy to First-phase MBBS Students

National Journal of Clinical Anatomy
Background: Using traditional PowerPoint (tPPT) as a teaching tool for cross-sections in neuroanatomy can limit interactive engagement and the depth of spatial understanding needed for complex anatomical structures.
B. R. Chaithra Rao, B. Asha, S. V. Uma
doaj   +1 more source

Impact of Abdominoperineal Resection on Postoperative Male Sexual Function After Minimally Invasive Rectal Cancer Surgery: A Subgroup Analysis From the LANDMARC Study

Annals of Gastroenterological Surgery, EarlyView.
Abdominoperineal resection (APR) after minimally invasive rectal cancer surgery was associated with significantly higher rates of erectile and early ejaculatory dysfunction compared with anal‐sparing surgery. Although ejaculatory function showed partial recovery over time, erectile dysfunction persisted up to 12 months postoperatively.
Taiki Kajiwara, Shinobu Ohnuma, Michiaki Unno, Masakatsu Numata, Tomohiro Yamaguchi, Koya Hida, Tomonori Akagi, Suguru Hasegawa, Akio Shiomi, Ryo Inada, Manabu Shiozawa, Keisuke Kazama, Masanori Hotchi, Masahiko Watanabe, Takeshi Naitoh   +14 more
wiley   +1 more source

Sympathetic tales: subdivisons of the autonomic nervous system and the impact of developmental studies

Neural Development, 2018
Remarkable progress in a range of biomedical disciplines has promoted the understanding of the cellular components of the autonomic nervous system and their differentiation during development to a critical level.
Uwe Ernsberger, Hermann Rohrer
doaj   +1 more source