Results 91 to 100 of about 271,126 (314)

Mitochondria in Neurodegeneration [PDF]

, 2011
Many neurodegenerative diseases demonstrate abnormal mitochondrial morphology and biochemical dysfunction. Alterations are often systemic rather than brain-limited. Mitochondrial dysfunction may arise as a consequence of abnormal mitochondrial DNA, mutated nuclear proteins that interact directly or indirectly with mitochondria, or through unknown ...
E, Lezi, Russell H, Swerdlow
openaire   +2 more sources

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Inactivation of NLRP3 inflammasome by dephosphorylation at Serine 658 alleviates glial inflammation in the mouse model of Parkinson’s disease

Molecular Neurodegeneration
Background Parkinson’s disease (PD) is a leading neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, contributing to considerable disability worldwide.
Rong-Xin Zhu, Rui-Xue Han, Yue-Han Chen, Lei Huang, Ting Liu, Jingwei Jiang, Cong Wang, Lei Cao, Yang Liu, Ming Lu   +9 more
doaj   +1 more source

Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?

, 2021
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly due to an arterial blockage in a specific region of the brain.
Lin Kooi Ong, Ong, Lin Kooi, Shannon M. Stuckey, Lyndsey E. Collins-Praino, Collins-Praino, Lyndsey E., Stuckey, Shannon M., Renée J. Turner, Turner, Renee J.   +7 more
core   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

Acta Neuropathologica Communications, 2017
Genetic variation in a major histocompatibility complex II (MHCII)-encoding gene (HLA-DR) increases risk for Parkinson disease (PD), and the accumulation of MHCII-expressing immune cells in the brain correlates with α-synuclein inclusions.
Ashley S. Harms, Vedad Delic, Aaron D. Thome, Nicole Bryant, Zhiyong Liu, Sidhanth Chandra, Asta Jurkuvenaite, Andrew B. West   +7 more
doaj   +1 more source

Neuroimaging and Neurodegeneration

Neurodegenerative Diseases, 2023
Botta, Daniele, Lövblad, Karl-Olof
openaire   +3 more sources

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Living alone with dementia is a neglected source of inequality: findings from a scoping review of research evidence

Systematic Reviews
Background With growing proportions of single-person households, increasing numbers of people with dementia are living alone, challenging the still-prevalent assumption that people have an informal carer available.
Linda Clare, Anthony Martyr, Maria Caulfield, Laura D. Gamble, Catherine Charlwood, Jane Ward, Claire Hulme, Matthew Prina, Jan R. Oyebode   +8 more
doaj   +1 more source

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

, 2009
The role of microglial cells in the pathogenesis of Alzheimer’s disease (AD) neurodegeneration is unknown. Although several works suggest that chronic neuroinflammation caused by activated microglia contributes to neurofibrillary degeneration, anti ...
Streit, Wolfgang J., Xue, Qing-Shan, Ingo Bechmann, Bechmann, Ingo, Braak, Heiko, Wolfgang J. Streit, Heiko Braak, Qing-Shan Xue   +7 more
core   +1 more source