P(VDF-TrFE)/BaTiO3 nanoparticle composite films mediate piezoelectric stimulation and promote differentiation of SH-SY5Y neuroblastoma cells [PDF]
Advanced Healthcare Materials, 5(14): 1808-1820 (2016), 2022 Poly(vinylidene fluoride-trifluoroethylene, P(VDF-TrFE)) and P(VDF-TrFE)/barium titanate nanoparticle (BTNP) films are prepared and tested as substrates for neuronal stimulation through direct piezoelectric effect. Films are characterized in terms of surface, mechanical, and piezoelectric features before in vitro testing on SH-SY5Y cells. In particular,
arxiv +1 more source
Molecular targeting therapies for neuroblastoma: Progress and challenges
Medicinal research reviews (Print), 2020 There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is the most common pediatric solid tumor, and accounts for ~15% of childhood cancer‐related mortality.
Atif Zafar +8 more
semanticscholar +1 more source
Generalized inverse-Gaussian frailty models with application to TARGET neuroblastoma data [PDF]
Annals of the Institute of Statistical Mathematics (2021), 2020 A new class of survival frailty models based on the Generalized Inverse-Gaussian (GIG) distributions is proposed. We show that the GIG frailty models are flexible and mathematically convenient like the popular gamma frailty model. Furthermore, our proposed class is robust and does not present some computational issues experienced by the gamma model. By
arxiv +1 more source
Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell
Science Advances, 2021 Comparisons of neuroblastoma cells and relevant normal adrenal cells reveal a uniform cell state that characterizes neuroblastoma. Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest.
Gerda Kildisiute +38 more
semanticscholar +1 more source
Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression. [PDF]
, 2016 BackgroundNovel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition with the novel MEK1/2 inhibitor binimetinib would be effective in neuroblastoma preclinical models ...
Liu, Yin +4 more
core +2 more sources
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome
Nature Communications, 2021 Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas (n = 760) and characterize its features ...
S. Hartlieb +29 more
semanticscholar +1 more source
Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells [PDF]
, 2009 BACKGROUND: Chemoresistance acquisition may influence cancer cell biology. Here, bioinformatics analysis of gene expression data was used to identify chemoresistance-associated changes in neuroblastoma biology.
Barth, Susanne +10 more
core +6 more sources
RTEL1 gene polymorphisms and neuroblastoma risk in Chinese children
BMC Cancer, 2023 Background Neuroblastoma, a neuroendocrine tumor originating from the sympathetic ganglia, is one of the most common malignancies in childhood. RTEL1 is critical in many fundamental cellular processes, such as DNA replication, DNA damage repair, genomic ...
Ting Zhang +5 more
doaj +1 more source
Targeting tachykinin receptors in neuroblastoma [PDF]
, 2016 Neuroblastoma is the most common extracranial tumor in children. Despite aggressive multimodal treatment, high-risk neuroblastoma remains a clinical challenge with survival rates below 50%.
Althoff, Kristina +14 more
core +3 more sources
Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours
BMC Cancer, 2019 Background Neuroblastoma (NB) is a paediatric tumour of the sympathetic nervous system. Half of all cases are defined high-risk with an overall survival less than 40% at 5 years from diagnosis.
P. Fusco +13 more
doaj +1 more source