Results 11 to 20 of about 268,028 (214)

Chromosome 1p36 candidate gene ZNF436 predicts the prognosis of neuroblastoma: a bioinformatic analysis

Italian Journal of Pediatrics, 2023
Background Genetic 1p deletion is reported in 30% of all neuroblastoma and is associated with the unfavorable prognosis of neuroblastoma. The expressions and prognosis of 1p candidate genes in neuroblastoma are unclear.
Haiwei Wang, Xinrui Wang, Liangpu Xu
doaj   +1 more source

TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma

BMC Genomic Data, 2022
Background TP53 is rarely mutated in paediatric neuroblastoma. The prognosis of TP53 and TP53-associated genes in paediatric neuroblastoma is unclear.
Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang   +3 more
doaj   +1 more source

Age related gene DST represents an independent prognostic factor for MYCN non-amplified neuroblastoma

BMC Pediatrics, 2021
Background MYCN amplification and age are two critical prognostic factors of pediatric neuroblastoma. Previously, we had revealed the prognosis of MYCN target genes.
Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang, Hua Cao   +4 more
doaj   +1 more source

MYCN Function in Neuroblastoma Development

Frontiers in Oncology, 2021
Dysregulated expression of the transcription factor MYCN is frequently detected in nervous system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a single oncogenic driver inducing neoplastic transformation in neural crest ...
Jörg Otte, Cecilia Dyberg, Adena Pepich, J. Johnsen   +3 more
semanticscholar   +1 more source

Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma

Nature Communications, 2021
The ability to utilize preclinical models to predict the clinical toxicity of chimeric antigen receptor (CAR) T cells in solid tumors is tenuous, thereby necessitating the development and evaluation of gated systems.
B. Moghimi, Sakunthala Muthugounder, S. Jambon, Rachelle Tibbetts, Long T. Hung, H. Bassiri, M. Hogarty, D. Barrett, H. Shimada, S. Asgharzadeh   +9 more
semanticscholar   +1 more source

MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis

Cancer Research, 2021
The study shows how MYCN increases intracellular iron levels and subsequent GSH pathway activity and demonstrates the antitumor activity of FDA-approved SAS and auranofin in patient-derived xenograft models of MYCN-amplified neuroblastoma.
K. Floros, Jinyang Cai, Sheeba Jacob, Richard I. J. Kurupi, Carter K. Fairchild, Mayuri Shende, Colin M. Coon, Krista M. Powell, B. Belvin, Bin Hu, Madhavi Puchalapalli, S. Ramamoorthy, Kimberly Swift, J. Lewis, M. Dozmorov, J. Glod, J. Koblinski, S. Boikos, A. Faber   +18 more
semanticscholar   +1 more source

CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis

Journal of Experimental & Clinical Cancer Research, 2023
Background The repressor element-1 silencing transcription factor (REST), a master transcriptional repressor, is essential for maintenance, self-renewal, and differentiation in neuroblastoma.
Janardhan Keshav Karapurkar, Min-Seong Kim, Jencia Carminha Colaco, Bharathi Suresh, Neha Sarodaya, Dong-Ho Kim, Chang-Hwan Park, Seok-Ho Hong, Kye-Seong Kim, Suresh Ramakrishna   +9 more
doaj   +1 more source

Silencing E3 Ubiqutin ligase ITCH as a potential therapy to enhance chemotherapy efficacy in p53 mutant neuroblastoma cells [PDF]

, 2020
P53 mutations are responsible for drug-resistance of tumour cells which impacts on the efficacy of treatment. Alternative tumour suppressor pathways need to be explored to treat p53- deficient tumours.
Hart, Stephen L, Meng, Jinhong, Tagalakis, Aristides D   +2 more
core   +2 more sources

Prognostic analysis of E2F transcription factors E2F1 and E2F3 in four independent pediatric neuroblastoma cohorts

BMC Pediatrics, 2022
Background Previously, we had analyzed the prognosis of E2F transcription factors across adult tumor types. However, the expressions and prognosis of E2F transcription factors in pediatric neuroblastoma have not yet been fully studied.
Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang   +3 more
doaj   +1 more source

Autophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors

Cancer Cell International, 2018
Background A growing field of evidence suggests the involvement of oncogenic receptor tyrosine kinases (RTKs) in cell transformation. Deregulated activity of RTKs in tumors can determine disease progression and therapeutic responses in several types of ...
Sanja Aveic, Marcella Pantile, Pierfrancesco Polo, Viktoryia Sidarovich, Marilena De Mariano, Alessandro Quattrone, Luca Longo, Gian Paolo Tonini   +7 more
doaj   +1 more source